2025

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Pflanzenzellen, die mit einem Fluoreszenzmikroskop aufgenommen und mit dem Modell automatisch segmentiert wurden. Die zugrunde liegenden Daten sind dreidimensional und das Bild zeigt eine Darstellung der segmentierten Zellen, die jeweils durch eine andere Farbe repräsentiert werden. Foto: Nature Methods: s41592-021-01249-6

20.02.2025

Automatische Zellanalyse mithilfe von künstlicher Intelligenz

Internationales Forschungsteam entwickelt benutzerfreundliche Software   Um die komplexen Prozesse des Lebens zu verstehen, ist es entscheidend, einzelne Strukturen in Zellen zu erkennen und voneinander zu unterscheiden. Dieser Schritt wird als „Segmentierung“ bezeichnet und ermöglicht es zum Beispiel, die Reaktion von Zellen auf Medikamente zu analysieren. Ein internationales Forschungsteam unter
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20.02.2025

Direct mechanical communication of cellular to nuclear shape in oocytes

Authors Vos BE, Vadapalli Y, Muenker TM, Jentoft IMA, Todisco E, Eskandari MA, Schuh M, Lenart P, Betz T Journal BioRxiv Citation bioRxiv 2025.02.17.638579. Abstract The mechanical properties of the cytoplasm and nucleoplasm are crucial for the correct and robust functioning of a cell and play a key role in
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16.02.2025

Endogenous SNAP-tagging of Munc13-1 for monitoring synapse nanoarchitecture

Authors Kowald M, Bachollet SPJT, Benseler F, Steinecker M, Boll M, Kaushik S, Soykan T, Sun S, Birke R, Ilic D, Brose N, Hörnberg H, Lehmann M, Rizzoli SO, Broichhagen J, Lipstein N Journal BioRxiv Citation bioRxiv 2024.10.08.617143. Abstract Synaptic function is governed by highly regulated protein machineries, whose abundance
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14.02.2025

Molecular Level Super-Resolution Fluorescence Imaging

Authors Radmacher N, Chizhik AI, Nevskyi O, Gallea JI, Gregor I, Enderlein J Journal Annual Review of Biophysics Citation Annu Rev Biophys. 2025 Feb 14. Abstract Over the last 30 years, fluorescence microscopy, renowned for its sensitivity and specificity, has undergone a revolution in resolving ever-smaller details. This advancement began
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13.02.2025

A novel alpha-synuclein K58N missense variant in a patient with Parkinson’s disease

Authors Al-Azzani M, Weber S, Ramalingam N, Ramón M, Shvachiy L, Mestre G, Zech M, Sicking K, Ibáñez de Opakua A, Jayanthi V, Amaral L, Agarwal A, Chandran A, Chaves SR, Winkelmann J, Trenkwalder C, Schwager M, Pauli S, Dettmer U, Fernández CO, Lautenschläger J, Zweckstetter M, Fernandez Busnadiego R,
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13.02.2025

Neuromodulation of the endbulb of Held synapse in the cochlear nucleus

Authors Groshkova MB, Alvanos T, Qi Y, Wang F, Wichmann C, Hua Y, Moser T Journal BioRxiv Citation bioRxiv 2025.02.12.637882. Abstract Synapses vary greatly in synaptic strength and plasticity, even within the same circuitry or set of pre- and postsynaptic neurons. Neuromodulation is a candidate mechanism to explain some of
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12.02.2025

Probing the role of synaptic adhesion molecule RTN4RL2 in setting up cochlear connectivity

Authors Karagulyan N, Überegger M, Qi Y, Babai N, Hofer F, Johnson Chacko L, Wang F, Luque M, Glueckert R, Schrott-Fischer A, Hua Y, Moser T, Bandtlow C Journal eLife Citation eLife14:RP103481. Abstract Sound encoding depends on the precise and reliable neurotransmission at the afferent synapses between the sensory inner
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12.02.2025

Segment Anything for Microscopy

Authors Archit A, Freckmann L, Nair S, Khalid N, Hilt P, Rajashekar V, Freitag M, Teuber C, Buckley G, von Haaren S, Gupta S, Dengel A, Ahmed S, Pape C Journal Nature Methods Citation Nat Methods. 2025 Feb 12. Abstract Accurate segmentation of objects in microscopy images remains a bottleneck
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11.02.2025

Protein misfolding: understanding biology to classify and treat synucleinopathies

Authors Outeiro TF, Höglinger G, Lang AE, Vieira TCRG Journal Journal of Neural Transmission Citation J Neural Transm (Vienna). 2025 Feb 11. Abstract Protein misfolding and aggregation is a major pathological hallmark in a variety of human conditions, including cancer, diabetes, and neurodegeneration. However, we still do not fully understand
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10.02.2025

Substituent Effects in Acetylated Phenyl Azopyrazole Photoswitches

Authors Tovtik R, Marzin D, Weigel P, Crespi S, Simeth NA Journal Beilstein Archives Citation Beilstein Arch. 2025, 20257. Abstract Phenyl azopyrazole photoswitches proved to be valuable structural motifs for various applications ranging from materials science to medicine. Despite their potential, their structural diversity is still limited and a larger
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