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31.10.2022

Peptide Conjugated Dihydroazulene/Vinylheptafulvene Photoswitches in Aqueous Environment

Authors Corbet BP, Schlüter JM, Cotroneo ER, Crespi S, Simeth NA Journal European Journal of Organic Chemistry Citation Eur. J. Org. Chem. 2022, e202201140 Abstract Light-responsive molecules have seen a major advance in modulating biological functions in recent years. Especially photoswitches are highly attractive building blocks due to the reversible
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27.10.2022

Human mtRF1 terminates COX1 translation and its ablation induces mitochondrial ribosome-associated quality control

Authors Nadler F, Lavdovskaia E, Krempler A, Cruz-Zaragoza LD, Dennerlein S, Richter-Dennerlein R Journal Nature Communications Citation Nat Commun. 2022 Oct 27;13(1):6406. Abstract Translation termination requires release factors that read a STOP codon in the decoding center and subsequently facilitate the hydrolysis of the nascent peptide chain from the peptidyl
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Prof. Dr. Viola Priesemann. Photo: MPI-DS / Peter Heller

25.10.2022

Award for interdisciplinary research

The Arthur Burkhard Foundation for the Advancement of Science gives its award in 2022 to MBExC member Viola Priesemann from the Max Planck Institute for Dynamics and Self-Organization (MPI-DS) and the University of Göttingen. The award, endowed with 10,000 euros, is presented annually to outstanding scientists who have made outstanding
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25.10.2022

Cochlear Hair Cell Innervation is Dependent on a Modulatory Function of Semaphorin-3A

Authors Cantu-Guerra HL, Papazian MR, Gorsky AL, Alekos NS, Caccavano A, Karagulyan N, Neef J, Vicini S, Moser T, Coate TM Journal Developmental Dynamics Citation Dev Dyn. 2022 Oct 25. Abstract Background: Proper connectivity between type I spiral ganglion neurons (SGNs) and inner hair cells (IHCs) in the cochlea is
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22.10.2022

Lost in promiscuity? An evolutionary and biochemical evaluation of HSD10 function in cardiolipin metabolism

Authors Wohlfarter Y, Eidelpes R, Yu RD, Sailer S, Koch J, Karall D, Scholl-Bürgi S, Amberger A, Hillen HS, Zschocke J, Keller MA Journal Cellular and Molecular Life Sciences Citation Cell Mol Life Sci. 2022 Oct 22;79(11):562. Abstract Multifunctional proteins are challenging as it can be difficult to confirm pathomechanisms
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21.10.2022

Mammalian oocytes store mRNAs in a mitochondria-associated membraneless compartment

Authors Cheng S, Altmeppen G, So C, Welp LM, Penir S, Ruhwedel T, Menelaou K, Harasimov K, Stützer A, Blayney M, Elder K, Möbius W, Urlaub H, Schuh M Journal Science Citation Oct 21;378(6617):eabq4835. Abstract Full-grown oocytes are transcriptionally silent and must stably maintain the messenger RNAs (mRNAs) needed for
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18.10.2022

Deep, deep learning with BART

Authors Blumenthal M, Luo G, Schilling M, Holme HCM, Uecker M Journal Magnetic Resonance in Medicine Citation Magn Reson Med. 2022 Oct 18. Abstract Purpose: To develop a deep-learning-based image reconstruction framework for reproducible research in MRI. Methods: The BART toolbox offers a rich set of implementations of calibration and reconstruction algorithms for
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18.10.2022

Engineered skeletal muscle recapitulates human muscle development, regeneration and dystrophy

Authors Shahriyari M, Islam MR, Sakib SM, Rinn M, Rika A, Krüger D, Kaurani L, Gisa V, Winterhoff M, Anandakumar H, Shomroni O, Schmidt M, Salinas G, Unger A, Linke WA, Zschüntzsch J, Schmidt J, Bassel-Duby R, Olson EN, Fischer A, Zimmermann WH, Tiburcy M Journal Journal of Cachexia, Sarcopenia
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Reconstruction of a mitochondrion based on electron microscopic data (Source: P. Ilgen/Jacobs Lab)

14.10.2022

Focus on Mitochondrial Nanostructure: DFG FOR 2848 “Nanoscale Architecture and Heterogeneity of the Mitochondrial Inner Membrane” funded for another 3 years

The DFG FOR (“Research Unit”) 2848 “Nanoscale Architecture and Heterogeneity of the Mitochondrial Inner Membrane” coordinated by MBExC member Stefan Jakobs (Clinic for Neurology, UMG/MPI for Multidisciplinary Sciences) is funded for another 3 years with 1.3 Million Euros. Since 2019, the scientists have been working on questions concerning the nanostructure
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11.10.2022

Homozygous loss-of-function variants in FILIP1 cause autosomal recessive arthrogryposis multiplex congenita

Authors Schnabel F, Schuler E, Al-Maawali A, Chaurasia A, Syrbe S, Al-Kindi A, Bhavani GS, Shukla A, Altmüller J, Nürnberg P, Banka S, Girisha KM, Li Y, Wollnik B, Yigit G Journal Human Genetics Citation Human Genetics. preprint under review. 2022 Abstract Arthrogryposis multiplex congenita forms a broad group of
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