2025

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06.09.2025

Mitochondrial proteostatic stress disrupts mitoribosome biogenesis and translation

Authors Holthusen H, Trinkaus VA, Fernandez Gonzalez C, Saha I, Pachmayr I, Wade OK, Dieser A, Hummel B, Yuste-Checa P, Ehses K, Körner R, Fernández-Busnadiego R, Sawarkar R, Jungmann R, Hipp MS, Hartl FU Journal BioRxiv Citation bioRxiv 2025.09.05.673478. Abstract Protein aggregation in various cellular compartments is a hallmark of
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05.09.2025

Uncoupling of CSF biomarkers and clinical status in patients with a novel mutation of ATP13a2

Authors Stephani C, Ewers D, Stausberg D, Rasche D, Bahiraee A, Ahmad B, Baehr M, Downie B, Hirschel S, Pauli SJ, Riedel C, Sachkova A, Salinas G, Schneider A, van Riesen C, Wollnik B, Yigit G, Nave K, Zerr I, Eggert S, Sereda MW Journal MedRxiv Citation medRxiv 2025.09.02.25334661. Abstract
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04.09.2025

A Novel α-Synuclein K58N Missense Variant in a Patient with Parkinson’s Disease

Authors Al-Azzani M, Weber S, Ramalingam N, Ramón M, Shvachiy L, Mestre G, Zech M, Sicking K, de Opakua AI, Jayanthi V, Amaral L, Agarwal A, Chandran A, Chaves SR, Winkelmann J, Trenkwalder C, Schwager M, Pauli S, Dettmer U, Fernández CO, Lautenschläger J, Zweckstetter M, Busnadiego RF, Mollenhauer B,
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Dr. Oliver Barnstedt, junior research group leader for “Multiscale Circuit Analysis” at the European Neuroscience Institute (ENI), University Medical Center Göttingen. Photo: Robin Ritter.

04.09.2025

Oliver Barnstedt receives ERC Starting Grant

MBExC member and Neuroscientist Dr. Oliver Barnstedt from the European Neuroscience Institute Göttingen (ENI-G) receives an ERC Starting Grant for his project “LearnMamBo: Neuronal dynamics of learning and memory in the mammillary body“. This projects will run for five years with a budget of around 1.5 million euros.   You
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Dr. Oliver Barnstedt, junior research group leader for “Multiscale Circuit Analysis” at the European Neuroscience Institute (ENI), University Medical Center Göttingen. Photo: Robin Ritter.

04.09.2025

International awards for researchers at the Göttingen Campus

Dr. Oliver Barnstedt and Dr. Anggi Hapsari each receive an ERC Starting Grant   Two researchers at the Göttingen Campus have been awarded ERC Starting Grants by the European Research Council (ERC). MBExC member and Neuroscientist Dr. Oliver Barnstedt from the European Neuroscience Institute Göttingen (ENI-G) receives funding for his
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03.09.2025

Adaptor protein complex 2 (AP2) participates in biogenesis and homeostasis of myelin sheaths in the central nervous system

Authors Siems SB, Jung RB, Jahn O, Meschkat M, Michanski S, Lukasik N, Hummert S, Sasmita AO, Mobius W, Benseler F, Brose N, Kramer-Albers EM, Haucke V, Nave KA, Werner HB Journal BioRxiv Citation bioRxiv 2025.09.02.673641. Abstract Myelination of CNS axons requires oligodendrocytes to undergo extensive morphological changes by producing
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28.08.2025

Role of Structural Versus Cellular Remodeling in Atrial Arrhythmogenesis: Insights From Personalized Digital Twins

Authors Pikunov AV, Syunyaev RA, Ali R, Prakosa A, Gams A, Boyle PM, Steckmeister V, Kutschka I, Rytkin E, Voigt N, Trayanova N, Efimov IR Journal Circulation: Arrhythmia and Electrophysiology Citation Circ Arrhythm Electrophysiol. 2025 Aug 28:e013898. Abstract Background: Atrial fibrillation (AF) is a progressive disease involving both structural and
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28.08.2025

SynapseNet: Deep Learning for Automatic Synapse Reconstruction

Authors Muth S, Moschref F, Freckmann L, Mutschall S, Hojas-Garcia-Plaza I, Bahr JN, Petrovic A, Do TT, Schwarze V, Archit A, Weyand K, Michanski S, Maus L, Imig C, Hintze A, Brose N, Wichmann C, Fernandez-Busnadiego R, Moser T, Rizzoli SO, Cooper BH, Pape C Journal Molecular Biology of the
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28.08.2025

Translational repression by 4E-T is crucial to maintain the prophase-I arrest in vertebrate oocytes

Authors Heim A, Cheng S, Orth J, Stengel F, Schuh M, Mayer TU Journal Nature Communications Citation Nat Commun. 2025 Aug 28;16(1):8051. Abstract Meiotic maturation of vertebrate oocytes occurs in the near-absence of transcription. Thus, female fertility relies on timely translational activation of maternal transcripts stockpiled in full-grown prophase-I-arrested oocytes.
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26.08.2025

A spatiotemporal atlas of mouse gastrulation and early organogenesis to explore axial patterning and project in vitro models onto in vivo space

Authors Harland LTG, Lohoff T, Koulena N, Pierson N, Pape C, Ameen F, Griffiths J, Theeuwes B, Wilson NK, Kreshuk A, Reik W, Nichols J, Cai L, Marioni JC, Göttgens B, Ghazanfar S Journal Cell Reports Citation Cell Rep. 2025 Aug 26;44(8):116047. Abstract During gastrulation, mouse epiblast cells form the
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