2025

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28.08.2025

SynapseNet: Deep Learning for Automatic Synapse Reconstruction

Authors Muth S, Moschref F, Freckmann L, Mutschall S, Hojas-Garcia-Plaza I, Bahr JN, Petrovic A, Do TT, Schwarze V, Archit A, Weyand K, Michanski S, Maus L, Imig C, Hintze A, Brose N, Wichmann C, Fernandez-Busnadiego R, Moser T, Rizzoli SO, Cooper BH, Pape C Journal Molecular Biology of the
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28.08.2025

Translational repression by 4E-T is crucial to maintain the prophase-I arrest in vertebrate oocytes

Authors Heim A, Cheng S, Orth J, Stengel F, Schuh M, Mayer TU Journal Nature Communications Citation Nat Commun. 2025 Aug 28;16(1):8051. Abstract Meiotic maturation of vertebrate oocytes occurs in the near-absence of transcription. Thus, female fertility relies on timely translational activation of maternal transcripts stockpiled in full-grown prophase-I-arrested oocytes.
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25.08.2025

Blebbistatin reduces calcium buffering in cardiomyocytes: Consequences for cellular electrophysiology

Authors Sobitov I, Ritzenhoff K, Gaulrapp M, Becker L, Liutkute A, Seibertz F, Fakuade FE, Mason FE, Voigt N Journal The Journal of Physiology Citation J Physiol. 2025 Aug 25 Abstract Blebbistatin is an excitation-contraction uncoupling agent commonly used in cardiac optical mapping; however, it has been reported to influence
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22.08.2025

Online jump and kink detection in segmented linear regression: Statistical optimality meets computational efficiency

Authors Hüselitz A, Li H, Munk A Journal Arxiv Citation arXiv:2503.05270. Abstract We consider the problem of sequential (online) estimation of a single change point in a piecewise linear regression model under a Gaussian setup. We demonstrate that certain CUSUM-type statistics attain the minimax optimal rates for localizing the change
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22.08.2025

Seeing the heart in 3-D: Mapping arrhythmias across modalities

Authors Zgierski-Johnston CM, Huisken J Journal The Journal of Physiology Citation J Physiol. 2025 Aug 22 Abstract No abstract available. DOI 10.1113/JP289664   Pubmed Link  
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19.08.2025

Developmental plasticity facilitates the structural maturation of cochlear inner hair cell ribbon synapses

Authors Voorn RA, Sternbach M, Bourien J, Komiyama N, Rankovic V, Wolf F, Grant SGN, Vogl C Journal BioRxiv Citation bioRxiv 2025.08.19.671016 Abstract Sound detection occurs in the cochlea, where sensory inner hair cells (IHC) accurately convert auditory stimuli into neurochemical signals. Presynaptically, IHCs harbor synaptic ribbons, specialized scaffolds that
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19.08.2025

Proteo-transcriptomic reprogramming and resource reallocation define the aging mammalian brain

Authors Kumar NH, Kluever V, Kaufmann SV, Bergmann C, Mousaei K, Tomas M, Marrero MC, Chopra A, Hirose M, Pallas M, Sanfeliu C, Ibrahim SM, Fischer A, Outeiro TF, Urlaub H, Tchumatchenko T, Lopez Otin C, Fornasiero EF Journal BioRxiv Citation bioRxiv 2025.08.14.669896 Abstract Brain aging is a major risk
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18.08.2025

Introduction to photoswitches and photopharmacology

Authors Cacciarini M, Woolley GA, Szymanski W, Simeth NA Journal Organic & Biomolecular Chemistry Citation Org Biomol Chem. 2025 Aug 18. Abstract No abstract available. DOI 10.1039/d5ob90098k   Pubmed Link  
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18.08.2025

Super-Resolution Axial Imaging for Quantifying Piconewton Traction Forces in Live Cells

Authors Wang DX, Gallea JI, Kong DM, Enderlein J, Chen T Journal Angewandte Chemie (International ed. in Engl.) Citation Angew Chem Int Ed Engl. 2025 Aug 18:e202506864. Abstract Cell mechanics play a pivotal role in regulating numerous biological processes. Although super-resolution microscopy enables the imaging of cellular forces in the
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18.08.2025

Direct mechanical communication of cellular to nuclear shape in oocytes

Authors Vos BE, Vadapalli Y, Muenker TM, Astad Jentoft IM, Todisco E, Eskandari MA, Schuh M, Lenart P, Betz T Journal Biophysical Journal Citation Biophys J. 2025 Aug 18:S0006-3495(25)00524-7. Abstract The mechanical properties of the cytoplasm and nucleoplasm are crucial for the correct and robust functioning of a cell and
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