2025

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25.10.2025

The Myo2 adaptor Ldm1 and its receptor Ldo16 mediate actin-dependent lipid droplet motility

Authors Zhao XT, Diep DTV, Percifull L, Fausten RM, Hugenroth M, Höhne P, Leite B, Esch BM, Collado J, Keller J, Wilmes S, Turhan MA, Wälte M, Becker T, Kümmel D, Schuberth C, Fernández-Busnadiego R, Fröhlich F, Wedlich-Söldner R, Bohnert M Journal Cell Reports Citation Cell Rep. 2025 Oct 25;44(11):116475.
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24.10.2025

EXOSC10 haploinsufficiency causes primary microcephaly by derepression of Sonic hedgehog signalling

Authors Ulmke PA, Sakib MS, Nguyen DT, Muchamedin A, Sokpor G, Pham L, Xie Y, Abbas E, Castro Hernandez R, Narayanan R, Wincent J, Liedén A, Harris E, Joss S, Fischer A, Staiger JF, Nguyen HP, Tuoc T Journal Brain Citation Brain. 2025 Oct 24:awaf405. Abstract The evolutionarily conserved RNA
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23.10.2025

Glycation of alpha-synuclein enhances aggregation and neuroinflammatory responses

Authors Vasili E, König A, Al-Azzani M, Bosbach C, Gatzemeier LM, Thom S, Chegão A, Miranda HV, Steinem C, Erskine D, Outeiro TF Journal NPJ Parkinsons Disease Citation NPJ Parkinsons Dis. 2025 Oct 23;11(1):307. Abstract The risk of developing Parkinson’s disease (PD) is elevated in individuals with type 2 diabetes
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23.10.2025

International expert consensus on gene therapy for hereditary hearing loss: based on clinical trials

Authors Fan X, Gao Z, Zhong J, Chen Y, Chen X, Landegger LD, Moser T, Zeng FG, Sun Y, Jin X, Nash R, Chien WW, Jiang D, Greinwald JH, Bance M, Rodríguez MM, Lee SY, Feng G, Yang H, Wu CC, Xu L, Yuan W, Feng Y, Zhao Y, Vona
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Nerve cells (green) form neural networks in which information is transmitted. Errors in this communication can lead to neurodegenerative, neurological, and neuropsychiatric diseases. © Pia Venneker / Leibniz-Forschungsinstitut für Molekulare Pharmakologie

22.10.2025

New developmental disorder discovered

Variations in the UNC13A gene cause neurological impairments in children   Whether we are writing an email, rushing for a bus, or humming a tune, every thought, feeling, and action relies on communication between our roughly 100 billion nerve cells. This exchange of information happens at synapses, where messenger substances
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22.10.2025

Pathogenic UNC13A variants cause a neurodevelopmental syndrome by impairing synaptic function

Authors Asadollahi R, Ahmad A, Boonsawat P, Shahanoor Hinzen J, Lohse M, Bouazza-Arostegui B, Sun S, Utesch T, Sommer JD, Ilic D, Padmanarayana M, Fischermanns K, Ranjan M, Boll M, Ka C, Piton A, Mattioli F, Isidor B, Õunap K, Reinson K, Wojcik MH, Marshall CR, Mercimek-Andrews S, Matsumoto N,
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22.10.2025

Phosphoproteomic identification of Mos-MAPK targets in meiotic cell cycle and asymmetric oocyte divisions

Authors Avilov I, Horokhovskyi Y, Mehta P, Welp L, Jakobi J, Cai M, Orzechowski A, Urlaub H, Liepe J, Lenart P Journal Journal of Cell Biology Citation J Cell Biol. 2025 Dec 1;224(12):e202312140. Abstract The Mos kinase activates the ERK/MAPK pathway during oocyte meiosis, controlling essential meiotic functions in species
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20.10.2025

Probing the role of synaptic adhesion molecule RTN4RL2 in setting up cochlear connectivity

Authors Karagulyan N, Überegger M, Qi Y, Babai N, Hofer F, Johnson Chacko L, Wang F, Luque M, Glueckert R, Schrott-Fischer A, Hua Y, Moser T, Bandtlow C Journal eLife Citation Elife. 2025 Oct 20;14:RP103481 Abstract Sound encoding depends on the precise and reliable neurotransmission at the afferent synapses between
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17.10.2025

Structure and function of otoferlin, a synaptic protein of sensory hair cells essential for hearing

Authors Chen H, Cretu C, Trebilcock A, Evdokimova N, Babai N, Feldmann L, Leidner F, Benseler F, Mutschall S, Esch K, Szabo CZK, Pena V, Pape C, Grubmüller H, Strenzke N, Brose N, Wichmann C, Preobraschenski J, Moser T Journal Sciende Advances Citation Sci Adv. 2025 Oct 17;11(42):eady8532. Abstract Hearing
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Prof. Dr. Tobias Moser, Director of the Institute for Auditory Neuroscience at Göttingen University Medical Center (UMG), spokesperson for the Göttingen Cluster of Excellence “Multiscale Bioimaging: From Molecular Machines to Networks of Excitable Cells” (MBExC) and spokesperson for the Collaborative Research Center (SFB) 1690 “Disease Mechanisms and Functional Restoration of Sensory and Motor Systems” (left; photo: umg/frank stefan kimmel), and Dr. Han Chen, former research associate at the Institute of Auditory Neuroscience at UMG (right; photo: han chen).

17.10.2025

Early childhood deafness – researchers at Göttingen Campus decipher structure and function of a key hearing protein

Researchers in Göttingen have elucidated the structure and function of otoferlin, a protein that plays a crucial role in the hearing process. If otoferlin is missing or its function is impaired, this causes a common form of early childhood deafness. The results, published in the journal Science Advances, mark a
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