MBExC Lecture

Prof. Dr. Hans-Dieter Arndt from the Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University Jena will give a talk on “From Natural Products Synthesis to Tool Compounds for Chemical Biology” during the MBExC Lecture in cooperation with the OC Colloquium on January 9th, 2024 at 17:15 at the lecture hall MN28 (room no. E1.112) at the Faculty of Chemistry, Tammannstr. 4, 37077 Göttingen.

Link to the lecture hall
 
Abstract:
Bioactive natural products inspire the advancement of chemical synthesis as well as research into the identification and validation of biological targets. This will be initially illustrated by the first total synthesis of the peculiar copper transport factor methanobactin. Then, investigations toward the synthesis and function of the algael growth and differentiation factor (-)-thallusin will be presented. Finally, the long term development of F-actin targeting tool compounds will be described, culminating in advanced F-actin photoswitches (“neo-optojasp”) and novel, non-toxic reagents (“NEO-actin”) for high-resolution F-actin imaging by fluorescence microscopy in vitro and in vivo.
 
Host: Jun.-Prof. Dr. Nadja A. Simeth, University of Göttingen