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11.07.2024

A roadmap for ribosome assembly in human mitochondria

Authors Lavdovskaia E, Hanitsch E, Linden A, Pašen M, Challa V, Horokhovskyi Y, Roetschke HP, Nadler F, Welp L, Steube E, Heinrichs M, Mai MM, Urlaub H, Liepe J, Richter-Dennerlein R Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol. 2024 Jul 11. Abstract Mitochondria contain dedicated ribosomes
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11.07.2024

Early mutational signatures and transmissibility of SARS-CoV-2 Gamma and Lambda variants in Chile

Authors Oróstica KY, Mohr SB, Dehning J, Bauer S, Medina-Ortiz D, Iftekhar EN, Mujica K, Covarrubias PC, Ulloa S, Castillo AE, Daza-Sánchez A, Verdugo RA, Fernández J, Olivera-Nappa Á, Priesemann V, Contreras S Journal Scientific Reports Citation Sci Rep. 2024 Jul 11;14(1):16000. Abstract Genomic surveillance (GS) programmes were crucial in
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11.07.2024

Neurofilament Light Chain Serum Levels Mirror Age and Disability in Secondary Progressive Multiple Sclerosis: A Cross-Sectional Study

Authors Husseini L, Jung J, Boess N, Kruse N, Nessler S, Stadelmann C, Metz I, Haupts M, Weber MS Journal Neurology: Neuroimmunology & Neuroinflammation Citation Neurol Neuroimmunol Neuroinflamm. 2024 Sep;11(5):e200279. Abstract Objectives: To assess neurofilament light chain serum (sNfL) levels in patients with secondary progressive multiple sclerosis (SP-MS). Methods: Using
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© Melina Schuh / Max Planck Institute for Multidisciplinary Sciences

10.07.2024

Egg cell maintenance: Long-lived proteins may be essential

Female mammals – including humans – are born with all of their egg cells. Of a woman’s one to two million egg cells, about 400 mature before menopause and can be fertilized. Some egg cells therefore survive for several decades – and need to remain functional over this long time.
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© Melina Schuh / Max Planck Institute for Multidisciplinary Sciences

10.07.2024

Egg cell maintenance: Long-lived proteins may be essential

Female mammals – including humans – are born with all of their egg cells. Of a woman’s one to two million egg cells, about 400 mature before menopause and can be fertilized. Some egg cells therefore survive for several decades – and need to remain functional over this long time.
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08.07.2024

Polycystin-1 loss of function increases susceptibility to atrial fibrillation through impaired DNA damage response

Authors Hendrickson T, Giese A, Fiedler M, Perez W, Reyes-Sanchez E, Reyes-Lozano M, Wang S, Venegas-Zamora L, Provasek V, El-Essawi A, Breitenbach I, Fakuade F, Kutschka I, Schiattarella GG, Voigt N, Valderrábano M, Altamirano F Journal BioRxiv Citation bioRxiv 2024.07.08.602618. Abstract Background: The increasing prevalence of atrial fibrillation (AF) and
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05.07.2024

Synthesis and Semi-Synthesis of Alpha-Synuclein: Insight into the Chemical Complexity of Synucleinopathies

Authors Gatzemeier LM, Meyer F, Outeiro TF Journal ChemBioChem Citation Chembiochem. 2024 Jul 5:e202400253. Abstract The chemical rules governing protein folding have intrigued generations of researchers for decades. With the advent of artificial intelligence (AI), prediction of protein structure has improved tremendously. However, there is still a level of analysis
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02.07.2024

Glycation of alpha-synuclein enhances aggregation and neuroinflammatory responses

Authors Vasili E, Konig A, Al-Azzani M, Bosbach C, Gatzemeier LM, Chegao A, Miranda HV, Erskine D, Outeiro T Journal BioRxiv Citation bioRxiv 2024.06.27.600956. Abstract The risk of developing Parkinson’s disease (PD) is elevated in people with type 2 diabetes, but the precise molecular pathways underlying this connection are still
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02.07.2024

Interfering with aggregated α-synuclein in advanced melanoma leads to a major upregulation of MHC class II proteins

Authors Fokken C, Silbern I, Shomroni O, Pan KT, Ryazanov S, Leonov A, Winkler N, Urlaub H, Griesinger C, Becker D Journal Melanoma Research Citation Melanoma Res. 2024 Jul 2. Abstract Melanoma is the most serious and deadly form of skin cancer and with progression to advanced melanoma, the intrinsically
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MBExC special exhibition "Heart & Brain - Understanding Together" at Forum Wissen

01.07.2024

Heart & Brain – understanding together

Special exhibition at the Forum Wissen   How does a “patch” for the heart work? Can we hear with light? And how can insights from basic research be used to help diagnose and treat diseases? The “Heart & Brain – understanding together” exhibition examines these and related questions between these
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