2025

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Schematic representation of otoferlin with a ring-shaped arrangement of its individual C2 domains (shown in colour on the left and right) and one transmembrane domain (light blue) each, which anchors otoferlin in the synaptic vesicle (shown as a grey semicircle). Through the interaction of otoferlin with the cell membrane (grey area at the bottom of the image), the synaptic vesicle ‘docks’ onto the membrane and changes its structure (indicated by the coloured circles on the left and right at the bottom of the image). This process leads to the fusion of the two membranes (indicated by the white circles at the bottom centre of the image). Image: umg/alexey chizhik

17.10.2025

Early childhood deafness – Researchers at Göttingen Campus decipher structure and function of a key hearing protein

Researchers in Göttingen have elucidated the structure and function of otoferlin, a protein that plays a crucial role in the hearing process. If otoferlin is missing or its function is impaired, this causes a common form of early childhood deafness. The results, published in the journal Science Advances, mark a
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16.10.2025

Nanoscale architecture and dynamics of CaV1.3 channel clusters in cardiac myocytes revealed by single channel nanoscopy

Authors Schwenzer N, Tsukanov R, Kohl T, Basak S, Sobitov I, Seibertz F, Kapoor R, Voigt N, Enderlein J, Lehnart SE   Journal Journal of Molecular and Cellular Cardiology Plus   Citation J Mol Cell Cardiol Plus. 2025 Oct 16;14:100490.   Abstract The clustering of L-type calcium channels (LTCC) for
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15.10.2025

Persistence of vestibular function in the absence of glutamatergic transmission from hair cells

Authors Mukhopadhyay M, Modgekar R, Yang-Hood A, Ohlemiller KK, Militchin V, Xiao M, Shen Z, Rensing NR, Wong M, Lee SJ, Seal RP, Warchol ME, Maloney SE, Yuede CM, Rutherford MA, Pangrsic T Journal BioRxiv Citation bioRxiv 2025.10.15.682551. Abstract Quantal synaptic transmission in vestibular end-organs is glutamatergic. Although genetic deletion
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15.10.2025

Uncovering Dual Molecular Diagnoses in Families with Complex Phenotypes through Structural and Clinical Study of Novel COL4A6 Variants

Authors Owrang D, Rad A, Cretu C, Lin SJ, Mustafa HM, Huang K, Waheed N, Hussain M, Riaz S, Preobraschenski J, Varshney GK, Oprea G, Vona B Journal QJM: An International Journal of Medicine Citation QJM. 2025 Oct 15:hcaf246. Abstract Background: The relationship between observed clinical phenotypes and underlying genotypes
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15.10.2025

Impaired Atrial Mitochondrial Calcium Handling in Patients With Atrial Fibrillation

Authors Pronto JRD, Mason FE, Rog-Zielinska EA, Fakuade FE, Bülow D, Tóth M, Machwart K, Brandes P, Wiedmann F, Kohlhaas M, Nickel A, Wolf M, Mustroph J, Vu KC, Brandenburg S, Do TQ, Siedler PJ, Ritzenhoff K, Xue Z, Zhou X, Kestel S, Dschun O, Kyshynska O, Kensah G, Rebbeck
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13.10.2025

Peroxisome protein import deficiency causes heart failure in mouse and human

Authors Hofhuis J, Tiburcy M, Hartmann Y, Bersch K, Wagdi A, Gutiérrez-Gutiérrez O, Solano R, Thiele L, Walper M, Göbel M, Hübner W, Berecic B, Casini M, Tirilomis P, Unger A, Lipstein N, Sossalla S, Huser T, Streckfuss-Bömeke K, Elkenani M, Toischer K, Kohlhaas M, Dudek J, Zimmermann WH, Voigt
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08.10.2025

Expected and Unexpected “Guests” at the Active Site of Human Orotidine 5′-Monophosphate Decarboxylase

Authors Kirck LL, Santagostino E, Brandhoff L, Simeth NA, Tittmann K Journal Biochemistry Citation Biochemistry. 2025 Oct 8. Abstract With an extraordinary rate enhancement of 1017 compared to the uncatalyzed reaction and no need for a cofactor, orotidine 5′-monophosphate decarboxylase (OMPDC) is considered one of the most efficient enzymes. Its
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07.10.2025

Weak convergence of Bayes estimators under general loss functions

Authors Requadt R, Li H, Munk A Journal Arxiv Citation arXiv:2510.05645. Abstract We investigate the asymptotic behavior of parametric Bayes estimators under a broad class of loss functions that extend beyond the classical translation-invariant setting. To this end, we develop a unified theoretical framework for loss functions exhibiting locally polynomial
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07.10.2025

Mapping complex optical light field distributions with single fluorescent molecules

Authors Marx D, Gligonov I, Malsbenden D, Wöll D, Nevskyi O, Enderlein J Journal Arxiv Citation arXiv:2510.05791. Abstract Single fluorescent molecules, behaving as ideal electric dipole emitters, are powerful nanoscopic probes of complex optical fields. Here, this property is exploited to precisely map the polarization and vectorial structure of tightly
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07.10.2025

A versatile microfluidics platform for enhanced multi-target super-resolution microscopy

Authors Basak S, Chi-Vu K, Mougios N, Oleksiievets N, Pollack Y, Brandenburg S, Opazo F, Lehnart SE, Enderlein J, Tsukanov R Journal BioRxiv Citation bioRxiv 2025.10.07.680900. Abstract DNA-based Point Accumulation for Imaging in Nanoscale Topography (DNA-PAINT) is a powerful variant of single-molecule localization microscopy (SMLM) that overcomes the limitations of
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