2025

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22.07.2025

3D multiscale shape analysis of nuclei and in vivo elastic stress sensors allows force inference

Authors Jurado A, Isensee J, Hofemeier A, Krüger LJ, Wittkowski R, Golestanian R, Bittihn P, Betz T Journal Biophysical Journal Citation Biophys J. 2025 Jul 22:S0006-3495(25)00450-3. Abstract The measurement of stresses and forces at the tissue level has proven to be an indispensable tool for the understanding of complex biological
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22.07.2025

3D multiscale shape analysis of nuclei and in-vivo elastic stress sensors allows force inference

Authors Jurado A, Isensee J, Hofemeier A, Krüger LJ, Wittkowski R, Golestanian R, Bittihn P, Betz T Journal Biophysical Journal Citation Biophys J. 2025 Jul 22:S0006-3495(25)00450-3. Abstract The measurement of stresses and forces at the tissue level has proven to be an indispensable tool for the understanding of complex biological
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Prof. Dr. Dr. Tobias Brügmann, University Medical Center Göttingen Photo: MBExC

21.07.2025

New DFG research unit

MBExC member Prof. Dr. Dr. Tobias Brügmann from the University Medical Center Göttingen has helped establish the new DFG research unit, ‘Dynamic Integration of GPCR signaling to control organ function and animal behaviour’. The DFG is funding the group for four years with 5 million euros.   Link to DZHK
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19.07.2025

Photoactivatable and Photolabile Pharmacophores: Lessons Learned from Capsaicin

Authors Imse B, Rojas L, Herrero CG, Thallmair S, Rhee JS, Simeth N Journal RSC Chemical Biology Citation RSC Chem Biol. 2025 Jul 19. Abstract Light-controlled molecules have become valuable tools for studying biological systems offering an unparalleled control in space and time. Specifically, the remote-controllable (de)activation of small molecules
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Professor Timo Betz and Professor Jörg Enderlein, University of Göttingen. Photos: MBExC.

14.07.2025

Timo Betz and Jörg Enderlein received ERC Proof of Concept grants

MBExC members Timo Betz and Jörg Enderlein, both from University of Göttingen,have each been awarded Proof of Concept (PoC) grants by the European Research Council (ERC). These grants provide top-up funding to outstanding researchers, who have already received ERC funding, so that they can build on the innovation potential of
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14.07.2025

Circadian clock dysfunction in Parkinson’s disease: mechanisms, consequences, and therapeutic strategy

Authors Yalçin M, Grande V, Outeiro TF, Relόgio A Journal NPJ Parkinsons Disease Citation NPJ Parkinsons Dis. 2025 Jul 14;11(1):213. Abstract Parkinson’s Disease (PD) is a prevalent neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra. This leads to hallmark motor features that include bradykinesia,
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12.07.2025

Highly adaptable deep-learning platform for automated detection and analysis of vesicle exocytosis

Authors Chouaib AA, Chang HF, Khamis OM, Alawar N, Echeverry S, Demeersseman L, Elizarova S, Daniel JA, Tian Q, Lipp P, Fornasiero EF, Valitutti S, Barg S, Pape C, Shaib AH, Becherer U Journal Nature Communications Citation Nat Commun. 2025 Jul 12;16(1):6450. Abstract Activity recognition in live-cell imaging is labor-intensive
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11.07.2025

Autonomous bioluminescence emission from transgenic mice

Authors Kiszka KA, Dullin C, Steffens H, Koenen T, Rothermel E, Alves F, Gregor C Journal Science Advances Citation Sci Adv. 2025 Jul 11;11(28):eads0463. Abstract The bacterial bioluminescence system can be applied to produce autonomous bioluminescence in mammalian cells. Until now, the system has only been stably inserted into cells
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10.07.2025

Super-resolution microscopy of mitochondrial mRNAs

Authors Stoldt S, Maass F, Weber M, Dennerlein S, Ilgen P, Gaertner J, Canfes A, Schweighofer SV, Jans DC, Rehling P, Jakobs S Journal Nature Communications Citation Nat Commun. 2025 Jul 10;16(1):6391. Abstract Mitochondria contain their own DNA (mtDNA) and a dedicated gene expression machinery. As the mitochondrial dimensions are
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10.07.2025

Avoidance engages dopaminergic punishment in Drosophila

Authors Amin F, Stone JT, König C, Mancini N, Murakami K, Bidaye SS, Heim MM, Owald D, Majumder U, Grunwald Kadow IC, Pierzchlińska A, Litwin-Kumar A, Barnstedt O, Gerber B Journal BioRxiv Citation bioRxiv 2025.07.07.663268. Abstract It was classically suggested that behaviour can cause emotions (Darwin 1872). For example, smiling
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