2023

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28.06.2023

Is it all the RAGE? Defining the role of the receptor for advanced glycation end products in Parkinson’s disease

Authors Gasparotto J, Somensi N, Girardi CS, Bittencourt RR, de Oliveira LM, Hoefel LP, Scheibel IM, Peixoto DO, Moreira JCF, Outeiro TF, Gelain DP Journal Journal of Neurochemistry Citation J Neurochem. 2023 Jun 28. Abstract The receptor for advanced glycation end products (RAGE) is a transmembrane receptor that belongs to
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28.06.2023

Targeting Biomolecular Condensation and Protein Aggregation against Cancer

Authors Silva JL, Foguel D, Ferreira VF, Vieira TCRG, Marques MA, Ferretti GDS, Outeiro TF, Cordeiro Y, de Oliveira GAP Journal Chemical Reviews Citation Chem Rev. 2023 Jun 28. Abstract Biomolecular condensates, membrane-less entities arising from liquid-liquid phase separation, hold dichotomous roles in health and disease. Alongside their physiological functions,
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26.06.2023

Structural insights into human co-transcriptional capping

Authors Garg G, Dienemann C, Farnung L, Schwarz J, Linden A, Urlaub H, Cramer P Journal Molecular Cell Citation Mol Cell. 2023 Jul 20;83(14):2464-2477.e5. Abstract Co-transcriptional capping of the nascent pre-mRNA 5′ end prevents degradation of RNA polymerase (Pol) II transcripts and suppresses the innate immune response. Here, we provide
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26.06.2023

Statistical analysis of random objects via metric measure Laplacians

Authors Mordant G, Munk A Journal SIAM Journal on Mathematics of Data Science Citation IAM Journal on Mathematics of Data Science 2023 5:2, 528-557 Abstract In this paper, we consider a certain convolutional Laplacian for metric measure spaces and investigate its potential for the statistical analysis of complex objects. The
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Patrick Cramer, der neue Präsident der Max-Planck-Gesellschaft. © Christoph Mukherjee

23.06.2023

Patrick Cramer übernimmt als Max-Planck-Präsident

Auf der Festversammlung der Max-Planck-Gesellschaft in Göttingen am 22. Juni 2023 übergab Martin Stratmann mit der Amtskette auch symbolisch die Aufgabe an seinen Nachfolger und MBExC Mitglied Patrick Cramer. Dieser würdigte die Verdienste Stratmanns und skizzierte in seiner Antrittsrede, welche drei großen Handlungsfelder er für eine zukunftsfähige Max-Planck-Gesellschaft sieht. Klicken
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21.06.2023

Molecular and cellular evidence for the impact of a hypertrophic cardiomyopathy-associated RAF1 variant on the structure and function of contractile machinery in bioartificial cardiac tissues

Authors Nakhaei-Rad S, Haghighi F, Bazgir F, Dahlmann J, Busley AV, Buchholzer M, Kleemann K, Schänzer A, Borchardt A, Hahn A, Kötter S, Schanze D, Anand R, Funk F, Kronenbitter AV, Scheller J, Piekorz RP, Reichert AS, Volleth M, Wolf MJ, Cirstea IC, Gelb BD, Tartaglia M, Schmitt JP, Krüger
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20.06.2023

Null and missense mutations of ERI1 cause a recessive phenotypic dichotomy in humans

Authors Guo L, Salian S, Xue JY, Rath N, Rousseau J, Kim H, Ehresmann S, Moosa S, Nakagawa N, Kuroda H, Clayton-Smith J, Wang J, Wang Z, Banka S, Jackson A, Zhang YM, Wei ZJ, Hüning I, Brunet T, Ohashi H, Thomas MF, Bupp C, Miyake N, Matsumoto N, Mendoza-Londono
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20.06.2023

Convergence of Empirical Optimal Transport in Unbounded Settings

Authors Staudt T, Hundrieser S Journal ArXiv Citation arXiv:2306.11499 Abstract In compact settings, the convergence rate of the empirical optimal transport cost to its population value is well understood for a wide class of spaces and cost functions. In unbounded settings, however, hitherto available results require strong assumptions on the
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16.06.2023

Physiology of intracellular calcium buffering

Authors Eisner D, Neher E, Taschenberger H, Smith G Journal Physiological Reviews Citation Physiol Rev. 2023 Jun 16. Abstract Calcium signalling underlies much of physiology. Almost all the Ca2+ in the cytoplasm is bound to buffers, with typically only about 1% being freely ionized at resting levels in most cells.
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16.06.2023

Diversity of Ganglion Cell Responses to Saccade-like Image Shifts in the Primate Retina

Authors Krüppel S, Khani MH, Karamanlis D, Erol YC, Zapp SJ, Mietsch M, Protti DA, Rozenblit F, Gollisch T Journal Journal of Neuroscience Citation J Neurosci. 2023 Jun 16:JN-RM-1561-22. Abstract Saccades are a fundamental part of natural vision. They interrupt fixations of the visual gaze and rapidly shift the image
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