2022

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15.02.2022

Statistical spatial analysis for cryo-electron tomography

Authors Martinez-Sanchez A, Baumeister W, Lučić V Journal Computer Methods and Programs in Biomedicine Citation Comput Methods Programs Biomed. 2022 Feb 15;218:106693.  Abstract Cryo-electron tomography (cryo-ET) is uniquely suited to precisely localize macromolecular complexes in situ, that is in a close-to-native state within their cellular compartments, in three-dimensions at high resolution.
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11.02.2022

Role of Mitochondrial Nucleic Acid Sensing Pathways in Health and Patho-Physiology

Authors Chowdhury A, Witte S, Aich A Journal Frontiers in Cell and Developmental Biology Citation Front Cell Dev Biol. 2022 Feb 11;10:796066.  Abstract Mitochondria, in symbiosis with the host cell, carry out a wide variety of functions from generating energy, regulating the metabolic processes, cell death to inflammation. The most prominent
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meiosis of a human oocyte

During meiosis, the spindle (green) of a human oocyte halves the chromosome set by segregating the chromosome pairs (magenta). © Chun So / Max Planck Institute for Multidisciplinary Sciences

11.02.2022

A missing ‘motor’ causes our eggs to fail

Human eggs often contain the wrong number of chromosomes, leading to miscarriages and infertility. A research team led by MBExC member Melina Schuh at the Max Planck Institute (MPI) for Multidisciplinary Sciences has discovered that human eggs are missing an important protein, which acts as a molecular motor. This motor
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11.02.2022

Allosteric control of Ubp6 and the proteasome via a bidirectional switch

Authors Hung KYS, Klumpe S, Eisele MR, Elsasser S, Tian G, Sun S, Moroco JA, Cheng TC, Joshi T, Seibel T, Van Dalen D, Feng XH, Lu Y, Ovaa H, Engen JR, Lee BH, Rudack T, Sakata E, Finley D Journal Nature Communications Citation Nat Commun. 2022 Feb 11;13(1):838. Abstract
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11.02.2022

Mechanism of spindle pole organization and instability in human oocytes

Authors So C, Menelaou K, Uraji J, Harasimov K, Steyer AM, Seres KB, Bucevičius J, Lukinavičius G, Möbius W, Sibold C, Tandler-Schneider A, Eckel H, Moltrecht R, Blayney M, Elder K, Schuh M Journal Science Citation Science. 2022 Feb 11;375(6581):eabj3944. Abstract Human oocytes are prone to assembling meiotic spindles with
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10.02.2022

Rethinking opsins

Authors Feuda R, Menon AK, Göpfert MC Journal Molecular Biology and Evolution Citation Mol Biol Evol. 2022 Feb 10:msac033. Abstract Opsins, the protein moieties of animal visual photo-pigments, have emerged as moonlighting proteins with diverse, light-dependent and -independent physiological functions. This raises the need to revise some basic assumptions concerning
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First and senior authors of the publication (from left): Dr. Stefan Nessler (Insitute of Neuropathology), Prof. Dr. Jutta Gärtner, Dr. Matthias Kettwig and Dr. Katharina Ternka (all from the Dep. of Paediatrics and Youth Medicine), University Medical Center Göttingen. Photo: umg.

07.02.2022

How does too much interferon damage the brain of unborn children?

Researchers at the University Medical Center Göttingen (UMG), including MBExC members André Fischer, Jutta Gärtner, Peter Rehling and Christine Stadelmann-Nessler, have created the first animal model that can be used to study the damaging mechanisms of excessive interferon release on the brain. The results were published in the scientific open-access
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Prof. Dr. Dr. h.c. mult. Stefan W. Hell; © Irene Böttcher-Gajewski / Max Planck Institute for Multidisciplinary Sciences

01.02.2022

Stefan Hell receives Werner-von-Siemens-Ring 2022

This year, the Werner von Siemens Ring Foundation is honoring Max Planck researcher and MBExC member Stefan Hell for pioneering achievements in the technical sciences. The physicist and Nobel laureate succeeded in observing living cells at the molecular level using a new type of super-resolution microscopy. In addition to Hell,
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31.01.2022

Single-cell transcription profiles in Bloom syndrome patients link BLM deficiency with altered condensin complex expression signatures

Authors Gönenc II, Wolff A, Schmidt J, Zibat A, Müller C, Cyganek L, Argyriou L, Räschle M, Yigit G, Wollnik B Journal Human Molecular Genetics Citation Hum Mol Genet. 2022 Jan 31:ddab373. Abstract Bloom syndrome (BS) is an autosomal recessive disease clinically characterized by primary microcephaly, growth deficiency, immunodeficiency, and
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27.01.2022

Structural basis for safe and efficient energy conversion in a respiratory supercomplex

Authors Kao WC, Ortmann de Percin Northumberland C, Cheng TC, Ortiz J, Durand A, von Loeffelholz O, Schilling O, Biniossek ML, Klaholz BP, Hunte C Journal Nature Communications Citation Nat Commun. 2022 Jan 27;13(1):545. Abstract Proton-translocating respiratory complexes assemble into supercomplexes that are proposed to increase the efficiency of energy
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