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12.05.2025

Detection and inference of changes in high-dimensional linear regression with non-sparse structures

Authors Cho H, Kley T, Li H Journal Journal of the Royal Statistical Society, Series B Citation J R Stat Soc Series B: Stat Method. 2025. accepted manuscript. Abstract For data segmentation in high-dimensional linear regression settings, the regression parameters are often assumed to be sparse segment-wise, which enables many
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12.05.2025

Brain-derived synaptic vesicles have an intrinsic ability to sequester tubulin

Authors Mimoso T, Korobeinikov A, Stein A, Milovanovic D, Rizzoli SO, Köster S, Reshetniak S Journal BioRxiv Citation bioRxiv 2025.05.08.652815 Abstract The presence and function of microtubules within the synaptic bouton has long been under investigation. In recent years evidence has accumulated that connects the synaptic vesicle cluster to the
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In the cochlea of the inner ear, sound waves are detected in a frequency-specific manner and subsequently transmitted to the brain. Image @ Christian Vogl, Carlos Duque Afonso, Tobias Moser, Institute for Auditory Neuroscience, UMG.

11.05.2025

Illumination in the cochlea

Frankfurter Allgemeine Sonntagszeitung reports on hearing research in Göttingen: A new dimension of hearing for those who are deaf or extremely hard of hearing. A large research network in Göttingen around MBExC member Tobias Moser is developing a high-tech hearing aid that uses light and genetic engineering to enable hearing.
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11.05.2025

Blood-derived microRNA signatures associated with hippocampal structure and atrophy rate: Findings from the Rhineland Study

Authors Melas K, Talevi V, Aslam Imtiaz M, Krueger DM, Pena-Centeno T, Fischer A, Aziz NA, Breteler MMB Journal MedRxiv Citation medRxiv 2025.05.09.25327286 Abstract MicroRNAs have been linked to brain disorders, but their relations with hippocampal structure and atrophy remain unexplored. As the hippocampus is pivotal for cognition and dementia,
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09.05.2025

Lead as an Environmental Toxicant in Models of Synucleinopathies

Authors Shvachiy L, Amaro-Leal A, Machado F, Rocha I, Geraldes V, Outeiro TF Journal Chemosphere Citation Chemosphere. 2025 May 9;380:144477. Abstract Lead, a toxic heavy metal, is prevalent in various industrial applications, contributing to environmental contamination and significant health concerns. Lead affects various body systems, especially the brain, causing long-lasting
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08.05.2025

SEC24C deficiency causes trafficking and glycosylation abnormalities in an epileptic encephalopathy with cataracts and dyserythropoeisis

Authors Bögershausen N, Cavdarli B, Nagai TH, Milev MP, Wolff A, Mehranfar M, Schmidt J, Choudhary D, Gutiérrez-Gutiérrez Ó, Cyganek L, Saint-Dic D, Zibat A, Köhrer K, Wollenweber TE, Wieczorek D, Altmüller J, Borodina T, Kaçar D, Haliloğlu G, Li Y, Thiel C, Sacher M, Knapik EW, Yigit G, Wollnik
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Dr. Funsho Fakuade, UMG, first author of the study and member of the Hertha Sponer College of the Cluster of Excellence “Multiscale Bioimaging: From Molecular Machines to Networks of Excitable Cells” (MBExC). Photo: MBExC

07.05.2025

Oskar Lapp Research Award 2025 for cardiovascular research goes to Göttingen

Scientists from the ‘Molecular Pharmacology’ working group at the Institute of Pharmacology and Toxicology at the University Medical Center Göttingen (UMG) have been awarded this year’s Oskar Lapp Research Award. Dr. Funsho Fakuade, postdoctoral researcher, and medical students Dominik Hubricht and Vanessa Möller were presented with the award at the
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Magdalena Cöln and Ege Kingir from GRK 2824 give a lecture to students from the Otto Hahn Gymnasium in Göttingen. Photo: Christoph Matthes

06.05.2025

Insights into the connections between “Heart & Brain”

Within the framework of the Research Training Group (RTG) 2824 “Heart & Brain diseases: integrative research across organs”, MBExC member Tobias Brügmann and scientists from the RTG2824 had the exciting opportunity to show students of the Otto-Hahn-Gymnasium (OHG) in Göttingen the fascinating connections between the heart and brain. The session
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04.05.2025

SarcAsM: AI-based multiscale analysis of sarcomere organization and contractility in cardiomyocytes

Authors Haertter D, Hauke L, Driehorst T, Nishi K, Long J, Tiburcy M, Berecic B, Primeßnig A, Bao G, Cyganek L, Schmidt CF, Zimmermann WH Journal BioRxiv Citation bioRxiv 2025.04.29.650605. Abstract Cardiomyocyte function critically depends on sarcomere dynamics and their organization in myofibrils. To uncover how cardiomyocyte function emerges from
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02.05.2025

Filter-based models of suppression in retinal ganglion cells: Comparison and generalization across species and stimuli

Authors Shahidi N, Rozenblit F, Khani MH, Schreyer HM, Mietsch M, Protti DA, Gollisch T Journal PLoS Computational Biology Citation PLoS Comput Biol. 2025 May 2;21(5):e1013031. Abstract The dichotomy of excitation and suppression is one of the canonical mechanisms explaining the complexity of neural activity. Computational models of the interplay
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