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06.02.2023

Neuronal extracellular vesicles and associated microRNAs induce circuit connectivity downstream BDNF

Authors Antoniou A, Auderset L, Kaurani L, Sebastian E, Zeng Y, Allahham M, Cases-Cunillera S, Schoch S, Gruendemann J, Fischer A, Schneider A   Journal Cell Reports   Citation Cell Rep. 2023 Feb 6;42(2):112063.   Abstract Extracellular vesicles (EVs) have emerged as mediators of cellular communication, in part via the
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02.02.2023

Actin-driven chromosome clustering facilitates fast and complete chromosome capture in mammalian oocytes

Authors Harasimov K, Uraji J, Mönnich EU, Holubcová Z, Elder K, Blayney M, Schuh M Journal Nature Cell Biology Citation Nat Cell Biol. 2023 Feb 2. Abstract Accurate chromosome segregation during meiosis is crucial for reproduction. Human and porcine oocytes transiently cluster their chromosomes before the onset of spindle assembly
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02.02.2023

The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system

Authors Saha I, Yuste-Checa P, Da Silva Padilha M, Guo Q, Körner R, Holthusen H, Trinkaus VA, Dudanova I, Fernández-Busnadiego R, Baumeister W, Sanders DW, Gautam S, Diamond MI, Hartl FU, Hipp MS Journal Nature Communications Citation Nat Commun. 2023 Feb 2;14(1):560. Abstract Amyloid-like aggregates of the microtubule-associated protein Tau
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01.02.2023

miR-101a-3p Impairs Synaptic Plasticity and Contributes to Synucleinopathy

Authors Xylaki M, Paiva I, Al-Azzani M, Gerhardt E, Jain G, Islam MR, Vasili E, Wassouf Z, Schulze-Hentrich JM, Fischer A, Outeiro TF Journal Journal of Parkinson’s Disease Citation J Parkinsons Dis. 2023 Feb 1. Abstract Background: Synucleinopathies are disorders characterized by the abnormal accumulation of α-synuclein (aSyn). Synaptic compromise
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