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Dr. Sebastian Jähne, Postdoctoral researcher at the Institute of Neuro- and Sensory Physiology, UMG, is first author of the Cell Reports publication. Photo: S. Jähne

18.03.2021

Wie Synapsen ihre Aktivität trotz Alterung aufrechterhalten

Wissenschaftler des Göttinger Exzellenzclusters Multiscale Bioimaging (MBExC) und des Sonderforschungsbereichs 1286 der Universitätsmedizin Göttingen und des Max-Planck-Instituts für Dynamik und Selbstorganisation decken einen Zusammenhang zwischen Proteinumsatz und synaptischer Aktivität auf. Veröffentlicht in Cell Reports. Link to the press release
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Legend to the graphic: Newly made proteins incorporate a label consisting of the essential amino acid leucine containing the rare nitrogen isotope 15N. This label allows the detection of newly made proteins in individual synapses by imaging mass spectrometry. The activity of the same synapses was determined with fluorescence microscopy. These combined measurements confirmed the model prediction that synaptic boutons have a demand-dependent supply of synaptic vesicles: more active presynapses have more newly made synaptic proteins. This correlation was disrupted by chronic activation or inhibition of synaptic activity. (Graphic: Cell Reports/ Sebastian Jähne, UMG)

18.03.2021

How synapses maintain their activity despite ageing

Scientists of the Göttingen Cluster of Excellence Multiscale Bioimaging (MBExC) and the Collaborative Research Center 1286, University Medical Center Göttingen and Max Planck Institute for Dynamics and Self-Organization uncover a link between protein turnover and synaptic activity. Published in Cell Reports. (mbexc/umg) Synapses, the communication sites between nerve cells, are
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18.03.2021

Sequence determinants of human gene regulatory elements

Authors Sahu B, Hartonen T, Pihlajamaa P, Wie B, Dave K, Zhu F, Kaasinen E, Lidschreiber K, Lidschreiber M, Daub CO, Cramer P, Kivioja T, Taipale J Journal bioRxiv Citation bioRxiv 2021.03.18.435942. Abstract DNA determines where and when genes are expressed, but the full set of sequence determinants that control
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