2023

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Prof. Dr. Patrick Cramer © Irene Böttcher-Gajewski / Max Planck Institute for Multidisciplinary Sciences

06.05.2023

Patrick Cramer erhält Röntgenplakette

MBExC-Mitglied Prof. Dr. Patrick Cramer, MPI für Multidisziplinäre Naturwissenschaften, hat die Röntgenplakette 2023 für seine bahnbrechenden Forschungen zur Entschlüsselung des Gentranskriptions-Mechanismus unter Verwendung von Röntgenmethoden erhalten. Die Röntgen-Plakette wird vom Oberbürgermeister oder der Oberbürgermeisterin der Stadt Remscheid an Persönlichkeiten verliehen, die sich im weitesten Sinne um den Fortschritt und die
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Prof. Dr. Timo Betz (Photo: UMG/SPförtner)

05.05.2023

Timo Betz erhält ERC Proof of Concept Grant

Biophysiker und MBExC-Mitglied Prof. Dr. Timo Betz von der Universität Göttingen hat einen Proof of Concept (PoC) Grant des European Research Council (ERC) erhalten. Der ERC fördert damit sein Projekt „TissMec“, mit dem Betz und sein Team ein 3D-Screening-System zur Kultivierung von Gewebe und zur automatischen Stimulation und Quantifizierung seiner
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02.05.2023

The genetic spectrum of congenital ocular motor apraxia type Cogan: an observational study, continued

Authors Schröder S, Yigit G, Li Y, Altmüller J, Büttel HM, Fiedler B, Kretzschmar C, Nürnberg P, Seeger J, Serpieri V, Valente EM, Wollnik B, Boltshauser E, Brockmann K Journal Orphanet Journal of Rare Diseases Citation Orphanet J Rare Dis. 2023 May 2;18(1):101. Abstract Background: The term congenital ocular motor
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02.05.2023

Three-dimensional analysis of human pancreatic cancer specimens by phase-contrast based X-ray tomography – the next dimension of diagnosis

Authors Pinkert-Leetsch D, Frohn J, Ströbel P, Alves F, Salditt T, Missbach-Guentner J Journal Cancer Imaging Citation Cancer Imaging. 2023 May 2;23(1):43. Abstract Background: The worldwide increase of pancreatic ductal adenocarcinoma (PDAC), which still has one of the lowest survival rates, requires novel imaging tools to improve early detection and
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01.05.2023

Decoding and Recoding of mRNA Sequences by the Ribosome

Authors Rodnina MV Journal Annual Reviews of Biophysics Citation Annu. Rev. Biophys. 2023. 52:161–82. Abstract Faithful translation of messenger RNA (mRNA) into protein is essential to maintain protein homeostasis in the cell. Spontaneous translation errors are very rare due to stringent selection of cognate aminoacyl transfer RNAs (tRNAs) and the
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29.04.2023

Generation of a genetically-modified induced pluripotent stem cell line harboring a Noonan syndrome-associated gene variant MRAS p.G23V

Authors Busley AV, Cyganek L Journal Stem Cell Research Citation Stem Cell Res. 2023 Jun;69:103108. Abstract Patients harboring causative gene variants in RAS GTPase MRAS develop Noonan syndrome and early-onset hypertrophic cardiomyopathy. Here, we describe the generation of a human iPSC line harboring the Noonan syndrome-associated MRAS p.G23V variant by
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Das Gesamtkunstwerk "The art of Science". Foto: umg/spförtner

28.04.2023

„The Art of Science“ – Hirnforschung meets Street Art

50 Bilder aus der neurowissenschaftlichen Grundlagenforschung wurden von Mitarbeitenden der Abteilung Experimentelle Neurodegeneration der UMG unter der Leitung von MBExC Mitglied Prof. Dr. Tiago Outeiro und Dr. Anita Krisko gesammelt und zu einer Installation zusammengefügt. Diese Installation diente Malte Orth als Grundlage für eine Graffiti-Sprühaktion. Die öffentliche Live-Performance fand im
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24.04.2023

Generation of a genetically-modified induced pluripotent stem cell line harboring an oncogenic gene variant KRAS p.G12V

Authors Busley AV, Kleinsorge M, Cyganek L   Journal Stem Cell Research   Citation Stem Cell Res. 2023 Apr 24;69:103105.   Abstract Activating KRAS codon 12 gene variants are known to cause severe RAS-MAPK and PI3K-AKT signaling pathway hyperactivity and are frequently involved in the development of various carcinomas. Here,
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24.04.2023

Quantitative Magnetic Resonance Imaging by Nonlinear Inversion of the Bloch Equations

Authors Scholand N, Wang X, Roeloffs V, Rosenzweig S, Uecker M Journal Magnetic Resonance in Medicine Citation Magn Reson Med. 2023 Apr 24. Abstract Purpose: Development of a generic model-based reconstruction framework for multiparametric quantitative MRI that can be used with data from different pulse sequences. Methods: Generic nonlinear model-based
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20.04.2023

Influence of phosphorylation on intermediate filaments

Authors Kraxner J, Köster S Journal Biological Chemistry Citation Biol Chem. 2023 Apr 20. Abstract The cytoskeleton of eukaryotes consists of actin filaments, microtubules and intermediate filaments (IF). IFs, in particular, are prone to pronounced phosphorylation, leading to additional charges on the affected amino acids. In recent years, a variety
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