Molecular Neurobiology

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13.01.2024

A single-cell transcriptomic analysis of the mouse hippocampus after voluntary exercise

Authors Methi A, Islam MR, Kaurani L, Sakib MS, Krueger DM, Pena T, Burkhardt S, Liebetanz D, Fischer A Journal Molecular Neurobiology Citation Mol Neurobiol. 2024 Jan 13. Abstract Exercise has been recognized as a beneficial factor for cognitive health, particularly in relation to the hippocampus, a vital brain region
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04.01.2022

Endogenous Levels of Alpha-Synuclein Modulate Seeding and Aggregation in Cultured Cells

Authors Vasili E, Dominguez-Meijide A, Flores-León M, Al-Azzani M, Kanellidi A, Melki R, Stefanis L, Outeiro TF Journal Molecular Neurobiology Citation Mol Neurobiol. 2022 Jan 4. Abstract Parkinson’s disease is a progressive neurodegenerative disorder characterized by the accumulation of misfolded alpha-synuclein in intraneuronal inclusions known as Lewy bodies and Lewy
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10.02.2021

The Coding And Small-Non-Coding Hippocampal Synaptic RNAome

Authors Epple R, Krüger D, Berulava T, Brehm G, Ninov M, Islam R, Köster S, Fischer A Journal Molecular Neurobiology Citation Mol Neurobiol. 2021 Feb 10. Abstract Neurons are highly compartmentalized cells that depend on local protein synthesis. Messenger RNAs (mRNAs) have thus been detected in neuronal dendrites, and more
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07.01.2021

Alpha-Synuclein Antibody Characterization: Why Semantics Matters

Authors Outeiro TF Journal Molecular Neurobiology Citation Mol Neurobiol. 2021 Jan 7. Abstract In protein aggregation disorders, we assume that, during the process of protein aggregation, different types of aggregated species (oligomers, protofibrils, fibrils, etc.) are formed, some of which can be toxic to cells/tissues/organs. Recent evidence from numerous studies
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