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29.05.2021

LC-MS Based Platform Simplifies Access to Metabolomics for Peroxisomal Disorders

Authors Klemp HG, Kettwig M, Streit F, Gärtner J, Rosewich H, Krätzner R Journal Metabolites Citation Metabolites. 2021 May 29;11(6):347. Abstract Peroxisomes are central hubs for cell metabolism and their dysfunction is linked to devastating human disorders, such as peroxisomal biogenesis disorders and single peroxisomal enzyme/protein deficiencies. For decades, biochemical
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28.05.2021

Ruler elements in chromatin remodelers set nucleosome array spacing and phasing

Authors Oberbeckmann E, Niebauer V, Watanabe S, Farnung L, Moldt M, Schmid A, Cramer P, Peterson CL, Eustermann S, Hopfner KP, Korber P Journal Nature Communications Citation Nat Commun. 2021 May 28;12(1):3232. Abstract Arrays of regularly spaced nucleosomes dominate chromatin and are often phased by alignment to reference sites like
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27.05.2021

Pore-Spanning Plasma Membranes Derived from Giant Plasma Membrane Vesicles

Authors Teiwes NK, Mey I, Baumann PC, Strieker L, Unkelbach U, Steinem C Journal ACS Applied Materials & Interfaces Citation ACS Appl Mater Interfaces. 2021 Jun 9;13(22):25805-25812. Abstract Giant plasma membrane vesicles (GPMVs) are a highly promising model system for the eukaryotic plasma membrane. The unresolved challenge, however, is a
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Synapses in neuronal cell cultures, stained with methods newly developed in CRC 1286 Source: Rizzoli, UMG

25.05.2021

DFG verlängert die Förderung des SFB 1286 “Quantitative Synaptology”

Die Deutsche Forschungsgemeinschaft (DFG) fördert den SFB 1286 „Quantitative Synaptologie“ an der Universitätsmedizin Göttingen auch in den nächsten vier Jahren mit rund zehn Millionen Euro für die Erforschung von Synapsen und die Entwicklung einer computergestützten Synapsen-Simulation. MBExC-Mitglied Silvio Rizzoli ist Sprecher des SFB 1286, Direktor des Instituts für Neuro- und
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21.05.2021

Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2

Authors Fianu I, Dienemann C, Aibara S, Schilbach S, Cramer P Journal Communications Biology Citation Commun Biol. 2021 May 21;4(1):606. Abstract Nuclear import of RNA polymerase II (Pol II) involves the conserved factor RPAP2. Here we report the cryo-electron microscopy (cryo-EM) structure of mammalian Pol II in complex with human
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21.05.2021

Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology

Authors Kargapolova Y, Rehimi R, Kayserili H, Brühl J, Sofiadis K, Zirkel A, Palikyras S, Mizi A, Li Y, Yigit G, Hoischen A, Frank S, Russ N, Trautwein J, van Bon B, Gilissen C, Laugsch M, Gusmao EG, Josipovic N, Altmüller J, Nürnberg P, Längst G, Kaiser FJ, Watrin E,
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13.04.2021, Göttingen: Kyro-Elektronen Mikrosokop. Foto: Swen Pförtner

20.05.2021

Revolutionäre Hochleistungsmikroskopie für das Göttinger Exzellenzcluster MBExC

Die Deutsche Forschungsgemeinschaft und das Land Niedersachsen fördern die Anschaffung eines Instrumentariums für Kryo-Elektronenmikroskopie/-tomographie für Forschende um UMG-Professor Dr. Rubén Fernández-Busnadiego am Exzellenzcluster MBExC. Die Instrumente wurden im April angeliefert und in Räumlichkeiten in der Fakultät für Physik der Universität Göttingen aufgestellt. Beschaffung und Umbau wurden mit insgesamt rund 7,3
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18.05.2021

α-Synuclein in Plasma-Derived Extracellular Vesicles Is a Potential Biomarker of Parkinson’s Disease

Authors Stuendl A, Kraus T, Chatterjee M, Zapke B, Sadowski B, Moebius W, Hobert MA, Deuschle C, Brockmann K, Maetzler W, Mollenhauer B, Schneider A Journal Movement Disorders Citation Mov Disord. 2021 May 18. Abstract Background: Extracellular vesicles are small vesicles that are released from many cells, including neurons. α-Synuclein
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14.05.2021

Insights into the molecular mechanism of amyloid filament formation: Segmental folding of α-synuclein on lipid membranes

Authors Antonschmidt L, Dervişoğlu R, Sant V, Movellan KT, Mey I, Riedel D, Steinem C, Becker S, Andreas LB, Griesinger C Journal Science Advances Citation Sci Adv. 2021 May 14;7(20):eabg2174. Abstract Recent advances in the structural biology of disease-relevant α-synuclein fibrils have revealed a variety of structures, yet little is
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10.05.2021

Physics-based reconstruction methods for magnetic resonance imaging

Authors Wang X, Tan Z, Scholand N, Roeloffs V, Uecker M Journal Philosophical Transactions Series A. Mathematical, physical, and engineering sciences Citation Philos Trans A Math Phys Eng Sci. 2021 Jun 28;379(2200):20200196. Abstract Conventional magnetic resonance imaging (MRI) is hampered by long scan times and only qualitative image contrasts that
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