2024

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03.04.2024

Structural basis of Integrator-dependent RNA polymerase II termination

Authors Fianu I, Ochmann M, Walshe JL, Dybkov O, Cruz JN, Urlaub H, Cramer P   Journal Nature   Citation Nature. 2024 Apr 3.   Abstract The Integrator complex can terminate RNA polymerase II (Pol II) in the promoter-proximal region of genes. Previous work has shed light on how Integrator
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03.04.2024

Complexin has a dual synaptic function as checkpoint protein in vesicle priming and as a promoter of vesicle fusion

Authors López-Murcia FJ, Lin KH, Berns MMM, Ranjan M, Lipstein N, Neher E, Brose N, Reim K, Taschenberger H   Journal Proceedings of the National Academy of Sciences of the United States of America   Citation Proc Natl Acad Sci U S A. 2024 Apr 9;121(15):e2320505121.   Abstract The presynaptic
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MBExC Sonderausstellung "Herz & Hirn - gemeinsam verstehen" im Forum Wissen

01.04.2024

Herz und Hirn – gemeinsam verstehen

Neue Sonderausstellung im Forum Wissen beginnt am 18. April 2024   Wie funktioniert ein „Pflaster“ für das Herz? Wie kann man mit Hilfe von Licht hören? Und wie verläuft der Weg von der Grundlagenforschung zur Diagnose und zur Therapie? Diesen Fragen geht die Ausstellung „Herz & Hirn – gemeinsam verstehen“
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29.03.2024

Generation of a pluripotent stem cell line (UMGi270-A) and a corresponding CRISPR/Cas9 modified isogenic control (UMGi270-A-1) from a patient with sudden onset dilated cardiomyopathy harboring a FLNC p.R2187P mutation

Authors Maurer W, Rebs S, Köhne S, Eberl H, Wollnik B, Zibat A, Streckfuss-Bömeke K Journal Stem Cell Research Citation Stem Cell Res. 2024 Mar 29;77:103409. Abstract Filamin C (FLNC) is a highly important actin crosslinker and multi-adaptor protein in striated skeletal and cardiac muscle. Mutations have been linked to
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29.03.2024

Label-free quantification of imaging features in the extracellular matrix of left and right-sided colon cancer tissues

Authors Arora B, Kulkarni A, Markus MA, Ströbel P, Bohnenberger H, Alves F, Ramos-Gomes F Journal Scientific Reports Citation Sci Rep. 2024 Mar 29;14(1):7510. Abstract The molecular pathogenesis of colorectal cancer is known to differ between the right and left side of the colon. Several previous studies have focussed on
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27.03.2024

Dynamic Gain Decomposition Reveals Functional Effects of Dendrites, Ion Channels, and Input Statistics in Population Coding

Authors Zhang C, Revah O, Wolf F, Neef A Journal Journal of Neuroscience Citation J Neurosci. 2024 Mar 27;44(13):e0799232023. Abstract Modern, high-density neuronal recordings reveal at ever higher precision how information is represented by neural populations. Still, we lack the tools to understand these processes bottom-up, emerging from the biophysical
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27.03.2024

Chemical synthesis of site-selective advanced glycation end products in α-synuclein and its fragments

Authors Bosbach C, Gatzemeier LM, Bloch von Blottnitz KI, König A, Diederichsen U, Steinem C, Outeiro TF Journal Organic & Biomolecular Chemistry Citation Org Biomol Chem. 2024 Mar 27;22(13):2670-2676. Abstract Advanced glycation end products (AGEs) arise from the Maillard reaction between dicarbonyls and proteins, nucleic acids, or specific lipids. Notably,
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27.03.2024

Formation of memory assemblies through the DNA-sensing TLR9 pathway

Authors Jovasevic V, Wood EM, Cicvaric A, Zhang H, Petrovic Z, Carboncino A, Parker KK, Bassett TE, Moltesen M, Yamawaki N, Login H, Kalucka J, Sananbenesi F, Zhang X, Fischer A, Radulovic J   Journal Nature   Citation Nature. 2024 Apr;628(8006):145-153.   Abstract As hippocampal neurons respond to diverse types
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25.03.2024

Regulation of Zbp1 by miR-99b-5p in microglia controls the development of schizophrenia-like symptoms in mice

Authors Kaurani L, Islam MR, Heilbronner U, Krüger DM, Zhou J, Methi A, Strauss J, Pradhan R, Schröder S, Burkhardt S, Schuetz AL, Pena T, Erlebach L, Bühler A, Budde M, Senner F, Kohshour MO, Schulte EC, Schmauß M, Reininghaus EZ, Juckel G, Kronenberg-Versteeg D, Delalle I, Odoardi F, Flügel
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25.03.2024

Gene therapy for deafness: are we there now?

Authors Moser T, Chen H, Kusch K, Behr R, Vona B   Journal EMBO Molecular Medicine   Citation EMBO Mol Med. 2024 Mar 25.   Abstract No abstract available.   DOI 10.1038/s44321-024-00058-6   Pubmed Link
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