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28.05.2025

Continuous dynamics of cooperation and competition in social foraging

Authors Lewen D, Ivanov V, Dehning J, Ruß J, Fischer A, Penke L, Schacht A, Gail A, Priesemann V, Kagan I Journal BioRxiv Citation bioRxiv 2025.05.28.655569. Abstract Real-life social interactions often unfold continuously and involve dynamic cooperation and competition, yet most studies rely on discrete games that do not capture
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Legend: 3D reconstruction of the myoferlin structure from cryo-EM datasets. Upon membrane-binding, a much more compact ring-like arrangement (right) of the various key domains (colored) is achieved compared to the lipid-free myoferlin protein (left). Credit: Cretu/mbexc

28.05.2025

Enigmatic ring carriers: Göttingen researchers uncover the structural secret of the ferline

Researchers from the Göttingen Cluster of Excellence Mutliscale Bioimaging (MBExC) have uncovered the 3D structure of the membrane proteins myoferlin and dysferlin using high-resolution cryo-electron microscopy. The findings enable new approaches for the development of targeted drugs for the treatment of diseases such as muscle atrophy, hearing disorders and certain
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Legend: 3D reconstruction of the myoferlin structure from cryo-EM datasets. Upon membrane-binding, a much more compact ring-like arrangement (right) of the various key domains (colored) is achieved compared to the lipid-free myoferlin protein (left). Credit: Cretu/mbexc

28.05.2025

Enigmatic ring carriers Göttingen researchers uncover the structural secret of the ferline

Researchers from the Göttingen Cluster of Excellence Mutliscale Bioimaging (MBExC) have uncovered the 3D structure of the membrane proteins myoferlin and dysferlin using high-resolution cryo-electron microscopy. The findings enable new approaches for the development of targeted drugs for the treatment of diseases such as muscle atrophy, hearing disorders and certain
Learn More
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28.05.2025

Myricetin-bound crystal structure of the SARS-CoV-2 helicase NSP13 facilitates the discovery of novel natural inhibitors

Authors Kloskowski P, Neumann P, Kumar P, Berndt A, Dobbelstein M, Ficner R Journal Acta Crystallographica Section D-Structural Biology Citation Acta Crystallogr D Struct Biol. 2025 Jun 1. Abstract The SARS-CoV-2 helicase NSP13 is a highly conserved and essential component of the viral replication machinery, making it a promising target
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28.05.2025

Structural insights into lipid membrane binding by human ferlins

Authors Cretu C, Chernev A, Szabo CZK, Pena V, Urlaub H, Moser T, Preobraschenski J Journal EMBO Journal Citation EMBO J. 2025 May 28. Abstract Ferlins are ancient membrane proteins with a unique architecture, and play central roles in crucial processes that involve Ca2+-dependent vesicle fusion. Despite their links to
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