2025

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01.10.2025

3D histology of human heart-forming organoids by X-ray phase-contrast tomography

Authors Komorowski K, Reichmann J, Drakhlis L, Zweigerdt R, Salditt T Journal Communications Biology Citation Commun Biol. 2025 Oct 1;8(1):1411. Abstract Three-dimensional (3D) imaging is crucial for elucidating the complex structure of organoid models which involve complex spatial cellular and tissue organization in 3D. While a variety of volume imaging
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01.10.2025

3D imaging of neuronal inclusions and protein aggregates in human neurodegeneration by multiscale X-ray phase-contrast tomography

Authors Franz J, Reichmann J, Eckermann M, Würfel T, Groh A, Qadri SF, Schulz K, Mollenhauer B, Stadelmann C, Salditt T   Journal Brain Pathology   Citation Brain Pathol. 2025 Oct 1:e70044.   Abstract This study leverages x-ray phase-contrast tomography (XPCT) for detailed analysis of neurodegenerative diseases, focusing on the
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30.09.2025

Pharmacological inhibition of V-ATPase targets mode-switching but not the proton transport cycle

Authors Kosmidis E, Fokaeos M, Shuttle CG, Isselstein MC, Cvjetkovic A, Johnson PJ, Pederesen JL, Jahn R, Preobraschenski J, Stamou D Journal BioRxiv Citation bioRxiv 2025.09.28.679038. Abstract Vacuolar-type adenosine triphosphatases (V-ATPases) are rotary proton pumps that establish proton gradients across cellular membranes. Their pharmacological inhibition is currently under active investigation
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26.09.2025

A novel alpha-synuclein G14R missense variant is associated with atypical neuropathological features

Authors Brücke C, Al-Azzani M, Ramalingam N, Ramón M, Sousa RL, Buratti F, Zech M, Sicking K, Amaral L, Gelpi E, Chandran A, Agarwal A, Chaves SR, Fernández CO, Dettmer U, Lautenschläger J, Zweckstetter M, Busnadiego RF, Zimprich A, Outeiro TF Journal Molecular Neurodegeneration Citation Mol Neurodegener. 2025 Sep 26;20(1):98.
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Dr. Stefan Kallenberger, BioQuant Center at Heidelberg University, Dr. Judith Gronwald, Department of Cardiology and Pneumology at UMG, and Dr. Funsho E. Fakuade, Institute of Pharmacology and Toxicology at UMG, and Prof. Dr. Niels Voigt, Institute of Pharmacology and Toxicology at UMG (from left to right). Photo: umg/eva meyer-besting

23.09.2025

Calcium improves the ability to predict dangerous cardiac arrhythmias after heart surgery

Researchers from Göttingen University Medical Center (UMG) and Heidelberg University Hospital (UKHD) have collaborated under the leadership of MBExC member Prof. Dr. Niels Voigt, Professor of Molecular Pharmacology at the Institute of Pharmacology and Toxicology at UMG, and Dr. Dr. Stefan Kallenberger, Head of the Systems Medicine Working Group at
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19.09.2025

High throughput automated patch-clamp of cardiac ion channels using physiological fluoride-free internal solution

Authors Rapedius M, Obergrussberger A, Scholz S, Rinke-Weiss I, Goetze TA, Brinkwirth N, Rotordam MG, Strassmaier T, Randolph A, Friis S, Yang K, Rathje J, Liutkute A, Seibertz F, Voigt N, Fertig N, Stoelzle-Feix S Journal Journal of Pharmacological and Toxicological Methods Citation J Pharmacol Toxicol Methods. 2025. 135, 107825.
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17.09.2025

Optimal Transport Based Testing in Factorial Design

Authors Groppe M, Niemöller L, Hundrieser S, Ventzke D, Blob A, Köster S, Munk A Journal Arxiv Citation arXiv:2509.13970. Abstract We introduce a general framework for testing statistical hypotheses for probability measures supported on finite spaces, which is based on optimal transport (OT). These tests are inspired by the analysis
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17.09.2025

Charting the nanotopography of inner hair cell synapses using MINFLUX nanoscopy

Authors Kapoor R, Kim H, Garlick E, Lima MARBF, Ruhwedel T, Moebius W, Wolf F, Moser T Journal Science Advances Citation Science Advances. 2025. accepted manuscript. Abstract For us to hear, the cochlea encodes sounds into neural signals at synapses of inner hair cells (IHCs) and the auditory nerve with
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Prof. Dr. Melina Schuh © Irene Böttcher-Gajewski / Max Planck Institute for Multidisciplinary Sciences.

16.09.2025

Melina Schuh honored with Science Breakthrough 2025

MBExC member Melina Schuh, director at the Max Planck Institute (MPI) for Multidisciplinary Sciences and her team filmed the entire ovulation process in mouse follicles in real-time for the first time. For this decisive success in her field, she has been awarded the 2025 Science Breakthrough by the Falling Walls
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15.09.2025

Manipulating mitochondrial gene expression

Authors Dahal D, Cruz-Zargoza LD, Rehling P Journal Biological Chemistry Citation Biol Chem. 2025 Sep 15. Abstract Mitochondria are essential for cellular metabolism, serving as the primary source of adenosine triphosphate (ATP). This energy is generated by the oxidative phosphorylation (OXPHOS) system located in the inner mitochondrial membrane. Impairments in
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