2023

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06.03.2023

Intermittent Lead Exposure Induces Behavioral and Cardiovascular Alterations Associated with Neuroinflammation

Authors Shvachiy L, Amaro-Leal Â, Outeiro TF, Rocha I, Geraldes V   Journal Cells   Citation Cells. 2023 Mar 6;12(5):818.   Abstract The nervous system is the primary target for lead exposure and the developing brain appears to be especially susceptible, namely the hippocampus. The mechanisms of lead neurotoxicity remain
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Dr. Antoine Huet, MBExC Junior Fellow, Institute for Auditory Neuroscience, UMG. Photo: mbexc.

03.03.2023

In the control room for hearing with light

Optical cochlear implants promise to improve the restoration of hearing in hearing loss and deafness. A Göttingen team of hearing researchers around Antoine Huet have now defined for the first time the biologically plausible range of stimulation parameters for the use of the optical cochlea implant in humans. Published in
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Dr. Antoine Huet, MBExC Junior Fellow, Institute for Auditory Neuroscience, UMG. Photo: mbexc.

03.03.2023

In the control room for hearing with light

Optical cochlear implants promise to improve the restoration of hearing in hearing loss and deafness. A Göttingen team of hearing researchers around Antoine Huet have now defined for the first time the biologically plausible range of stimulation parameters for the use of the optical cochlea implant in humans. Published in
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02.03.2023

A small-angle X-ray scattering study of red blood cells in continuous flow

Authors Burchert JP, Graceffa R, Saldanha O, Burghammer M, Köster S Journal Journal of Synchrotron Radiation Citation J Synchrotron Radiat. 2023 May 1. Abstract Owing to their large penetration depth and high resolution, X-rays are ideally suited to study structures and structural changes within intact biological cells. For this reason,
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28.02.2023

In vitro reconstitution of chromatin domains

Authors Quililan K, Oberbeckmann E, Cramer P, Oudelaar AM   Journal BioRxiv   Citation bioRxiv 2023.02.27.530214.   Abstract The spatial organization of the genome modulates nuclear processes, including transcription, replication, and DNA repair1,2. Eukaryotic genomes are organized into distinct 3D chromatin domains3. However, the molecular mechanisms that drive the formation
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28.02.2023

The multifaceted mitochondrial OXA insertase

Authors Homberg B, Rehling P, Cruz-Zaragoza LD Journal Trends in Cell Biology Citation Trends Cell Biol. 2023 Feb 28:S0962-8924(23)00020-X. Abstract Most mitochondrial proteins are synthesized in the cytosol and transported into mitochondria by protein translocases. Yet, mitochondria contain their own genome and gene expression system, which generates proteins that are
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Prof. Dr. Tobias Moser, Director of the Institute for Auditory Neuroscience, University Medical Center Göttingen and spokesperson of the CRC 1690. Photo: mbexc/spförtner

23.02.2023

ERC Proof of Concept Grant for Tobias Moser

Prof. Dr. Tobias Moser, MBExC spokesperson and Director of the Institute for Auditory Neuroscience at the University Medical Center Göttingen, received an ERC Proof of Concept Grant for his project on „Waveguide-based Cochlear Implants for Optogenetic Stimulation“ (OptoWave). The grant about 150.000 euros enables researchers to bridge the gap between
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Prof. Dr. med. Tobias Moser, Director of the Institute for Auditory Neuroscience Göttingen, UMG. Photo: MBExC / spförtner

23.02.2023

ERC Proof of Concept Grant for Tobias Moser

Auditory neuroscientist of the University Medical Center Göttingen receives additional funding by the European Research Council. His project “OptoWave” concentrates on optimizing the optical cochlear implant for the application in hearing impaired people. (mbexc/umg) Tobias Moser, MD, Director of the Institute for Auditory Neuroscience at the University Medical Center Göttingen
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22.02.2023

Phosphodiesterase 8 governs cAMP/PKA-dependent reduction of L-type calcium current in human atrial fibrillation: a novel arrhythmogenic mechanism

Authors Grammatika Pavlidou N, Dobrev S, Beneke K, Reinhardt F, Pecha S, Jacquet E, Abu-Taha IH, Schmidt C, Voigt N, Kamler M, Schnabel RB, Baczkó I, Garnier A, Reichenspurner H, Nikolaev VO, Dobrev D, Molina CE Journal European Heart Journal Citation Eur Heart J. 2023 Feb 22:ehad086. Abstract Aims: Atrial
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22.02.2023

Conserved reduction of m6A RNA modifications during aging and neurodegeneration is linked to changes in synaptic transcripts

Authors Castro-Hernández R, Berulava T, Metelova M, Epple R, Peña Centeno T, Sakib MS, Burkhart S, Ninov M, Bohnsack KE, Bohnsack MT, Delalle I, Fischer A Journal Proceedings of the National Academy of Sciences Citation Proc Natl Acad Sci U S A. 2023 Feb 28;120(9):e2204933120. Abstract N6-methyladenosine (m6A) regulates mRNA
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