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16.11.2020

From iPS Cells to Rodents and Nonhuman Primates: Filling Gaps in Modeling Parkinson’s Disease

Authors Outeiro TF, Heutink P, Bezard E, Cenci AM Journal Movement Disorders Citation Mov Disord. 2020 Nov 16. Abstract Parkinson’s disease (PD) is primarily known as a movement disorder because of typical clinical manifestations associated with the loss of dopaminergic neurons in the substantia nigra. However, it is now widely
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13.11.2020

Pharmacological Modulators of Tau Aggregation and Spreading

Authors Dominguez-Meijide A, Vasili E, Outeiro TF Journal Brain Science Citation Brain Sci. 2020 Nov 13;10(11):E858. Abstract Tauopathies are neurodegenerative disorders characterized by the deposition of aggregates composed of abnormal tau protein in the brain. Additionally, misfolded forms of tau can propagate from cell to cell and throughout the brain.
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13.11.2020

Variational Multiscale Nonparametric Regression: Algorithms and Implementation

Authors del Alamo M, Li H, Munk A, Werner F Journal Algorithms Citation Algorithms 2020, 13(11), 296. Abstract Many modern statistically efficient methods come with tremendous computational challenges, often leading to large-scale optimisation problems. In this work, we examine such computational issues for recently developed estimation methods in nonparametric regression
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12.11.2020

CG-SENSE revisited: Results from the first ISMRM reproducibility challenge

Authors Maier O, Baete SH, Fyrdahl A, Hammernik K, Harrevelt S, Kasper L, Karakuzu A, Loecher M, Patzig F, Tian Y, Wang K, Gallichan D, Uecker M, Knoll F Journal Magnetic Resonance in Medicine Citation Magn Reson Med. 2020 Nov 12. Abstract Purpose: The aim of this work is to
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12.11.2020

Mini-Symposium „Excitable cell networks in heart and brain“

am 23. und 30. November 2020, jeweils von 13.00 bis 17.00 Uhr über ZOOM Dieses Mini-Symposium konzentriert sich auf die skalenübergreifende Analyse der Informationsverarbeitung in kardialen und/oder neuronalen Netzwerken mit Hilfe von Bildgebung, Optogenetik und/oder Elektrophysiologie sowie computergestützter Modellierung. Eine solche skalenübergreifende Analyse überträgt die Erkenntnisse aus den strukturellen und
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12.11.2020

Extracellular matrix remodeling through endocytosis and resurfacing of Tenascin-R

Authors Dankovich TM, Kaushik R, Olsthoorn LHM, Petersen GC, Giro PE, Kluever V, Agüi-Gonzalez P, Grewe K, Bao G, Beuermann S, Hadi HA, Doeren J, Klöppner S, Cooper BH, Dityatev A, Rizzoli SO Journal Nature Communications Citation Nat Commun. 2021 Dec 8;12(1):7129. Abstract The brain extracellular matrix (ECM) consists of
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09.11.2020

Distinct insulin granule subpopulations implicated in the secretory pathology of diabetes types 1 and 2

Authors Kreutzberger AJB, Kiessling V, Doyle CA, Schenk N, Upchurch CM, Elmer-Dixon M, Ward AE, Preobraschenski J, Hussein SS, Tomaka W, Seelheim P, Kattan I, Harris M, Liang B, Kenworthy AK, Desai BN, Leitinger N, Anantharam A, Castle JD, Tamm LK Journal Elife Citation Elife. 2020 Nov 9;9:e62506. Abstract Insulin
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09.11.2020

X-ray diffraction and second harmonic imaging reveal new insights into structural alterations caused by pressure-overload in murine hearts

Authors Nicolas JD, Khan A, Markus A, Mohamed BA, Toischer K, Alves F, Salditt T Journal Scientific Reports Citation Sci Rep. 2020 Nov 9;10(1):19317. Abstract We demonstrate a label-free imaging approach to study cardiac remodeling of fibrotic and hypertrophic hearts, bridging scales from the whole organ down to the molecular
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Neurons of the cochlear spiral ganglion transmit auditory input to the brainstem for further processing. Here, substructures of the neuronal cytoskeleton were labelled to visualize individual nerve fibers and cell bodies. Source: Cristian Setz, Christian Vogl, Tobias Moser, IAN, UMG, 2018.

09.11.2020

Exhibition „Sinneswelten“ (World of Senses)

Since October 2020, fascinating enlargements of microscope images are presented in the exhibition „Sinneswelten“ (World of Senses) at the University Medical Center Göttingen. The gallery can be visited by patients, students and UMG employees, and is located between the main entrance and the Bettenhaus 1 . Due to the corona
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Neurons of the cochlear spiral ganglion transmit auditory input to the brainstem for further processing. Here, substructures of the neuronal cytoskeleton were labelled to visualize individual nerve fibers and cell bodies. Source: Cristian Setz, Christian Vogl, Tobias Moser, IAN, UMG, 2018.

09.11.2020

Ausstellung „Sinneswelten“

Die Ausstellung „Sinneswelten“ bietet wunderbare Einblicke in die Welt der Sinne auf der zellulären Ebene der Sinneszellen und Neuronen aus einer künstlerischen Perspektive. Die gezeigten Bilder sind Ergebnisse der täglichen Arbeit der Wissenschaftler des Sonderforschungsbereichs 889 (SFB 889). Sie wurden mit verschiedenen mikroskopischen Techniken aufgenommen und offenbaren die Schönheit der
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