SIM Talk and Workshop

We want to announce an exciting talk on a new Microscopy Structured Illumination Microscope (MI-SIM) on Friday, 14 June 2024 at 2:00 p.m. in the seminar room of the Center for Biostructural Imaging of Neurodegeneration (BIN), Von-Siebold-Straße 3a, 37075 Göttingen:

“Revolutionizing Live-Cell Imaging: Enhanced Resolution, Accelerated Speed, and Integrated Intelligence with Advanced SIM Technology” by Dr. Ke Du, Product Manager at CSR Biotech

Abstract:
Structured Illumination Microscopy (SIM) represents a robust super-resolution fluorescence imaging technique ideally suited for dynamic live-cell applications. Utilizing structured light for illumination, SIM facilitates the acquisition of fine structural details without necessitating specialized labeling techniques. Recent advancements in optical components and algorithmic approaches have significantly extended SIM’s capabilities, overcoming previous limitations. The integration of Hessian-SIM and Sparse-SIM methodologies has ushered in enhanced performance metrics across various parameters, coupled with intelligent imaging technologies. The advanced optical design and computational methods enable our MI-SIM to resolve structures as small as 60 nm in live cells, specifically observing the dynamic ring structures of nuclear pores. Furthermore, it achieves imaging speeds of up to 564 frames per second, which is an order of magnitude faster than conventional SIM techniques. For prolonged super-resolution imaging, our system minimizes photobleaching, allowing for continuous data acquisition over periods extending up to three days. Additionally, our MI-SIM supports real-time super-resolution recording and intelligent XYZ tracking to optimize imaging efficiency.

Host: Stefan Jakobs, UMG & MPI-NAT

The speaker, Dr. Ke Du from CSR Biotech, is a SIM expert with extensive experience in developing advanced super-resolution microscopies.
We currently have the chance to test and use this microscope in the lab and attendees will have the opportunity to book a live demo to examine their own samples with this microscope in the next two weeks. Please register at ed.gdwg@bal-sbokaj.

Please find here the PDFs of the announcement of the workshop and the talk