MBExC Lecture

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february, 2023

202323feb1:00 PM2:00 PMMBExC LectureMolecular Imaging of the Heart-Brain Axis to Guide Repair after Ischemic Damage1:00 PM - 2:00 PM UMG, HS 01/02, Robert-Koch-Str. 40, 37075 GöttingenSpeaker:Professor James T. Thackeray, PhD, Hannover Medical School

Event Details

Professor James T. Thackeray, PhD from the Translational Cardiovascular Molecular Imaging (TCMI), Department of Nuclear Medicine, Hannover Medical School will talk about “Molecular Imaging of the Heart-Brain Axis to Guide Repair after Ischemic Damage”

The heart and brain comprise an interdependent symbiotic relationship. But what happens when a component of this battery is compromised, for example by ischemic damage? Does injury to one organ anticipate or instigate reciprocal harm to other organs, particularly those as tightly connected as the heart and brain? Clinical and experimental evidence suggests that myocardial ischemia imparts a higher risk of dementia, including Alzheimer’s disease. Cerebral stroke is associated with higher incidence of myocardial infarction and heart failure progression. Despite the observed evidence, the biologic mechanisms underlying this interconnection are poorly characterized. Part of this gap in knowledge derives from the technical challenges of assessing aberrations in multiple organs at the tissue or molecular level. Noninvasive strategies that enable simultaneous assessment of systems biology are appealing, and whole body molecular imaging using positron emission tomography to assess dysfunction provides a unique perspective on the evolution of disease. In this lecture, we will address the reciprocal damage incurred by distant organs after focal ischemic injury, and explore how molecular imaging methods provide new insights into inter-organ communication through the immune system after ischemic injury.

Hosts: Prof. Dr. Tobias Moser and Bettina Wolf, PhD

Location: Lecture hall 01/02, University Medical Center Göttingen, Robert-Koch-Str. 40

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