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A view into the cell using an optical laser trap: it localizes microscopic particles in order to draw conclusions about their random trembling movement. A new approach developed by the Göttingen researchers makes it possible to deduce from these movements how hard, soft or liquid the inside of the cell is. Photo: Till Moritz Münker

31.07.2024

“Laser view” into the avocado: new method reveals cell interior

Research team at the University of Göttingen develops method for recognizing cell properties   Checking whether an avocado is hard or soft by looking at it? This would require recognizing how the plant cells behave behind the skin. The same applies to all other cells on our planet: Despite more
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31.07.2024

Accessing activity and viscoelastic properties of artificial and living systems from passive measurement

Authors Muenker TM, Knotz G, Krüger M, Betz T Journal Nature Materials Citation Nat Mater. 2024 Jul 31. Abstract Living systems are complex dynamic entities that operate far from thermodynamic equilibrium. Their active, non-equilibrium behaviour requires energy to drive cellular organization and dynamics. Unfortunately, most statistical mechanics approaches are not
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28.07.2024

Helical superstructures between amyloid and collagen VI in heart-derived fibrils from a patient with Light Chain Amyloidosis

Authors Schulte T, Chaves-Sanjuan A, Speranzini V, Sicking K, Milazzo M, Mazzini G, Rognoni P, Caminito S, Milani P, Marabelli C, Corbelli A, Diomede L, Fiordaliso F, Anastasia L, Pappone C, Merlini G, Bolognesi M, Nuvolone M, Fernández-Busnadiego R, Palladini G, Ricagno S Journal Nature Communications Citation Nat Commun. 2024
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24.07.2024

Microlens arrays for multichannel laser-to-waveguide coupling

Authors Kunze K, Gossler C, Peters V, Keppeler D, Moser T, Schwarz UT Journal Applied Optics Citation Appl. Opt. 63, 5876-5885 (2024). Abstract An optical multichannel coupling system for coupling laser arrays to waveguide arrays is developed. Based on a microlens array, the system enables coupling of nine individual optical
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22.07.2024

Transient Non-local Interactions Dominate the Dynamics of Measles Virus NTAIL

Authors Otteson L, Nagy G, Kunkel J, Kodis G, Zheng W, Bignon C, Longhi S, Grubmüller H, Vaiana AC, Vaiana SM Journal BioRxiv Citation bioRxiv 2024.07.22.604679. Abstract The RNA genome of measles virus is encapsidated by the nucleoprotein within a helical nucleocapsid that serves as template for both transcription and
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21.07.2024

Distributional limits of graph cuts on discretized grids

Authors Suchan L, Li H, Munk A Journal Arxiv Citation arXiv:2407.15297. Abstract Graph cuts are among the most prominent tools for clustering and classification analysis. While intensively studied from geometric and algorithmic perspectives, graph cut-based statistical inference still remains elusive to a certain extent. Distributional limits are fundamental in understanding
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19.07.2024

Peripheral whole blood microRNA expression in relation to vascular function: a population-based study

Authors Talevi V, Melas K, Pehlivan G, Imtiaz MA, Krüger DM, Centeno TP, Aziz NA, Fischer A, Breteler MMB Journal Journal of Translational Medicine Citation J Transl Med. 2024 Jul 19;22(1):670. Abstract Background: As key regulators of gene expression, microRNAs affect many cardiovascular mechanisms and have been associated with several
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18.07.2024

FASTKD5 processes mitochondrial pre-mRNAs at non-canonical cleavage sites

Authors Antonicka H, Weraarpachai W, Vučković A, Hillen HS, Shoubridge EA Journal BioRxiv Citation bioRxiv 2024.07.18.603998. Abstract The regulation of mammalian mitochondrial gene expression is largely post-transcriptional and the first step in translating the 13 polypeptides encoded in mtDNA is endonucleolytic cleavage of the primary polycistronic transcripts. As the rRNAs
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16.07.2024

Dysferlin Enables Tubular Membrane Proliferation in Cardiac Hypertrophy

Authors Paulke NJ, Fleischhacker C, Wegener JB, Riedemann GC, Cretu C, Mushtaq M, Zaremba N, Möbius W, Zühlke Y, Wedemeyer J, Liebmann L, Gorshkova AA, Kownatzki-Danger D, Wagner E, Kohl T, Wichmann C, Jahn O, Urlaub H, Toischer K, Hasenfuß G, Moser T, Preobraschenski J, Lenz C, Rog-Zielinska EA, Lehnart
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13.07.2024

Mutation-induced LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome

Authors Busley AV, Gutiérrez-Gutiérrez Ó, Hammer E, Koitka F, Mirzaiebadizi A, Steinegger M, Pape C, Böhmer L, Schroeder H, Kleinsorge M, Engler M, Cirstea IC, Gremer L, Willbold D, Altmüller J, Marbach F, Hasenfuss G, Zimmermann WH, Ahmadian MR, Wollnik B, Cyganek L Journal Cell Reports Citation Cell Rep. 2024
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