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31.03.2021

The structure of Prp2 bound to RNA and ADP-BeF3− reveals structural features important for RNA unwinding by DEAH-box ATPases

Authors Hamann F, Zimmerningkat LC, Becker RA, Garbers TB, Neumann P, Hubc JS, Ficner R Journal Acta Crystallographica Section D-Structural Biology Citation Acta Cryst. (2021). D77, 496-509. Abstract Noncoding intron sequences present in precursor mRNAs need to be removed prior to translation, and they are excised via the spliceosome, a
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Prof. Dr. Patrick Cramer© Irene Bötther-Gajewski / Max-Planck-Institut für biophysikalische Chemie

26.03.2021

Otto-Warburg-Medaille für Patrick Cramer

Die Deutsche Gesellschaft für Biochemie und Molekularbiologie (GBM) ehrt den Göttinger Max-Planck-Direktor und MBExC-Mitglied Patrick Cramer mit der Otto-Warburg-Medaille. Auf der virtuellen Veranstaltung stellte er seine neuesten Ergebnisse aus der Coronaforschung vor. Link zur Pressemitteilung des MPI-BPC
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25.03.2021

Colocalization for super-resolution microscopy via optimal transport

Authors Tameling C, Stoldt S, Stephan T, Naas J, Jakobs S, Munk A Journal Nature Computational Science Citation Nat Comput Sci 1, 199–211 (2021). Abstract Super-resolution fluorescence microscopy is a widely used technique in cell biology. Stimulated emission depletion (STED) microscopy enables the recording of multiple-color images with subdiffraction resolution.
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23.03.2021

Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex

Authors Ulmke PA, Sakib MS, Ditte P, Sokpor G, Kerimoglu C, Pham L, Xie Y, Mao X, Rosenbusch J, Teichmann U, Nguyen HP, Fischer A, Eichele G, Staiger JF, Tuoc T Journal Stem Cell Reports Citation Stem Cell Reports. 2021 Mar 23:S2213-6711(21)00138-7. Abstract Intermediate progenitor cells (IPCs) are neocortical neuronal
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23.03.2021

RIM-binding proteins are required for normal sound-encoding at afferent inner hair cell synapses

Authors Krinner S, Predoehl F, Burfeind D, Vogl C, Moser T Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci. 14:651935. Abstract The afferent synapses between inner hair cells (IHC) and spiral ganglion neurons are specialized to faithfully encode sound with sub-millisecond precision over prolonged periods of time. Here, we
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23.03.2021

Multiscale photonic imaging of the native and implanted cochlea

Authors Keppeler D, Kampshoff C, Thirumalai A, Duque-Afonso CJ, Schaeper J, Quilitz T, Töpperwien M, Vogl C, Hessler R, Meyer A, Salditt T, Moser T Journal PNAS Citation PNAS May 4, 2021 118 (18) e2014472118. Abstract The cochlea of our auditory system is an intricate structure deeply embedded in the
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22.03.2021

Origins and mechanisms leading to aneuploidy in human eggs

Authors Wartosch L, Schindler K, Schuh M, Gruhn JR, Hoffmann ER, McCoy RC, Xing J Journal Prenatal Diagnosis Citation Prenatal Diagnosis. 2021;1–11. Abstract The gain or loss of a chromosome—or aneuploidy—acts as one of the major triggers for infertility and pregnancy loss in humans. These chromosomal abnormalities affect more than
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20.03.2021

RIM-Binding Protein 2 Organizes Ca2+ Channel Topography and Regulates Release Probability and Vesicle Replenishment at a Fast Central Synapse

Authors Butola T, Alvanos T, Hintze A, Koppensteiner P, Kleindienst D, Shigemoto R, Wichmann C, Moser T Journal Journal of Neuroscience Citation J. Neurosci. 2021, 41 (37) 7742-7767 Abstract Rab-interacting molecule (RIM)-binding protein 2 (BP2) is a multidomain protein of the presynaptic active zone (AZ). By binding to RIM, bassoon
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Dr. Sebastian Jähne, Postdoctoral researcher at the Institute of Neuro- and Sensory Physiology, UMG, is first author of the Cell Reports publication. Photo: S. Jähne

18.03.2021

Wie Synapsen ihre Aktivität trotz Alterung aufrechterhalten

Wissenschaftler des Göttinger Exzellenzclusters Multiscale Bioimaging (MBExC) und des Sonderforschungsbereichs 1286 der Universitätsmedizin Göttingen und des Max-Planck-Instituts für Dynamik und Selbstorganisation decken einen Zusammenhang zwischen Proteinumsatz und synaptischer Aktivität auf. Veröffentlicht in Cell Reports. Link to the press release
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Legend to the graphic: Newly made proteins incorporate a label consisting of the essential amino acid leucine containing the rare nitrogen isotope 15N. This label allows the detection of newly made proteins in individual synapses by imaging mass spectrometry. The activity of the same synapses was determined with fluorescence microscopy. These combined measurements confirmed the model prediction that synaptic boutons have a demand-dependent supply of synaptic vesicles: more active presynapses have more newly made synaptic proteins. This correlation was disrupted by chronic activation or inhibition of synaptic activity. (Graphic: Cell Reports/ Sebastian Jähne, UMG)

18.03.2021

How synapses maintain their activity despite ageing

Scientists of the Göttingen Cluster of Excellence Multiscale Bioimaging (MBExC) and the Collaborative Research Center 1286, University Medical Center Göttingen and Max Planck Institute for Dynamics and Self-Organization uncover a link between protein turnover and synaptic activity. Published in Cell Reports. (mbexc/umg) Synapses, the communication sites between nerve cells, are
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