2025

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20.01.2025

MedicoSAM: Towards foundation models for medical image segmentation

Authors Archit A, Freckmann L, Pape C Journal Arxiv Citation arXiv:2501.11734. Abstract Medical image segmentation is an important analysis task in clinical practice and research. Deep learning has massively advanced the field, but current approaches are mostly based on models trained for a specific task. Training such models or adapting
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17.01.2025

Lipidic folding pathway of α-Synuclein via a toxic oligomer

Authors Sant V, Matthes D, Mazal H, Antonschmidt L, Wieser F, Movellan KT, Xue K, Nimerovsky E, Stampolaki M, Nathan M, Riedel D, Becker S, Sandoghdar V, de Groot BL, Griesinger C, Andreas LB Journal Nature Communications Citation Nat Commun. 2025 Jan 17;16(1):760. Abstract Aggregation intermediates play a pivotal role
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Minister President Stephan Weil (left) and Prof. Dr Dr h.c. mult. Stefan W. Hell

16.01.2025

Stefan Hell honored with Landesmedaille of Lower Saxony

MBExC member Stefan Hell receives the highest award from the state of Lower Saxony for his many years of scientific achievements and his outstanding contribution to the research landscape in Lower Saxony. Minister President Stephan Weil presented Hell with the medal on 16 January in Hanover.   Link to the
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16.01.2025

Super-resolution going viral: T4 virus particles as versatile 3D-Bio-NanoRulers

Authors Gallea JI, Nevskyi O, Kaźmierczak Z, Gligonov I, Chen T, Miernikiewicz P, Chizhik AM, Reinkensmeier L, Dąbrowska K, Bates M, Enderlein J Journal Advanced Materials Citation Adv Mater. 2025 Jan 16:e2403365. Abstract In the burgeoning field of super-resolution fluorescence microscopy, significant efforts are being dedicated to expanding its applications
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15.01.2025

Phenotypes linked to duplication upstream of SOX9: New insights into presentation and diagnosis

Authors Unal E, Tekmenuray-Unal A, Cayir A, Papatya Cakir ED, Beyazit N, Kolbasi B, Gurpinar Tosun B, Yigit G, Zibat A, Wollnik B, Demirbilek H, Guran T Journal The Journal of Clinical Endocrinology and Metabolism Citation J Clin Endocrinol Metab. 2025 Jan 15:dgaf020. Abstract Context: Duplications occurring upstream of the
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14.01.2025

Single neuron diversity supports area functional specialization along the visual cortical pathways

Authors Feyerabend M, Pommer S, Jimenez-Sosa MS, Rachel J, Sunstrum JK, Preuss F, Mestern S, Hinkel R, Mietsch M, Viyajraghavan S, Everling S, Treue S, Arnsten AFT, Lewis DA, Wolf F, Murray J, Muller L, McCarroll S, Krienen F, Datta D, Jing Wang X, Tripathy S, Gonzalez-Burgos G, Inoue W,
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10.01.2025

Super-resolution optical fluctuation imaging

Authors Basak S, Chizhik A, Gallea JI, Gligonov I, Gregor I, Nevskyi O, Radmacher N, Tsukanov R, Enderlein J Journal Nature Photonics Citation Nat. Photon. (2025) Abstract We present a comprehensive review of super-resolution optical fluctuation imaging (SOFI), a robust technique that leverages temporal fluctuations in fluorescence intensity to achieve
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09.01.2025

LncRNA 3222401L13Rik Is Upregulated in Aging Astrocytes and Regulates Neuronal Support Function Through Interaction with Npas3

Authors Schröder S, Sakib MS, Krüger DM, Pena T, Burkhardt S, Schütz AL, Sananbenesi F, Fischer A Journal Noncoding RNA Citation Noncoding RNA. 2025 Jan 9;11(1):2. Abstract Aging leads to cognitive decline and increased risk of neurodegenerative diseases. While molecular changes in central nervous system (CNS) cells contribute to this
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09.01.2025

Cardiovascular MRI-derived Right Atrial Strain for Improved Risk Stratification in Patients with Severe Aortic Stenosis

Authors Lange T, Beuthner BE, Schulz A, Backhaus SJ, Evertz R, Rigorth KR, Toischer K, Kowallick JT, Hasenfuss G, Puls M, Schuster A Journal Radiology: Cardiothoracic Imaging Citation Radiol Cardiothorac Imaging. 2025 Feb;7(1):e230380. Abstract Purpose: To assess the prognostic implications of cardiac MRI-derived imaging markers in individuals with severe aortic
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Prof. Dr. Tim Gollisch (left) and Dr. Dimokratis Karamanlis (right), Department of Ophthalmology at the University Medical Center Göttingen (UMG). Photo: Mohammad Khani

09.01.2025

Nerve cells in the eye work together to recognise contrasts and movements

Researchers at the University Medical Center Göttingen (UMG) have discovered that nerve cells in the eye often process natural visual stimuli from the environment together in cell groups and in a coordinated manner. The coordinated co-operation of nerve cells enhances signal transmission in scenes with high contrast and movement. These
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