March

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29.03.2024

Generation of a pluripotent stem cell line (UMGi270-A) and a corresponding CRISPR/Cas9 modified isogenic control (UMGi270-A-1) from a patient with sudden onset dilated cardiomyopathy harboring a FLNC p.R2187P mutation

Authors Maurer W, Rebs S, Köhne S, Eberl H, Wollnik B, Zibat A, Streckfuss-Bömeke K Journal Stem Cell Research Citation Stem Cell Res. 2024 Mar 29;77:103409. Abstract Filamin C (FLNC) is a highly important actin crosslinker and multi-adaptor protein in striated skeletal and cardiac muscle. Mutations have been linked to
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29.03.2024

Label-free quantification of imaging features in the extracellular matrix of left and right-sided colon cancer tissues

Authors Arora B, Kulkarni A, Markus MA, Ströbel P, Bohnenberger H, Alves F, Ramos-Gomes F Journal Scientific Reports Citation Sci Rep. 2024 Mar 29;14(1):7510. Abstract The molecular pathogenesis of colorectal cancer is known to differ between the right and left side of the colon. Several previous studies have focussed on
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27.03.2024

Dynamic Gain Decomposition Reveals Functional Effects of Dendrites, Ion Channels, and Input Statistics in Population Coding

Authors Zhang C, Revah O, Wolf F, Neef A Journal Journal of Neuroscience Citation J Neurosci. 2024 Mar 27;44(13):e0799232023. Abstract Modern, high-density neuronal recordings reveal at ever higher precision how information is represented by neural populations. Still, we lack the tools to understand these processes bottom-up, emerging from the biophysical
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27.03.2024

Chemical synthesis of site-selective advanced glycation end products in α-synuclein and its fragments

Authors Bosbach C, Gatzemeier LM, Bloch von Blottnitz KI, König A, Diederichsen U, Steinem C, Outeiro TF Journal Organic & Biomolecular Chemistry Citation Org Biomol Chem. 2024 Mar 27;22(13):2670-2676. Abstract Advanced glycation end products (AGEs) arise from the Maillard reaction between dicarbonyls and proteins, nucleic acids, or specific lipids. Notably,
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27.03.2024

Formation of memory assemblies through the DNA-sensing TLR9 pathway

Authors Jovasevic V, Wood EM, Cicvaric A, Zhang H, Petrovic Z, Carboncino A, Parker KK, Bassett TE, Moltesen M, Yamawaki N, Login H, Kalucka J, Sananbenesi F, Zhang X, Fischer A, Radulovic J   Journal Nature   Citation Nature. 2024 Apr;628(8006):145-153.   Abstract As hippocampal neurons respond to diverse types
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25.03.2024

Regulation of Zbp1 by miR-99b-5p in microglia controls the development of schizophrenia-like symptoms in mice

Authors Kaurani L, Islam MR, Heilbronner U, Krüger DM, Zhou J, Methi A, Strauss J, Pradhan R, Schröder S, Burkhardt S, Schuetz AL, Pena T, Erlebach L, Bühler A, Budde M, Senner F, Kohshour MO, Schulte EC, Schmauß M, Reininghaus EZ, Juckel G, Kronenberg-Versteeg D, Delalle I, Odoardi F, Flügel
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25.03.2024

Gene therapy for deafness: are we there now?

Authors Moser T, Chen H, Kusch K, Behr R, Vona B   Journal EMBO Molecular Medicine   Citation EMBO Mol Med. 2024 Mar 25.   Abstract No abstract available.   DOI 10.1038/s44321-024-00058-6   Pubmed Link
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In the research laboratory: (from left to right) Prof. Dr. Metin Tolan, President of the University of Göttingen, Falko Mohrs, Minister for Science and Culture of Lower Saxony, Prof. Dr. Claudia Steinem, Deputy Spokesperson of the MBExC and Professor at the Faculty of Chemistry at the University of Göttingen, Prof. Dr Wolfgang Brück, Spokesperson of the Board of Directors and Director of Research and Teaching at the University Medical Center Göttingen (UMG), and Prof. Dr. Emilie Macé, Professor of Dynamics of Excitable Cell Networks at the Center for Biostructural Imaging of Neurodegeneration (BIN). Photo: umg/spförtner

22.03.2024

Minister of Science Falko Mohrs visits Göttingen Cluster of Excellence

Falko Mohrs, Minister of Science and Culture of Lower Saxony, visited the researchers of the Göttingen Cluster of Excellence “Multiscale Bioimaging: From Molecular Machines to Networks of Excitable Cells” (MBExC) on Friday, 22 March 2024. The occasion was the continuation application to be submitted by MBExC in August to apply
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In the research laboratory: (from left to right) Prof. Dr. Metin Tolan, President of the University of Göttingen, Falko Mohrs, Minister for Science and Culture of Lower Saxony, Prof. Dr. Claudia Steinem, Deputy Spokesperson of the MBExC and Professor at the Faculty of Chemistry at the University of Göttingen, Prof. Dr Wolfgang Brück, Spokesperson of the Board of Directors and Director of Research and Teaching at the University Medical Center Göttingen (UMG), and Prof. Dr. Emilie Macé, Professor of Dynamics of Excitable Cell Networks at the Center for Biostructural Imaging of Neurodegeneration (BIN). Photo: umg/spförtner

22.03.2024

Minister of Science Falko Mohrs visits Göttingen Cluster of Excellence

Falko Mohrs, Minister of Science and Culture of Lower Saxony, visited the researchers of the Göttingen Cluster of Excellence “Multiscale Bioimaging: From Molecular Machines to Networks of Excitable Cells” (MBExC) on Friday, 22 March 2024. The occasion was the continuation application to be submitted by MBExC in August to apply
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22.03.2024

Gender-Specific Effects on the Cardiorespiratory System and Neurotoxicity of Intermittent and Permanent Low-Level Lead Exposures

Authors Shvachiy L, Amaro-Leal Â, Machado F, Rocha I, Outeiro TF, Geraldes V Journal Biomedicines Citation Biomedicines. 2024 Mar 22;12(4):711. Abstract Lead exposure is a significant health concern, ranking among the top 10 most harmful substances for humans. There are no safe levels of lead exposure, and it affects multiple
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