01.09.2022
Authors Ostersehlt LM, Jans DC, Wittek A, Keller-Findeisen J, Inamdar K, Sahl SJ, Hell SW, Jakobs S Journal Nature Methods Citation Nat Methods (2022). Abstract MINimal fluorescence photon FLUXes (MINFLUX) nanoscopy, providing photon-efficient fluorophore localizations, has brought about three-dimensional resolution at nanometer scales. However, by using an intrinsic on–off switching
01.09.2022
Neue „Sinneswelten“ Ausstellung 2022
Neue faszinierende Bilder der zweiten “Sinneswelten” Ausstellung wurden von Ende Juni bis Ende August 2022 im Haupteingangsbereich des Universitätsklinikums Göttingen gezeigt. Hier ist ein Video der Ausstellungsbilder zu sehen: Dieses Video auf YouTube ansehen Die Ausstellung bietet bereits zum zweiten Mal wunderbare Einblicke in die Welt der Sinne auf der
01.09.2022
From guide to guard-activation mechanism of the stress-sensing chaperone Get3
Authors Ulrich K, Farkas Á, Chan O, Katamanin O, Schwappach B, Jakob U Journal Molecular Cell Citation Mol Cell. 2022 Sep 1;82(17):3226-3238.e7. Abstract Oxidative stress conditions can cause ATP depletion, oxidative protein unfolding, and potentially toxic protein aggregation. To alleviate this proteotoxic stress, the highly conserved yeast protein, Get3, switches
01.09.2022
Structure of angiogenin dimer bound to double-stranded RNA
Authors Sievers K, Ficner R Journal Acta Crystallographica Section F-Structural Biology Communications Citation Acta Crystallogr F Struct Biol Commun. 2022 Sep 1;78(Pt 9):330-337. Abstract Angiogenin is an unusual member of the RNase A family and is of great interest in multiple pathological contexts. Although it has been assigned various regulatory
26.08.2022
Multiscale architecture: Mechanics of composite cytoskeletal networks
Authors Lorenz C, Köster S Journal Biophysics Reviews Citation Biophysics Rev. 3, 031304 (2022) Abstract Different types of biological cells respond differently to mechanical stresses, and these responses are mainly governed by the cytoskeleton. The main components of this biopolymer network are actin filaments, microtubules, and intermediate filaments, whose mechanical
25.08.2022
Combined optical fluorescence microscopy and X-ray tomography reveals substructures in cell nuclei in 3D
Authors Wittmeier A, Bernhardt M, Robisch A-L, Cassini C, Osterhoff M, Salditt T, Köster S Journal Biomedical Optics Express Citation Biomed. Opt. Express 13, 4954-4969 (2022) Abstract The function of a biological cell is fundamentally defined by the structural architecture of packaged DNA in the nucleus. Elucidating information about the
23.08.2022
JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species
Authors Santos CC, Cardim-Pires TR, Shvachiy L, Fonseca-Fonseca LA, Muñoz P, Almeida ÁMAN, Costa ACS, Teles-Souza J, Ochoa-Rodríguez E, de Fátima Dias Costa M, Palhano FL, Segura-Aguilar J, Barbosa DB, do Bomfim MR, Dos Santos Junior MC, Leite FHA, da Rocha Pita SS, Costa SL, Núñez-Figueredo Y, Outeiro TF, Foguel
22.08.2022
There is no F in APC: Using physiological fluoride-free solutions for high throughput automated patch clamp experiments
Authors Rapedius M, Obergrussberger A, Humphries ESA, Scholz S, Rinke-Weiss I, Goetze TA, Brinkwirth N, Rotordam MG, Strassmaier T, Randolph A, Friis S, Liutkute A, Seibertz F, Voigt N, Fertig N Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci., 22 August 2022. Abstract Fluoride has been used in the
18.08.2022
A review of protocols for human iPSC culture, cardiac differentiation, subtype-specification, maturation, and direct reprogramming
Authors Lyra-Leite DM, Gutiérrez-Gutiérrez Ó, Wang M, Zhou Y, Cyganek L, Burridge PW Journal Star Protocols Citation STAR Protoc. 2022 Aug 18;3(3):101560. Abstract The methods for the culture and cardiomyocyte differentiation of human embryonic stem cells, and later human induced pluripotent stem cells (hiPSC), have moved from a complex and
18.08.2022
„Sinneswelten“ Ausstellung an der UMG
Die faszinierenden Bilder der diesjährigen Ausstellung „Sinneswelten“ sind noch bis zum 25. August 2022 im Haupteingangsbereich des Universitätsklinikums Göttingen zu sehen. Die Ausstellung bietet wunderbare Einblicke in die Welt der Sinne auf der zellulären Ebene der Sinneszellen und Neuronen aus einer künstlerischen Perspektive. Die gezeigten Bilder sind Ergebnisse der täglichen