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The lab of Dr. Opazo develops new probes from alpaca antibodies (nanobodies) to be used as tools in neurosciences and super-resolution microscopy. The Alpacas Pepe, Atahualpa, James and Castano (l-r), NanoTag Biotechnology GmbH. Photo: Dr. F. Opazo, BIN.

17.07.2020

Neuer Biosensor spürt die Übertragung des Parkinson-assoziierten α-Synuklein Proteins von einer Zelle zur anderen auf

Wissenschaftler des Exzellenzclusters Multiscale Bioimaging entwickeln einen neuen Biosensor, der die Übertragung von menschlichem α-Synuclein, einem Schlüsselprotein der Parkinson-Krankheit, nachweisen kann. Veröffentlicht in Nature Communications. In der kürzlich veröffentlichten Studie beschreiben die Wissenschaftler*innen unter Leitung von Dr. Felipe Opazo (BIN) und Prof. Dr. Silvio O. Rizzoli, Direktor des Instituts für
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The lab of Dr. Opazo develops new probes from alpaca antibodies (nanobodies) to be used as tools in neurosciences and super-resolution microscopy. The Alpacas Pepe, Atahualpa, James and Castano (l-r), NanoTag Biotechnology GmbH. Photo: Dr. F. Opazo, BIN.

17.07.2020

New biosensor detects cell-to-cell transmission of the Parkinson-associated protein α-Synuclein

Scientists of the Cluster of Excellence Multiscale Bioimaging develop a new biosensor capable of detecting the transmission of human α-synuclein, a key protein associated to Parkinson’s disease. Published in Nature Communications. (umg/mbexc) Human alpha-synuclein (hαSyn) is a physiological protein that is primarily found in nerve cells, and is involved in
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Optical cochlear implant in the cochlea of a gerbil

Optical cochlear implant in the cochlea of a gerbil: The Reconstruction of the spiral-shaped cochlea of a gerbil (grey) was generated by X-ray tomography images at the Institute for X-ray Physics (Prof. Dr. Tim Salditt) at the University of Göttingen. The spiral ganglion with the auditory nerve cells is shown in purple. The optical cochlear implant is shown in blue, the μLEDs are visible as blue dots. Source: Prof. Salditt, University of Göttingen

06.07.2020

Lighting array in the ear: First use of multi-channel cochlear implants with microscale light-emitting diodes

A milestone in hearing research: Researchers at the University Medical Center Göttingen and the University of Freiburg combine for the first time gene therapy in the cochlea with optical cochlear implants to optogenetically activate the auditory pathway in gerbils. Published in EMBO Molecular Medicine. (umg/mbexc) Conventional hearing prostheses, so-called cochlear
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06.07.2020

A comparative analysis of the mobility of 45 proteins in the synaptic bouton

Authors Reshetniak S, Ußling JE, Perego E, Rammner B, Schikorski T, Fornasiero EF, Truckenbrodt S, Köster S, Rizzoli S Journal EMBO Journal Citation EMBO J. 2020 Jul 6;e104596. Abstract Many proteins involved in synaptic transmission are well known, and their features, as their abundance or spatial distribution, have been analyzed
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06.07.2020

Intronic CRISPR Repair in a Preclinical Model of Noonan Syndrome-Associated Cardiomyopathy

Authors Hanses U, Kleinsorge M, Roos L, Yigit G, Li Y, Barbarics B, El-Battrawy I, Lan H, Tiburcy M, Hindmarsh R, Lenz C, Salinas G, Diecke S, Müller C, Adham I, Altmüller J, Nürnberg P, Paul T, Zimmermann WH, Hasenfuss G, Wollnik B, Cyganek L Journal Circulation Citation Circulation. 2020;10.1161/CIRCULATIONAHA.119.044794.
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Optical cochlear implant in the cochlea of a gerbil

Optical cochlear implant in the cochlea of a gerbil: The Reconstruction of the spiral-shaped cochlea of a gerbil (grey) was generated by X-ray tomography images at the Institute for X-ray Physics (Prof. Dr. Tim Salditt) at the University of Göttingen. The spiral ganglion with the auditory nerve cells is shown in purple. The optical cochlear implant is shown in blue, the μLEDs are visible as blue dots. Source: Prof. Salditt, University of Göttingen

03.07.2020

Lichtorgel im Ohr: Erstmals Einsatz von vielkanaligen Cochlea-Implantaten mit Mikro-Leuchtdioden

Ein Meilenstein in der Hörforschung: Forscher*innen der Universitätsmedizin Göttingen sowie der Albert-Ludwigs-Universität Freiburg kombinieren erstmals die Gentherapie in der Hörschnecke mit optischen Cochlea-Implantaten, um die Hörbahn von Wüstenrennmäusen optogenetisch zu aktivieren. Da der Hörnerv natürlicherweise nicht auf Licht reagiert, muss er durch gentherapeutische Eingriffe zunächst lichtempfindlich gemacht werden. An einem
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01.07.2020

Molecular signature of slowly expanding lesions in progressive multiple sclerosis

Authors Jäckle K, Zeis T, Schaeren-Wiemers N, Junker A, van der Meer F, Kramann N, Stadelmann C, Brück W Journal Brain Citation Brain. 2020 Jul 1;143(7):2073-2088. Abstract Multiple sclerosis is an immune-mediated chronic inflammatory disease of the CNS that leads to demyelinated lesions in the grey and white matter. Inflammatory,
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01.07.2020

The human box C/D snoRNA U3 is a miRNA source and miR-U3 regulates expression of sortin nexin 27

Authors Lemus-Diaz N, Ferreira RR, Bohnsack KE, Gruber J, Bohnsack MT Journal Nucleic Acids Research Citation Nucleic Acids Res. 2020;gkaa549. published online ahead of print, 2020 Jul 1. Abstract MicroRNAs (miRNAs) are important regulators of eukaryotic gene expression and their dysfunction is often associated with cancer. Alongside the canonical miRNA
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