2024

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10.06.2024

Lysosomal signalling pathways influence heart rhythm, and regulate atrial function

Authors Capel RA, Akerman E, Rog-Zielinska E, Winbo A, Aston D, Mu-u-min RBA, Read MJ, Bose SJ, Swietach P, Wang J, Corbett AD, Koschinski A, Montgomery JM, Falter F, Calamaio S, Melgari D, Prevostini R, Rivolta I, Ayagama T, Jenkin I, Simon JN, Fakuade FE, Pronto J, Sharma P, Song
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07.06.2024

Mechanism of human PINK1 activation at the TOM complex in a reconstituted system

Authors Raimi OG, Ojha H, Ehses K, Dederer V, Lange SM, Rivera CP, Deegan TD, Chen Y, Wightman M, Toth R, Labib KPM, Mathea S, Ranson N, Fernández-Busnadiego R, Muqit MMK Journal Science Advances Citation Sci Adv. 2024 Jun 7;10(23):eadn7191. Abstract Loss-of-function mutations in PTEN-induced kinase 1 (PINK1) are a
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07.06.2024

Establishing synthetic ribbon-type active zones in a heterologous expression system

Authors Kapoor R, Schwenzer N, Dresbach T, Lehnart S, Moser T Journal eLife Citation eLife 13:RP98254. Abstract Encoding of several sensory modalities into neural signals is mediated by ribbon synapses. The synaptic ribbon tethers synaptic vesicles at the presynaptic active zone (AZ) and might act as a super-scaffold organizing AZ
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06.06.2024

Open Problem: Active Representation Learning

Authors Milosevic N, Müller G, Huisken J, Scherf N Journal Arxiv Citation arXiv:2406.03845. Abstract In this work, we introduce the concept of Active Representation Learning, a novel class of problems that intertwines exploration and representation learning within partially observable environments. We extend ideas from Active Simultaneous Localization and Mapping (active
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04.06.2024

Effective exosomes reduction in hypercholesterinemic patients suffering from cardiovascular diseases by lipoprotein apheresis: Exosomes apheresis

Authors Schröder S, Epple R, Fischer A, Schettler VJJ Journal Therapeutic Apheresis and Dialysis Citation Ther Apher Dial. 2024 Jun 4. Abstract Introduction: Extracellular vesicles (EVs) have been identified as playing a role in atherosclerosis. Methods: A group of 37 hypercholesterolemic patients with atherosclerotic cardiovascular diseases (ASCVD) and 9 patients
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03.06.2024

The COMBO window: A chronic cranial implant for multiscale circuit interrogation in mice

Authors Edelman BJ, Siegenthaler D, Wanken P, Jenkins B, Schmid B, Ressle A, Gogolla N, Frank T, Macé E Journal Plos Biology Citation PLOS Biology 22(6): e3002664. Abstract Neuroscientists studying the neural correlates of mouse behavior often lack access to the brain-wide activity patterns elicited during a specific task of
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03.06.2024

Catching up but still miles behind — a patient registry for otoferlin

Authors Vona B, Wollnik B, Strenzke N, Moser T Journal Experimental & Molecular Medicine Citation Exp Mol Med (2024). Abstract No abstract available. DOI 10.1038/s12276-024-01247-6   Pubmed Link
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01.06.2024

Analyzing cross-talk between superimposed signals: Vector norm dependent hidden Markov models and applications to ion channels

Authors Vanegas LJ, Eltzner B, Rudolf D, Dura M, Lehnart SE, Munk A Journal The Annals of Applied Statistics Citation Ann. Appl. Stat. 18(2): 1445-1470. Abstract We propose and investigate a hidden Markov model (HMM) for the analysis of dependent, aggregated, superimposed two-state signal recordings. A major motivation for this
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01.06.2024

Through the Haze: Unveiling the Link Between Smoking and Atrial Fibrillation

Authors Mason FE, Voigt N Journal American Journal of Physiology. Heart and Circulatory Physiology Citation Am J Physiol Heart Circ Physiol. 2024 Jun 1;326(6):H1489-H1490. Abstract No abstract available. DOI 10.1152/ajpheart.00286.2024   Pubmed Link
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01.06.2024

Characterizing intracellular mechanics via optical tweezers-based microrheology

Authors Vos BE, Muenker TM, Betz T Journal Current Opinion in Cell Biology Citation Curr Opin Cell Biol. 2024 Jun 1;88:102374. Abstract Intracellular organization is a highly regulated homeostatic state maintained to ensure eukaryotic cells’ correct and efficient functioning. Thanks to decades of research, vast knowledge of the proteins involved
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