2023 – Seite 17

19.04.2023

Signatures of heterogeneity in the statistical structure of target state aligned ensembles

Authors Lenner N, Häring M, Eule S, Großhans J, Wolf F Journal ArXiv Citation arXiv:2304.09719. Abstract Finite time convergence to functionally important target states is a key component of many biological processes. We previously found that the terminal approach phase of such dynamics exhibits universal types of stochastic dynamics that

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14.04.2023

IDH3γ functions as a redox switch regulating mitochondrial energy metabolism and contractility in the heart

Authors Nanadikar MS, Vergel Leon AM, Guo J, van Belle GJ, Jatho A, Philip ES, Brandner AF, Böckmann RA, Shi R, Zieseniss A, Siemssen CM, Dettmer K, Brodesser S, Schmidtendorf M, Lee J, Wu H, Furdui CM, Brandenburg S, Burgoyne JR, Bogeski I, Riemer J, Chowdhury A, Rehling P, Bruegmann

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13.04.2023

A Bright Surprise: Live-Cell Labeling with Negatively Charged Fluorescent Probes based on Disulfonated Rhodamines and HaloTag

Authors Kim D, Stoldt S, Weber M, Jakobs S, Belov VN, Hell SW Journal Chemistry Methods Citation Chem. Methods 2023, e202200076. Abstract Disulfonated rhodamines are photostable and bright dyes widely used in life science and optical microscopy. However, di-sulfonated dyes were considered cell impermeable and not applicable

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13.04.2023

3d virtual histology reveals pathological alterations of cerebellar granule cells in multiple sclerosis

Authors Frost J, Schmitzer B, Töpperwien M, Eckermann M, Franz J, Stadelmann C, Salditt T Journal Neuroscience Citation Neuroscience. 2023 Apr 13:S0306-4522(23)00161-6. Abstract We investigate structural properties of neurons in the granular layer of human cerebellum with respect to their involvement in multiple sclerosis (MS). To this end we analyze

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12.04.2023

Andreas Janshoff und Martin Göpfert erhalten Förderung des Human Frontier Science Programms

Göttinger Wissenschaftler sind an HFSP-geförderten Forschungsprojekten beteiligt. Der Biophysiker und MBExC Mitglied Prof. Dr. Andreas Janshoff von der Fakultät für Chemie wird gemeinsam mit Forschenden der University of Warwick (Projektleitung), der Hebrew University of Jerusalem und der Columbia University den Ruhezustand und das Erwachen von Sporen bakteriellen und pilzlichen

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12.04.2023

Monitoring the response to Nintedanib treatment in a mouse model of lung fibrosis using longitudinal X-ray based lung function measurement

Authors Khan A, Markus AM, Svetlove A, Hülsmann S, Alves F, Dullin C Journal Research Square Citation Research Square, 12 April 2023, preprint. Abstract Background: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive, incurable, and debilitating fibrotic disease. Nintedanib – an oral tyrosine kinase inhibitor – significantly slows the IPF

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11.04.2023

Roadmap for Optical Tweezers

Authors Volpe G, Maragò OM, Rubinzstein-Dunlop H, Pesce G, Stilgoe AB, Volpe G, Tkachenko G, Truong VG, Chormaic SN, Kalantarifard F, Elahi P, Käll M, Callegari A, Marqués MI, Neves AAR, Moreira WL, Fontes A, Cesar CL, Saija R, Saidi A, Beck P, Eismann JS, Banzer P, Fernandes TFD, Pedaci

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11.04.2023

Fully-primed slowly-recovering vesicles mediate presynaptic LTP at neocortical neurons

Authors Weichard I, Taschenberger H, Gsell F, Bornschein G, Ritzau-Jost A, Schmidt H, Kittel RJ, Eilers J, Neher E, Hallermann S, Nerlich J Journal BioRxiv Citation bioRxiv 2023.04.11.535831. Abstract Pre- and postsynaptic forms of long-term potentiation (LTP) are candidate synaptic mechanisms underlying learning and memory. At layer

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09.04.2023

Reverse-time analysis and boundary classification of directional biological dynamics with multiplicative noise

Authors Lenner N, Häring M, Eule S, Großhans J, Wolf F Journal ArXiv Citation arXiv:2304.04279. Abstract The dynamics of living systems often serves the purpose of reaching functionally important target states. We previously proposed a theory to analyze stochastic biological dynamics evolving towards target states in reverse

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08.04.2023

Anle138b interaction in α-synuclein aggregates by dynamic nuclear polarization NMR

Authors Dervişoğlu R, Antonschmidt L, Nimerovsky E, Sant V, Kim M, Ryazanov S, Leonov A, Carlos Fuentes-Monteverde J, Wegstroth M, Giller K, Mathies G, Giese A, Becker S, Griesinger C, Andreas LB Journal Methods Citation Methods. 2023 Apr 8:S1046-2023(23)00056-7. Abstract Small molecules that bind to oligomeric protein species such as

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