2022

02.06.2022

Resolving the molecular architecture of the photoreceptor active zone by 3D-MINFLUX

Authors Grabner CP, Jansen I, Neef J, Weihs T, Schmidt R, Riedel D, Wurm CA, Moser T Journal Science Advances Citation Sci Adv. 2022 Jul 15;8(28):eabl7560. Abstract Cells assemble macromolecular complexes into scaffoldings that serve as substrates for catalytic processes. Years of molecular neurobiology indicate that neurotransmission depends on such

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01.06.2022

Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, double-blind, placebo-controlled phase 1a trial

Authors Levin J, Sing N, Melbourne S, Morgan A, Mariner C, Spillantini MG, Wegrzynowicz M, Dalley JW, Langer S, Ryazanov S, Leonov A, Griesinger C, Schmidt F, Weckbecker D, Prager K, Matthias T, Giese A Journal eBioMedicine Citation EBioMedicine. 2022 Jun;80:104021 Abstract Background: Synucleinopathies such as Parkinson ́ s disease

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01.06.2022

Statistical Methods for Minimax Estimation in Linear Models with Unknown Design Over Finite Alphabets

Authors Behr M, Munk A Journal SIAM Journal on Mathematics of Data Science Citation SIAM Journal on Mathematics of Data Science 4(2):490-513. Abstract We provide a minimax optimal estimation procedure for F and W in matrix valued linear models Y = F W + Z where the parameter matrix W

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31.05.2022

A fluorescent nanosensor paint detects dopamine release at axonal varicosities with high spatiotemporal resolution

Authors Elizarova S, Chouaib A, Shaib A, Hill B, Mann F, Brose N, Kruss S, Daniel JA Journal PNAS Citation Proc Natl Acad Sci U S A. 2022 May 31;119(22):e2202842119. Abstract The neurotransmitter dopamine controls normal behavior and dopaminergic dysfunction is prevalent in multiple brain diseases. To reach a detailed

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31.05.2022

Tiago Outeiro und Annekatrin König erhalten Innovationspreis der Parkinson-Stiftung

Die „Parkinson-Stiftung“ zeichnet Wissenschaftler*innen der Universitätsmedizin Göttingen für ihren Projektvorschlag „Glykierung von alpha-Synuclein als Biomarker“ mit dem Innovations-Preis in der Kategorie „Grundlagenforschung“ aus. Innovations-Preis ist mit 100.000 Euro dotiert. Dr. Annekatrin König, wissenschaftliche Mitarbeiterin, und Prof. Dr. Tiago Fleming Outeiro, MBExC-Mitglied und Direktor der Abteilung für Experimentelle Neurodegeneration der Universitätsmedizin

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27.05.2022

Oct4 differentially regulates chromatin opening and enhancer transcription in pluripotent stem cells

Authors Xiong L, Tolen EA, Choi J, Velychko S, Caizzi L, Velychko T, Adachi K, MacCarthy CM, Lidschreiber M, Cramer P, Schoeler HR Journal eLife Citation eLife 11:e71533. Abstract The transcription factor Oct4 is essential for the maintenance and induction of stem cell pluripotency, but its functional roles are not

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27.05.2022

Dopamin-Nanosensoren messen Signalübertragung zwischen Nervenzellen

Göttinger Forschenden ist es gelungen, die Freisetzung des Botenstoffs Dopamin aus Nervenzellen mit bislang unerreichter Genauigkeit zu messen. Dies ermöglicht, die Mechanismen der Dopamin-Signalübertragung detaillierter zu untersuchen und so aufzuklären, wie damit zusammehängende Krankheiten entstehen. Link zur MPI-NAT Pressemitteilung

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27.05.2022

Remote control of the heart and beyond

Authors Zimmermann WH Journal Science Citation Science. 2022 May 27;376(6596):917-918. Abstract A resorbable closed-loop sensor-actuator implant can temporarily control heart rate. DOI 10.1126/science.abq0605 Pubmed Link

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26.05.2022

Excited state lifetime modulation in semiconductor nanocrystals for super-resolution imaging

Authors Ghosh S, Hollingsworth JA, Gallea JI, Majumder S, Enderlein J, Chizhik AI Journal Nanotechnology Citation Nanotechnology. 2022 Jun 15;33(36). Abstract We report on proof of principle measurements of a concept for a super-resolution imaging method that is based on excitation field density-dependent lifetime modulation of semiconductor nanocrystals. The prerequisite

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25.05.2022

Electrically Controlling and Optically Observing the Membrane Potential of Supported Lipid Bilayers

Authors Yudovich S, Marzouqe A, Kantorovitsch J, Teblum E, Chen T, Enderlein J, Miller EW, Weiss S Journal Biophysical Journal Citation Biophys J. 2022 May 25:S0006-3495(22)00430-1 Abstract Supported lipid bilayers are a well-developed model system for the study of membranes and their associated proteins, such as membrane channels, enzymes, and

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