2023

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02.02.2023

The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system

Authors Saha I, Yuste-Checa P, Da Silva Padilha M, Guo Q, Körner R, Holthusen H, Trinkaus VA, Dudanova I, Fernández-Busnadiego R, Baumeister W, Sanders DW, Gautam S, Diamond MI, Hartl FU, Hipp MS Journal Nature Communications Citation Nat Commun. 2023 Feb 2;14(1):560. Abstract Amyloid-like aggregates of the microtubule-associated protein Tau
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01.02.2023

miR-101a-3p Impairs Synaptic Plasticity and Contributes to Synucleinopathy

Authors Xylaki M, Paiva I, Al-Azzani M, Gerhardt E, Jain G, Islam MR, Vasili E, Wassouf Z, Schulze-Hentrich JM, Fischer A, Outeiro TF Journal Journal of Parkinson’s Disease Citation J Parkinsons Dis. 2023 Feb 1. Abstract Background: Synucleinopathies are disorders characterized by the abnormal accumulation of α-synuclein (aSyn). Synaptic compromise
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Prof. Dr. Rubén Fernández-Busnadiego, University Medical Center (Photo: MBExC) Figure: 3D rendering of a cryo-electron tomogram of a peripheral nerve. (Reproduced from https://www.biorxiv.org/content/10.1101/2021.04.14.437159)

31.01.2023

European funding for Rubén Fernández Busnadiego

Expert in cryo-electron microscopy at the University Medical Center Göttingen receives Consolidator Grant of the European Research Council to investigate the membrane architecture of nerve cells and its pathological alterations in axonopathies. (mbexc/umg) Prof. Dr. Rubén Fernández Busnadiego from the Institute for Neuropathology at the University Medical Center Göttingen (UMG)
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Prof. Dr. Rubén Fernández-Busnadiego, University Medical Center (Photo: MBExC) Figure: 3D rendering of a cryo-electron tomogram of a peripheral nerve. (Reproduced from https://www.biorxiv.org/content/10.1101/2021.04.14.437159)

31.01.2023

European funding for Rubén Fernández Busnadiego

Rubén Fernández Busnadiego, expert in cryo-electron microscopy at the University Medical Center Göttingen (UMG) and member of the MBExC received a Consolidator Grant of the European Research Council (ERC). The ERC supports his research project ”In situ structural basis of human axonopathies“ (“cryoNERVE“) over five years with a total of
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27.01.2023

Cholesterol-Induced Nanoscale Variations in the Thickness of Phospholipid Membranes

Authors Chen T, Ghosh A, Enderlein J Journal Nano Letters Citation Nano Lett. 2023 Jan 27. Abstract Graphene-induced energy transfer (GIET) is a recently developed fluorescence-spectroscopic technique that achieves subnanometric optical localization of fluorophores along the optical axis of a microscope. GIET is based on the near-field energy transfer from
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23.01.2023

Towards Unbiased Fluorophore Counting in Superresolution Fluorescence Microscopy

Authors Laitenberger O, Aspelmeier T, Staudt T, Geisler C, Munk A, Egner A Journal Nanomaterials Citation Nanomaterials 2023, 13(3), 459. Abstract With the advent of fluorescence superresolution microscopy, nano-sized structures can be imaged with a previously unprecedented accuracy. Therefore, it is rapidly gaining importance as an analytical tool in the
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Artistic representation showing how an image is created using the newly developed method. Two colours – green and magenta – are emitted by fluorescing atoms in the sample (left) due to X-Ray excitation. The grey round object represents an optic casting a shadow on the detector. The algorithm then produces an actual image with two colours – the intensity of which represents the density of the fluorescing atoms within the sample. Photo: Markus Osterhoff

23.01.2023

Colour images from the shadow of a sample

A research team at the University of Göttingen has developed a new method to produce X-ray images in colour. In the past, the only way to determine the chemical composition of a sample and the position of its components using X-ray fluorescence analysis was to focus the X-rays and scan
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23.01.2023

Patient perspectives on the need for improved hearing rehabilitation: A qualitative survey study of German cochlear implant users

Authors Hunniford V, Kühler R, Wolf B, Keppeler D, Strenzke N, Moser T Journal Frontiers in Neuroscience Citation Front Neurosci. 2023 Jan 23;17:1105562. Abstract Background The electrical cochlear implant (eCI) partially restores hearing in individuals affected by profound hearing impairment (HI) or deafness. However, the limited resolution of sound frequency
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21.01.2023

Single-cell transcriptomics reveal extracellular vesicles secretion with a cardiomyocyte proteostasis signature during pathological remodeling

Authors Schoger E, Bleckwedel F, Germena G, Rocha C, Tucholla P, Sobitov I, Möbius W, Sitte M, Lenz C, Samak M, Hinkel R, Varga ZV, Giricz Z, Salinas G, Gross JC, Zelarayán LC Journal Communications Biology Citation Commun Biol. 2023 Jan 21;6(1):79. Abstract Aberrant Wnt activation has been reported in failing
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21.01.2023

Simulation of Complex Biomolecular Systems: The Ribosome Challenge

Authors Bock LV, Gabrielli S, Kolá MH, Grubmüller H   Journal Annual Review of Biophysics   Citation Annu. Rev. Biophys. 2023. 52:15.1–15.30.   Abstract Large biomolecular systems are at the heart of many essential cellular processes. The dynamics and energetics of an increasing number of these systems are being studied
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