Chair: Prof. Dr. Tobias Moser Hinrich Staecker, MD, PhD, from the Departments of Otolaryngology, Head and Neck Surgery,
Chair: Prof. Dr. Tobias Moser
Hinrich Staecker, MD, PhD, from the Departments of Otolaryngology, Head and Neck Surgery, University of Kansas Medical Center, Kansas City will talk about “Challenges in translating gene therapy for inner ear disorders” during the upcoming CRC889 Sensory Lecture.
Our increased understanding of the underlying causes of many hearing disorders has led to the development of molecular therapeutics to address a variety of disorders. The CGF166 (atoh1) human clinical trial has enhanced our ability to model and understand the delivery of viral vectors to the human inner ear and serves as a model for understanding the translation of a range of molecular therapeutics into clinical trials. Key issues emerging from this study are identification of appropriate models for preclinical testing development of improved testing to aid in patient selection and optimization of delivery approaches. There has also been a leap forward in the development of synthetic vectors that can target the inner ear. The next generation of translational studies will address a broader range of inner ear applications including genetic hearing loss, protection of the inner ear and modification of cellular phenotype.
Further information on the CRC 889 website: www.sfb889.uni-goettingen.de
Click here for the poster of the talk.