September

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29.09.2025

International expert consensus on gene therapy for hereditary hearing loss: based on clinical trials

Authors Fan X, Gao Z, Zhong J, Chen Y, Chen X, Landegger LD, Moser T, Zeng FG, Sun Y, Jin X, Nash R, Chien WW, Jiang D, Greinwald JH, Bance M, Rodriguez MM, Lee SY, Feng G, Yang H, Wu CC, Xu L, Yuan W, Feng Y, Zhao Y, Vona
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26.09.2025

A novel alpha-synuclein G14R missense variant is associated with atypical neuropathological features

Authors Brücke C, Al-Azzani M, Ramalingam N, Ramón M, Sousa RL, Buratti F, Zech M, Sicking K, Amaral L, Gelpi E, Chandran A, Agarwal A, Chaves SR, Fernández CO, Dettmer U, Lautenschläger J, Zweckstetter M, Busnadiego RF, Zimprich A, Outeiro TF Journal Molecular Neurodegeneration Citation Mol Neurodegener. 2025 Sep 26;20(1):98.
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Dr. Stefan Kallenberger, BioQuant Center at Heidelberg University, Dr. Judith Gronwald, Department of Cardiology and Pneumology at UMG, and Dr. Funsho E. Fakuade, Institute of Pharmacology and Toxicology at UMG, and Prof. Dr. Niels Voigt, Institute of Pharmacology and Toxicology at UMG (from left to right). Photo: umg/eva meyer-besting

23.09.2025

Calcium improves the ability to predict dangerous cardiac arrhythmias after heart surgery

Researchers from Göttingen University Medical Center (UMG) and Heidelberg University Hospital (UKHD) have collaborated under the leadership of MBExC member Prof. Dr. Niels Voigt, Professor of Molecular Pharmacology at the Institute of Pharmacology and Toxicology at UMG, and Dr. Dr. Stefan Kallenberger, Head of the Systems Medicine Working Group at
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17.09.2025

Optimal Transport Based Testing in Factorial Design

Authors Groppe M, Niemöller L, Hundrieser S, Ventzke D, Blob A, Köster S, Munk A Journal Arxiv Citation arXiv:2509.13970. Abstract We introduce a general framework for testing statistical hypotheses for probability measures supported on finite spaces, which is based on optimal transport (OT). These tests are inspired by the analysis
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17.09.2025

Charting the nanotopography of inner hair cell synapses using MINFLUX nanoscopy

Authors Kapoor R, Kim H, Garlick E, Lima MARBF, Ruhwedel T, Moebius W, Wolf F, Moser T Journal Science Advances Citation Science Advances. 2025. accepted manuscript. Abstract For us to hear, the cochlea encodes sounds into neural signals at synapses of inner hair cells (IHCs) and the auditory nerve with
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Prof. Dr. Melina Schuh © Irene Böttcher-Gajewski / Max Planck Institute for Multidisciplinary Sciences.

16.09.2025

Melina Schuh honored with Science Breakthrough 2025

MBExC member Melina Schuh, director at the Max Planck Institute (MPI) for Multidisciplinary Sciences and her team filmed the entire ovulation process in mouse follicles in real-time for the first time. For this decisive success in her field, she has been awarded the 2025 Science Breakthrough by the Falling Walls
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15.09.2025

Manipulating mitochondrial gene expression

Authors Dahal D, Cruz-Zargoza LD, Rehling P Journal Biological Chemistry Citation Biol Chem. 2025 Sep 15. Abstract Mitochondria are essential for cellular metabolism, serving as the primary source of adenosine triphosphate (ATP). This energy is generated by the oxidative phosphorylation (OXPHOS) system located in the inner mitochondrial membrane. Impairments in
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11.09.2025

Charge-Dependent Fluorescence Lifetime Modulation in a Plasmonic Nanocavity

Authors Chizhik AI, Sakhapov DI, Gregor I, Karedla N, Enderlein J Journal The journal of Physical Chemistry Letters Citation J Phys Chem Lett. 2025 Sep 11:9900-9905. Abstract Electric charges play a fundamental role in shaping the structure, function, and interactions of biomolecules, yet precisely measuring these charges at the single-molecule
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Prof. Dr. Emilie Macé, MBExC (Photo: private)

11.09.2025

Objects strengthen our inner compass

Researchers led by Prof. Dr. Emilie Macé, Head of the ‘Brain-wide Networks’ at the Department of Ophthalmology at the University Medical Center Göttingen (UMG), Co-Spokesperson for the Else Kröner Fresenius Center for Optogenetic Therapies at UMG, and Member of the Cluster of Excellence ‘Multiscale Bioimaging: From Molecular Machines to Networks
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11.09.2025

Charge-Dependent Fluorescence Lifetime Modulation in a Plasmonic Nanocavity

Authors Chizhik AI, Sakhapov DI, Gregor I, Karedla N, Enderlein J Journal The Journal of Physical Chemistry Letters Citation Phys Chem Lett. 2025 Sep 11:9900-9905. Abstract Electric charges play a fundamental role in shaping the structure, function, and interactions of biomolecules, yet precisely measuring these charges at the single-molecule level
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