2024

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Dr. Steffen Sahl (left) and Prof. Dr. Stefan Hell at a MINFLUX microscope. © Irene Böttcher-Gajewski / Max Planck Institute for Multidisciplinary Sciences

10.10.2024

Intra-molecular distances in biomolecules measured optically with Ångström precision

A team led by physicists Steffen Sahl and Stefan Hell at the Max Planck Institute (MPI) for Multidisciplinary Sciences in Göttingen and the MPI for Medical Research in Heidelberg has succeeded in measuring distances within biomolecules using a light microscope, down to 1 nanometer and with Ångström precision. The intra-molecular
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Dr. Steffen Sahl (left) and Prof. Dr. Stefan Hell at a MINFLUX microscope. © Irene Böttcher-Gajewski / Max Planck Institute for Multidisciplinary Sciences

10.10.2024

Intra-molecular distances in biomolecules measured optically with Ångström precision

A team led by physicists Steffen Sahl and Stefan Hell at the Max Planck Institute (MPI) for Multidisciplinary Sciences in Göttingen and the MPI for Medical Research in Heidelberg has succeeded in measuring distances within biomolecules using a light microscope, down to 1 nanometer and with Ångström precision. The intra-molecular
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10.10.2024

Direct optical measuerement of intramolecular distances with angstrom precision

Authors Sahl SJ, Matthias J, Inamdar K, Weber M, Khan TA, Brüser C, Jakobs S, Becker S, Griesinger C, Broichhagen J, Hell SW Journal Science Citation Science. 2024 Oct 11;386(6718):180-187. Abstract Optical investigations of nanometer distances between proteins, their subunits, or other biomolecules have been the exclusive prerogative of Förster
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10.10.2024

NanoPlex: a universal strategy for fluorescence microscopy multiplexing using nanobodies with erasable signals

Authors Mougios N, Cotroneo ER, Imse N, Setzke J, Rizzoli S, Simeth NA, Tsukanov R, Opazo F Journal Nature Communications Citation Nat Commun. 2024 Oct 10;15(1):8771. Abstract Fluorescence microscopy has long been a transformative technique in biological sciences. Nevertheless, most implementations are limited to a few targets, which have been
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The inventors (from left), group leader Dr. Ali H. Shaib and Professor Dr. Silvio O. Rizzoli, director of the Department for Neuro- and Sensory Physiology at the University Medical Center Göttingen (UMG). Photo: A. Shaib.

09.10.2024

ONE microscopy: from molecule to 3D structure with conventional microscopy

Researchers at the University Medical Center Göttingen (UMG) have developed a new method that makes it possible for the first time to image the three-dimensional shape of proteins with a conventional microscope. Combined with artificial intelligence, One-step Nanoscale Expansion (ONE) microscopy enables the detection of structural changes in damaged or
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The inventors (from left), group leader Dr. Ali H. Shaib and Professor Dr. Silvio O. Rizzoli, director of the Department for Neuro- and Sensory Physiology at the University Medical Center Göttingen (UMG). Photo: A. Shaib.

09.10.2024

ONE microscopy: from molecule to 3D structure with conventional microscopy

Researchers at the University Medical Center Göttingen (UMG) have developed a new method that makes it possible for the first time to image the three-dimensional shape of proteins with a conventional microscope. Combined with artificial intelligence, One-step Nanoscale Expansion (ONE) microscopy enables the detection of structural changes in damaged or
Learn More
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09.10.2024

One-step nanoscale expansion microscopy reveals individual protein shapes

Authors Shaib AH, Chouaib AA, Chowdhury R, Altendorf J, Mihaylov D, Zhang C, Krah D, Imani V, Spencer RKW, Georgiev SV, Mougios N, Monga M, Reshetniak S, Mimoso T, Chen H, Fatehbasharzad P, Crzan D, Saal KA, Alawieh MM, Alawar N, Eilts J, Kang J, Soleimani A, Müller M, Pape
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08.10.2024

“Heart & Brain – understanding together” – Our exhibition has been extended!

Exhibition at the Forum Wissen Göttingen extended until Oct 20, 2024   Due to the enormous demand – more than 17.000 people have seen the exhibition so far – it will be extended until 20 October 2024.   How does a “patch” for the heart work? Can we hear with
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08.10.2024

Cardiac arrhythmias: the growing role of autoantibodies in diagnosis and treatment

Authors Fakuade FE, Grune J, Voigt N Journal European Heart Journal Citation Eur Heart J. 2024 Oct 8:ehae648. Abstract No abstract available. DOI 10.1093/eurheartj/ehae648   Pubmed Link
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05.10.2024

The synaptic vesicle cluster as a controller of pre- and postsynaptic structure and function

Authors Reshetniak S, Bogaciu CA, Bonn S, Brose N, Cooper BH, D’Este E, Fauth M, Fernández-Busnadiego R, Fiosins M, Fischer A, Georgiev SV, Jakobs S, Klumpp S, Köster S, Lange F, Lipstein N, Macarrón-Palacios V, Milovanovic D, Moser T, Müller M, Opazo F, Outeiro TF, Pape C, Priesemann V, Rehling
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