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Calcium channels of synapses of sensory hair cells couple the sound stimulus to the excitation of the auditory nerve. Compared to the intact CaV1.3 channel (wildtyp, left), the genetically modified CaVAG variant, which is based on a minimal change in the blueprint of the CACNAD1 gene, causes activation of the synapses of sensory hair cells in response to very weak sound stimuli and thus leads to increased auditory nerve activity. The mouse model shows that the increased voltage sensitivity of the channel results in damage to the synapses due to overexcitation even at everyday sound levels. Figure: Karagulyan/Moser.

27.06.2025

Calcium channel in the ear: How a tiny mistake affects hearing

Researchers at the University Medical Center Göttingen (UMG) and the Göttingen Cluster of Excellence “Multiscale Bioimaging” (MBExC) have shown how a minimal change in a single ion channel increases the sensitivity of sensory cells in the inner ear. Even soft sounds, such as a whisper, are perceived more clearly, but
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Calcium channels of synapses of sensory hair cells couple the sound stimulus to the excitation of the auditory nerve. Compared to the intact CaV1.3 channel (wildtyp, left), the genetically modified CaVAG variant, which is based on a minimal change in the blueprint of the CACNAD1 gene, causes activation of the synapses of sensory hair cells in response to very weak sound stimuli and thus leads to increased auditory nerve activity. The mouse model shows that the increased voltage sensitivity of the channel results in damage to the synapses due to overexcitation even at everyday sound levels. Figure: Karagulyan/Moser.

27.06.2025

Calcium channel in the ear: How a tiny mistake affects hearing

Researchers at the University Medical Center Göttingen (UMG) and the Göttingen Cluster of Excellence “Multiscale Bioimaging” (MBExC) have shown how a minimal change in a single ion channel increases the sensitivity of sensory cells in the inner ear. Even soft sounds, such as a whisper, are perceived more clearly, but
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The organism used to investigate embryonic development: The image shows a top-down view of a fruit fly embryo. In the areas coloured red, cells synchronise their mechanical pulling force. Photo: A. R. Choudhury, M. Häring.

26.06.2025

Listening to each other

Like all complex organisms, every human originates from a single cell that multiplies through countless cell divisions. Thousands of cells coordinate, move and exert mechanical forces on each other as an embryo takes shape. Researchers at the Göttingen Campus Institute for Dynamics of Biological Networks (CIDBN), the Max Planck Institute
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The honorands signed their names in the Honorary Degrees Book at the Divinity School before moving to the Sheldonian Theatre. Image: John Cairns/University of Oxford.

25.06.2025

Erwin Neher receives honorary degree by the University of Oxford

On Wednesday 25 June, eight exceptional individuals whose achievements have made lasting contributions to the world were recognised at Oxford University’s Encaenia – an annual ceremony at which honorary degrees are conferred and the University’s benefactors are commemorated.   During the ceremony, degrees were awarded to Sir Mo Farah, MBExC
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Shanell (left) and Alma-Sophie (right) looking through a microscope. Photo: umg/valentin kloss

25.06.2025

DZKJ organises project days at XLAB

How does medical research work? How can children and young people actively participate? And why is their perspective so important for the further development of medicine? These questions were addressed during this year’s project days organised by the Department of Paediatrics and Adolescent Medicine at Göttingen University Medical Center Göttingen
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21.06.2025

Testosterone and atrial fibrillation: does the dose make the poison?

Authors Mason FE, Liutkute A, Voigt N Journal Cardiovascular Research Citation Cardiovasc Res. 2025 Jun 21:cvaf113. Abstract No abstract available. DOI 10.1093/cvr/cvaf113   Pubmed Link
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20.06.2025

The lincRNA Pantr1 is a FOXG1 target gene conferring site-specific chromatin binding of FOXG1

Authors Gather F, Rauleac T, Akol I, Arumugam G, Fullio CL, Müller T, Kleidonas D, Geiss-Friedlander R, Fischer A, Vlachos A, Backofen R, Vogel T Journal Nucleic Acids Research Citation Nucleic Acids Res. 2025 Jun 20;53(12):gkaf539. Abstract Derailed gene expression programs within the developing nervous system, encompassing both transcriptional and
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18.06.2025

Gating of hair cell Ca2+ channels governs the activity of cochlear neurons

Authors Karagulyan N, Thirumalai A, Michanski S, Qi Y, Fang Q, Wang H, Ortner NJ, Striessnig J, Strenzke N, Wichmann C, Hua Y, Moser T Journal Science Advances Citation Sci Adv. 2025 Jun 20;11(25):eadu7898. Abstract Our sense of hearing processes sound intensities spanning six orders of magnitude. In the ear,
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16.06.2025

Mitotic BLM functions are required to maintain genomic stability

Authors Hamann TE, Wieland A, Tirincsi A, Vukusic K, Mohseni F, Wardenaar R, Losito M, Goenenc II, Wollnik B, Foijer F, Tolic IM, Storchova Z, Raschle M Journal BioRxiv Citation bioRxiv 2025.06.16.659902. Abstract The BLM helicase is a critical genome maintenance protein involved in diverse cellular processes including DNA replication,
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12.06.2025

GEF25 symposium: Göttingen celebrates milestones in fluorescence microscopy

The first Göttingen Expansion Microscopy Forum (GEF25) will focus on the latest advances from a decade since the development of expansion microscopy, which is currently revolutionizing modern biological imaging. The focus will be on the latest developments that make this technique accessible and affordable to all laboratories and thus celebrated
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