2025

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01.10.2025

3D histology of human heart-forming organoids by X-ray phase-contrast tomography

Authors Komorowski K, Reichmann J, Drakhlis L, Zweigerdt R, Salditt T Journal Communications Biology Citation Commun Biol. 2025 Oct 1;8(1):1411. Abstract Three-dimensional (3D) imaging is crucial for elucidating the complex structure of organoid models which involve complex spatial cellular and tissue organization in 3D. While a variety of volume imaging
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01.10.2025

3D imaging of neuronal inclusions and protein aggregates in human neurodegeneration by multiscale X-ray phase-contrast tomography

Authors Franz J, Reichmann J, Eckermann M, Würfel T, Groh A, Qadri SF, Schulz K, Mollenhauer B, Stadelmann C, Salditt T   Journal Brain Pathology   Citation Brain Pathol. 2025 Oct 1:e70044.   Abstract This study leverages x-ray phase-contrast tomography (XPCT) for detailed analysis of neurodegenerative diseases, focusing on the
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30.09.2025

Pharmacological inhibition of V-ATPase targets mode-switching but not the proton transport cycle

Authors Kosmidis E, Fokaeos M, Shuttle CG, Isselstein MC, Cvjetkovic A, Johnson PJ, Pederesen JL, Jahn R, Preobraschenski J, Stamou D Journal BioRxiv Citation bioRxiv 2025.09.28.679038. Abstract Vacuolar-type adenosine triphosphatases (V-ATPases) are rotary proton pumps that establish proton gradients across cellular membranes. Their pharmacological inhibition is currently under active investigation
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26.09.2025

A novel alpha-synuclein G14R missense variant is associated with atypical neuropathological features

Authors Brücke C, Al-Azzani M, Ramalingam N, Ramón M, Sousa RL, Buratti F, Zech M, Sicking K, Amaral L, Gelpi E, Chandran A, Agarwal A, Chaves SR, Fernández CO, Dettmer U, Lautenschläger J, Zweckstetter M, Busnadiego RF, Zimprich A, Outeiro TF Journal Molecular Neurodegeneration Citation Mol Neurodegener. 2025 Sep 26;20(1):98.
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Dr. Dr. Stefan Kallenberger, BioQuant-Zentrum der Universität Heidelberg, Dr. Judith Gronwald, Klinik für Kardiologie und Pneumologie der UMG, und Dr. Funsho E. Fakuade, Institut für Pharmakologie und Toxikologie der UMG, und Prof. Dr. Niels Voigt, Institut für Pharmakologie und Toxikologie der UMG (v.l.n.r.). Foto: umg/eva meyer-besting

23.09.2025

Kalzium verbessert die Vorhersage gefährlicher Herzrhythmusstörungen nach Herzoperation

Forschende der Universitätsmedizin Göttingen (UMG) und des Universitätsklinikums Heidelberg (UKHD) haben gemeinsam unter der Leitung von MBExC Mitglied Prof. Dr. Niels Voigt, Professor für Molekulare Pharmakologie am Institut für Pharmakologie und Toxikologie der UMG, und Dr. Dr. Stefan Kallenberger, Leiter der Arbeitsgruppe für Systemmedizin am BioQuant-Zentrum der Universität Heidelberg, einen
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19.09.2025

High throughput automated patch-clamp of cardiac ion channels using physiological fluoride-free internal solution

Authors Rapedius M, Obergrussberger A, Scholz S, Rinke-Weiss I, Goetze TA, Brinkwirth N, Rotordam MG, Strassmaier T, Randolph A, Friis S, Yang K, Rathje J, Liutkute A, Seibertz F, Voigt N, Fertig N, Stoelzle-Feix S Journal Journal of Pharmacological and Toxicological Methods Citation J Pharmacol Toxicol Methods. 2025. 135, 107825.
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17.09.2025

Optimal Transport Based Testing in Factorial Design

Authors Groppe M, Niemöller L, Hundrieser S, Ventzke D, Blob A, Köster S, Munk A Journal Arxiv Citation arXiv:2509.13970. Abstract We introduce a general framework for testing statistical hypotheses for probability measures supported on finite spaces, which is based on optimal transport (OT). These tests are inspired by the analysis
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17.09.2025

Charting the nanotopography of inner hair cell synapses using MINFLUX nanoscopy

Authors Kapoor R, Kim H, Garlick E, Lima MARBF, Ruhwedel T, Moebius W, Wolf F, Moser T Journal Science Advances Citation Science Advances. 2025. accepted manuscript. Abstract For us to hear, the cochlea encodes sounds into neural signals at synapses of inner hair cells (IHCs) and the auditory nerve with
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Prof. Dr. Melina Schuh © Irene Böttcher-Gajewski / Max-Planck-Institut für Multidisziplinäre Naturwissenschaften.

16.09.2025

Melina Schuh mit Science Breakthrough 2025 geehrt

MBExC Mitglied Melina Schuh, Direktorin am Max-Planck-Institut (MPI) für Multidisziplinäre Naturwissenschaften machte mit ihrem Team erstmals den gesamten Prozess des Eisprungs in Follikeln einer Maus in Echtzeit sichtbar. Für diesen entscheidenden Durchbruch auf ihrem Gebiet wird sie mit dem Science Breakthrough of the Year 2025 in der Kategorie Life Sciences
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15.09.2025

Manipulating mitochondrial gene expression

Authors Dahal D, Cruz-Zargoza LD, Rehling P Journal Biological Chemistry Citation Biol Chem. 2025 Sep 15. Abstract Mitochondria are essential for cellular metabolism, serving as the primary source of adenosine triphosphate (ATP). This energy is generated by the oxidative phosphorylation (OXPHOS) system located in the inner mitochondrial membrane. Impairments in
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