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30.05.2025

Sarcomere analysis in human cardiomyocytes by computing radial frequency spectra

Authors Habeck M, Saleem N, Plota D, Cheruiyot C, Kohl T, Lehnart S, Jakobs S, Ebert A Journal BioRxiv Citation bioRxiv 2025.05.28.655290. Abstract In cardiomyocytes, the basic contractile unit are sarcomeres, which are organized in a regular manner facilitating their function. Here, we present a new computational approach to assess
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30.05.2025

Testing Paradox May Explain Increased Observed Prevalence of Bacterial STIs among MSM on HIV PrEP: A Modeling Study

Authors Müller L, Mallick P, Marín-Carballo AB, Dönges P, Kettlitz RJN, Klett-Tammen CJ, Kretzschmar M, Priesemann V, Contreras S Journal BioRxiv Citation arXiv:2505.24433. Abstract HIV pre-exposure Prophylaxis (PrEP) has become essential for global HIV control, but its implementation coincides with rising bacterial STI rates among men who have sex with
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28.05.2025

Continuous dynamics of cooperation and competition in social foraging

Authors Lewen D, Ivanov V, Dehning J, Ruß J, Fischer A, Penke L, Schacht A, Gail A, Priesemann V, Kagan I Journal BioRxiv Citation bioRxiv 2025.05.28.655569. Abstract Real-life social interactions often unfold continuously and involve dynamic cooperation and competition, yet most studies rely on discrete games that do not capture
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Legend: 3D reconstruction of the myoferlin structure from cryo-EM datasets. Upon membrane-binding, a much more compact ring-like arrangement (right) of the various key domains (colored) is achieved compared to the lipid-free myoferlin protein (left). Credit: Cretu/mbexc

28.05.2025

Enigmatic ring carriers: Göttingen researchers uncover the structural secret of the ferline

Researchers from the Göttingen Cluster of Excellence Mutliscale Bioimaging (MBExC) have uncovered the 3D structure of the membrane proteins myoferlin and dysferlin using high-resolution cryo-electron microscopy. The findings enable new approaches for the development of targeted drugs for the treatment of diseases such as muscle atrophy, hearing disorders and certain
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Legend: 3D reconstruction of the myoferlin structure from cryo-EM datasets. Upon membrane-binding, a much more compact ring-like arrangement (right) of the various key domains (colored) is achieved compared to the lipid-free myoferlin protein (left). Credit: Cretu/mbexc

28.05.2025

Enigmatic ring carriers Göttingen researchers uncover the structural secret of the ferline

Researchers from the Göttingen Cluster of Excellence Mutliscale Bioimaging (MBExC) have uncovered the 3D structure of the membrane proteins myoferlin and dysferlin using high-resolution cryo-electron microscopy. The findings enable new approaches for the development of targeted drugs for the treatment of diseases such as muscle atrophy, hearing disorders and certain
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28.05.2025

Myricetin-bound crystal structure of the SARS-CoV-2 helicase NSP13 facilitates the discovery of novel natural inhibitors

Authors Kloskowski P, Neumann P, Kumar P, Berndt A, Dobbelstein M, Ficner R Journal Acta Crystallographica Section D-Structural Biology Citation Acta Crystallogr D Struct Biol. 2025 Jun 1. Abstract The SARS-CoV-2 helicase NSP13 is a highly conserved and essential component of the viral replication machinery, making it a promising target
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28.05.2025

Structural insights into lipid membrane binding by human ferlins

Authors Cretu C, Chernev A, Szabo CZK, Pena V, Urlaub H, Moser T, Preobraschenski J Journal EMBO Journal Citation EMBO J. 2025 May 28. Abstract Ferlins are ancient membrane proteins with a unique architecture, and play central roles in crucial processes that involve Ca2+-dependent vesicle fusion. Despite their links to
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27.05.2025

Success rates of simulated multi-pulse defibrillation protocols are sensitive to application timing with individual, protocol-specific optimal timings

Authors Aron M, Luther S, Parlitz U Journal Frontiers in Network Physiology Citation Front Netw Physiol. 2025 May 27;5:1572834. Abstract Ventricular fibrillation is a lethal condition where the heartbeat becomes too disorganised to maintain proper circulation. It is treated with defibrillation, which applies an electric shock in an attempt to
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27.05.2025

Toward elucidating the mechanism of cochlear stimulation by infrared light

Authors Moser T, Roos L Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2025 Jun 3;122(22):e2507582122. Abstract No abstract available. DOI 10.1073/pnas.2507582122   Pubmed Link
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Multiscale Bioimaging at Work. Photo & cover credits: Klein und Neumann, Iserlohn

22.05.2025

Out of the Excellence Strategy competition

The University of Göttingen has been turned down for the Excellence Strategy of the German national and state governments: funding for the Multiscale Bioimaging (MBExC) Cluster of Excellence will not be extended. This was announced today by the Excellence Commission, the joint committee of the German Research Foundation (DFG) and
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