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A bovine egg after fertilization: The parental genomes are still located in two separate pronuclei. Before unification, the chromosomes (magenta) cluster at the pronuclear interface. Part of the cytoskeleton is colored blue. Super resolution microscopy image. © Tommaso Cavazza and Melina Schuh / Max Planck Institute for Biophysical Chemistry

07.05.2021

Fehler am Anfang des Lebens

Mütterliches und väterliches Erbgut vereinigen sich in einem erstaunlich störungsanfälligen Prozess Statistisch führt bei Frauen nur jede dritte Befruchtung zu einer erfolgreichen Schwangerschaft. Viele Embryonen überstehen die frühe Entwicklungsphase nicht. Zellbiologinnen und -biologen am Göttinger Max-Planck-Institut (MPI) für biophysikalische Chemie haben nun gemeinsam mit Forschenden am Friedrich-Loeffler-Institut, Institut für Nutztiergenetik
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07.05.2021

Parental genome unification is highly erroneous in mammalian embryos

Authors Cavazza T, Takeda Y, Politi AZ, Aushev M, Aldag P, Baker C, Choudhary M, Bucevičius J, Lukinavičius G, Elder K, Blayney M, Lucas-Hahn A, Niemann H, Herbert M, Schuh M Journal Cell Citation Cell. 2021 Apr 30:S0092-8674(21)00492-X. Abstract Most human embryos are aneuploid. Aneuploidy frequently arises during the early
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07.05.2021

Rapid multi-plane phase-contrast microscopy reveals torsional dynamics in flagellar motion

Authors Mojiri S, Isbaner S, Mühle S, Jang H, Bae AJ, Gregor I, Golami A, Enderlein J Journal Biomedical Optics Express Citation Biomed. Opt. Express 12, 3169-3180 (2021). Abstract High speed volumetric optical microscopy is an important tool for observing rapid processes in living cells or for real-time tracking of
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07.05.2021

Utility of red-light ultrafast optogenetic stimulation of the auditory pathway

Authors Bali B, Lopez de la Morena D, Mittring A, Mager T, Rankovic V, Huet AT, Moser T Journal EMBO Molecular Medicine Citation EMBO Mol Med. 2021 May 7:e13391. Abstract Optogenetic stimulation of spiral ganglion neurons (SGNs) in the ear provides a future alternative to electrical stimulation used in current
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06.05.2021

Efficient RNA polymerase II pause release requires U2 snRNP function

Authors Caizzi L, Monteiro-Martins S, Schwalb B, Lysakovskaia K, Schmitzova J, Sawicka A, Chen Y, Lidschreiber M, Cramer P Journal Molecular Cell Citation Mol Cell. 2021 May 6;81(9):1920-1934.e9. Abstract Transcription by RNA polymerase II (Pol II) is coupled to pre-mRNA splicing, but the underlying mechanisms remain poorly understood. Co-transcriptional splicing
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06.05.2021

Tejaas: reverse regression increases power for detecting trans-eQTLs

Authors Banerjee S, Simonetti FL, Detrois KE, Kaphle A, Mitra R, Nagial R, Söding J Journal Genome Biology Citation Genome Biol. 2021 May 6;22(1):142. Abstract Trans-acting expression quantitative trait loci (trans-eQTLs) account for ≥70% expression heritability and could therefore facilitate uncovering mechanisms underlying the origination of complex diseases. Identifying trans-eQTLs
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05.05.2021

Transport Dependency: Optimal Transport Based Dependency Measures

Authors Nies TG, Staudt T, Munk A Journal ArXiv Citation arXiv:2105.02073. Abstract For probability measures supported on countable spaces we derive limit distributions for empirical entropic optimal transport quantities. In particular, we prove that the corresponding plan converges weakly to a centered Gaussian process. Furthermore, its optimal value is shown
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03.05.2021

Dysfunction of RAB39B-Mediated Vesicular Trafficking in Lewy Body Diseases

Authors Koss DJ, Campesan S, Giorgini F, Outeiro TF Journal Movement Disorders Citation Mov Disord. 2021 May 3. Abstract Intracellular vesicular trafficking is essential for neuronal development, function, and homeostasis and serves to process, direct, and sort proteins, lipids, and other cargo throughout the cell. This intricate system of membrane
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