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Mitochondrial network in a cell. Source: UMG/MPI/nh

19.01.2024

Energy supply in human cells is subject to quality control

Researchers at the University Medical Center Göttingen (UMG) and members of the MBExC have discovered a new quality control mechanism that regulates the energy production in human cells. This process takes place in mitochondria, the power plants of the cell. Malfunctions of mitochondria lead to serious diseases of the nerves,
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17.01.2024

CryoRhodopsins: a comprehensive characterization of a new clade of microbial rhodopsins from cold environments

Authors Lamm GHU, Marin E, Schellbach AV, Stetsenko A, Alekseev A, Bourenkov G, Borshchevskiy V, Asido M, Agthe M, Engilberge S, Rose SL, Caramello N, Royant A, Schneider TR, Bateman A, Mager T, Moser T, Wachtveitl J, Guskov A, Kovalev K Journal BioRxiv Citation bioRxiv 2024.01.15.575777. Abstract Microbial rhodopsins are
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17.01.2024

Metal-induced energy transfer (MIET) Imaging of cell surface engineering with multivalent DNA nanobrushes

Authors Wang DX, Liu B, Han GM, Kong DM, Enderlein J, Chen T Journal ACS Nano Citation ACS Nano. 2024 Jan 17. Abstract The spacing between cells has a significant impact on cell–cell interactions, which are critical to the fate and function of both individual cells and multicellular organisms. However,
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13.01.2024

A single-cell transcriptomic analysis of the mouse hippocampus after voluntary exercise

Authors Methi A, Islam MR, Kaurani L, Sakib MS, Krueger DM, Pena T, Burkhardt S, Liebetanz D, Fischer A Journal Molecular Neurobiology Citation Mol Neurobiol. 2024 Jan 13. Abstract Exercise has been recognized as a beneficial factor for cognitive health, particularly in relation to the hippocampus, a vital brain region
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10.01.2024

Folate receptor α deficiency – Myelin-sensitive MRI as a reliable biomarker to monitor the efficacy and long-term outcome of a new therapeutic approach

Authors Dreha-Kulaczewski S, Sahoo P, Preusse M, Gkalimani I, Dechent P, Helms G, Hofer S, Steinfeld R, Gärtner J Journal Journal of Inherited Metabolic Disease Citation J Inherit Metab Dis. 2024 Mar;47(2):387-403. Abstract Cerebral folate transport deficiency, caused by a genetic defect in folate receptor α, is a devastating neurometabolic
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09.01.2024

Substitution of Met-38 to Ile in γ-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid

Authors Aubrey LD, Ninkina N, Ulamec SM, Abramycheva NY, Vasili E, Devine OM, Wilkinson M, Mackinnon E, Limorenko G, Walko M, Muwanga S, Amadio L, Peters OM, Illarioshkin SN, Outeiro TF, Ranson NA, Brockwell DJ, Buchman VL, Radford SE Journal Proceedings of the National Academy of Sciences of the United
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08.01.2024

Uncovering potential diagnostic and pathophysiological roles of α-synuclein and DJ-1 in melanoma

Authors Quesnel A, Martin LD, Tarzi C, Lenis VP, Coles N, Islam M, Angione C, Outeiro TF, Khundakar AA, Filippou PS Journal Cancer Medicine Citation Cancer Med. 2024 Jan 8. Abstract Background Melanoma, the most lethal skin cancer type, occurs more frequently in Parkinson’s disease (PD), and PD is more
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08.01.2024

Characterization of transient and progressive pulmonary fibrosis by spatially correlated phase contrast microCT, classical histopathology and atomic force microscopy

Authors D’Amico L, Svetlove A, Longo E, Meyer R, Senigagliesi B, Saccomano G, Nolte P, Wagner WL, Wielpütz MO, Leitz DHW, Duerr J, Mall MA, Casalis L, Köster S, Alves F, Tromba G, Dullin C Journal Computers in Biology and Medicine Citation Comput Biol Med. 2024 Jan 8;169:107947. Abstract Pulmonary
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05.01.2024

Noninvasive analysis of contractility during identical maturations revealed two phenotypes in ventricular but not in atrial iPSC-CM

Authors Rapöhn M, Cyganek L, Voigt N, Hasenfuß G, Lehnart SE, Wegener JW Journal American Journal of Physiology. Heart and Circulatory Physiology Citation Am J Physiol Heart Circ Physiol. 2024 Jan 5. Abstract Patient-derived induced pluripotent stem cells (iPSC) can be differentiated into atrial and ventricular cardiomyocytes to allow for
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04.01.2024

Image restoration of degraded time-lapse microscopy data mediated by near-infrared imaging

Authors Gritti N, Power RM, Graves A, Huisken J Journal Nature Methods Citation Nat Methods (2024). Abstract Time-lapse fluorescence microscopy is key to unraveling biological development and function; however, living systems, by their nature, permit only limited interrogation and contain untapped information that can only be captured by more invasive
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