Sections through the three-dimensional reconstruction volume (upper left, grey) around a pulmonary alveolus with hyaline membrane (lower left, yellow). On the right, the images are superimposed. In the centre is the air bubble (alveolus). The electron density is represented by different shades of grey. On the inside of the air bubble is a layer of proteins and dead cell residues, the "hyaline membrane". This deposit, which can be represented in its three-dimensional structure for the first time by the new method, reduces the gas exchange and leads to respiratory distress.
Photo: Tim Salditt, Marina Eckermann

New insights into lung tissue in Covid-19 disease

Physicists at the University of Göttingen and the Cluster of Excellence “Multiscale Bioimaging” (MBExC), together with pathologists and lung specialists at the Medical University of Hannover, have developed a three-dimensional imaging technique that enables high resolution and three-dimensional representation of damaged lung tissue following severe Covid-19. Using a special X-ray microscopy technique, they were able to image changes caused by the coronavirus in the structure of alveoli (the tiny air sacs in the lung) and the vasculature.

The results of the study were published in the research journal eLife.

Link to the press release