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18.10.2024

Mechanism of polyadenylation-independent RNA polymerase II termination

Authors Rengachari S, Hainthaler T, Oberthuer C, Lidschreiber M, Cramer P Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol (2024). Abstract The mechanisms underlying the initiation and elongation of RNA polymerase II (Pol II) transcription are well-studied, whereas termination remains poorly understood. Here we analyze the mechanism
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16.10.2024

Addressing SARS-CoV-2 viroporins with antiarrhythmic drugs

Authors Bloothooft M, Voigt N, de Boer TP Journal Europace Citation Europace. 2024 Oct 3;26(10):euae254. Abstract No abstract available. DOI 10.1093/europace/euae254   Pubmed Link
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16.10.2024

Ex vivo imaging reveals the spatiotemporal control of ovulation

Authors Thomas C, Marx TL, Penir SM, Schuh M Journal Nature Cell Biology Citation Nat Cell Biol. 2024 Oct 16. Abstract During ovulation, an egg is released from an ovarian follicle, ready for fertilization. Ovulation occurs inside the body, impeding direct studies of its progression. Therefore, the exact mechanisms that
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14.10.2024

Lead as a toxic environmental toxicant in models of synucleinopathies

Authors Shvachiy L, Amaro-Leal A, Machado F, Rocha I, Geraldes V, Outeiro TF Journal BioRxiv Citation bioRxiv 2024.10.10.617554. Abstract Lead, a toxic heavy metal, is prevalent in various industrial applications, contributing to environmental contamination and significant health concerns. Lead affects various body systems, especially the brain, causing long-lasting cognitive and
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Dr. Steffen Sahl (left) and Prof. Dr. Stefan Hell at a MINFLUX microscope. © Irene Böttcher-Gajewski / Max Planck Institute for Multidisciplinary Sciences

10.10.2024

Intra-molecular distances in biomolecules measured optically with Ångström precision

A team led by physicists Steffen Sahl and Stefan Hell at the Max Planck Institute (MPI) for Multidisciplinary Sciences in Göttingen and the MPI for Medical Research in Heidelberg has succeeded in measuring distances within biomolecules using a light microscope, down to 1 nanometer and with Ångström precision. The intra-molecular
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Dr. Steffen Sahl (left) and Prof. Dr. Stefan Hell at a MINFLUX microscope. © Irene Böttcher-Gajewski / Max Planck Institute for Multidisciplinary Sciences

10.10.2024

Intra-molecular distances in biomolecules measured optically with Ångström precision

A team led by physicists Steffen Sahl and Stefan Hell at the Max Planck Institute (MPI) for Multidisciplinary Sciences in Göttingen and the MPI for Medical Research in Heidelberg has succeeded in measuring distances within biomolecules using a light microscope, down to 1 nanometer and with Ångström precision. The intra-molecular
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10.10.2024

Direct optical measuerement of intramolecular distances with angstrom precision

Authors Sahl SJ, Matthias J, Inamdar K, Weber M, Khan TA, Brüser C, Jakobs S, Becker S, Griesinger C, Broichhagen J, Hell SW Journal Science Citation Science. 2024 Oct 11;386(6718):180-187. Abstract Optical investigations of nanometer distances between proteins, their subunits, or other biomolecules have been the exclusive prerogative of Förster
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10.10.2024

NanoPlex: a universal strategy for fluorescence microscopy multiplexing using nanobodies with erasable signals

Authors Mougios N, Cotroneo ER, Imse N, Setzke J, Rizzoli S, Simeth NA, Tsukanov R, Opazo F Journal Nature Communications Citation Nat Commun. 2024 Oct 10;15(1):8771. Abstract Fluorescence microscopy has long been a transformative technique in biological sciences. Nevertheless, most implementations are limited to a few targets, which have been
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The inventors (from left), group leader Dr. Ali H. Shaib and Professor Dr. Silvio O. Rizzoli, director of the Department for Neuro- and Sensory Physiology at the University Medical Center Göttingen (UMG). Photo: A. Shaib.

09.10.2024

ONE microscopy: from molecule to 3D structure with conventional microscopy

Researchers at the University Medical Center Göttingen (UMG) have developed a new method that makes it possible for the first time to image the three-dimensional shape of proteins with a conventional microscope. Combined with artificial intelligence, One-step Nanoscale Expansion (ONE) microscopy enables the detection of structural changes in damaged or
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The inventors (from left), group leader Dr. Ali H. Shaib and Professor Dr. Silvio O. Rizzoli, director of the Department for Neuro- and Sensory Physiology at the University Medical Center Göttingen (UMG). Photo: A. Shaib.

09.10.2024

ONE microscopy: from molecule to 3D structure with conventional microscopy

Researchers at the University Medical Center Göttingen (UMG) have developed a new method that makes it possible for the first time to image the three-dimensional shape of proteins with a conventional microscope. Combined with artificial intelligence, One-step Nanoscale Expansion (ONE) microscopy enables the detection of structural changes in damaged or
Learn More
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