august, 2023
Event Details
Luis Fernando Santana, Ph.D., Professor and Chair of the Department of Physiology and Membrane Biology from the UC Davis School of Medicine, CA will talk about “Random walks: How ion channel clusters form in the sarcolemma of muscle cells” during the MBExC online Lecture on August 31st, 2023 at 3 pm.
Abstract
In this seminar, Dr. Santana will provide an overview of recent work examining the mechanisms and functional implications of ion channel clustering in the sarcolemma of cardiac and arterial smooth muscle in health and disease. He will describe a model for stochastic self-assembly of protein clustering and how it provides a new framework to methodically study ion channel trafficking. Dr. Santana will present data suggesting that clustering enables cooperative gating of voltage-gated calcium channels and that this is critical for excitation-contraction coupling in smooth and cardiac muscle. Furthermore, ion channel clustering influences excitation-transcription coupling by modulating intracellular signaling pathways, leading to specific transcription factor activation and initiation of gene expression programs.
Host: Prof. Dr. Stephan Lehnart, UMG
Please find the poster of the announcement here: 
