2023

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19.07.2023

Evaluation of Novel Enhancer Compounds in Gentamicin-Mediated Readthrough of Nonsense Mutations in Rett Syndrome

Authors Wong KM, Wegener E, Baradaran-Heravi A, Huppke B, Gärtner J, Huppke P Journal International Journal of Molecular Sciences Citation Int J Mol Sci. 2023 Jul 19;24(14):11665. Abstract Rett syndrome (RTT), a severe X-linked neurodevelopmental disorder, is primarily caused by mutations in the methyl CpG binding protein 2 gene (MECP2).
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18.07.2023

Minimax detection of localized signals in statistical inverse problems

Authors Pohlmann M, Werner F, Munk A Journal Information and Inference: A Journal of the IMA Citation Information and Inference: A Journal of the IMA, Volume 12, Issue 3, September 2023, iaad026. Abstract We investigate minimax testing for detecting local signals or linear combinations of such signals when only indirect
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11.07.2023

HAV-Peptides Attached to Colloidal Probes Faithfully Detect E-Cadherins Displayed on Living Cells

Authors Toy S, Dietz J, Naumann P, Trothe J, Thomas F, Diederichsen U, Steinem C, Janshoff A Journal Chemistry Citation Chemistry. 2023 Jul 11;29(39):e202203904. Abstract Cell adhesion molecules are crucial for a variety of biological processes, including wound healing, barrier formation and tissue homeostasis. One of them is E-cadherin which
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11.07.2023

HAV-Peptides Attached to Colloidal Probes Faithfully Detect E-Cadherins Displayed on Living Cells

Authors Toy S, Dietz J, Naumann P, Trothe J, Thomas F, Diederichsen U, Steinem C, Janshoff A Journal Chemistry – A European Journal Citation Chemistry. 2023 Jul 11;29(39):e202203904 Abstract Cell adhesion molecules are crucial for a variety of biological processes, including wound healing, barrier formation and tissue homeostasis. One of
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10.07.2023

Effect of tissue fixation on the optical properties of structural components assessed by non-linear microscopy imaging

Authors Markus MA, Ferrari DP, Alves F, Ramos-Gomes F Journal Biomedical Optics Express Citation Biomed. Opt. Express 14, 3988-4002 (2023). Abstract Fixation methods such as formalin are commonly used for the preservation of tissue with the aim of keeping their structure as close as possible to the native condition. However,
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08.07.2023

More than meets the eye in Parkinson’s disease and other synucleinopathies: from proteinopathy to lipidopathy

Authors Flores-Leon M, Outeiro TF Journal Acta Neuropathologica Citation Acta Neuropathol. 2023 Jul 8. Abstract The accumulation of proteinaceous inclusions in the brain is a common feature among neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease (PD), and dementia with Lewy bodies (DLB). The main neuropathological hallmark of PD and
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07.07.2023

Vicious Twins: RyR2 Dysfunction and Structural Remodeling

Authors Voigt N, Seibertz F, Fakuade FE Journal Circulation Research Citation Circ Res. 2023 Jul 7;133(2):193-195. Abstract No abstract available. DOI 10.1161/CIRCRESAHA.123.323144   Pubmed Link  
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06.07.2023

Piccolino is required for ribbon architecture at cochlear inner hair cell synapses and for hearing

Authors Michanski S, Kapoor R, Steyer A, Möbius W, Früholz I, Ackermann F, Gültas M, Garner CC, Hamra FK, Neef J, Strenzke N, Moser T, Wichmann C Journal Embo Reports Citation EMBO Reports (2023)e56702. Abstract Cochlear inner hair cells (IHCs) form specialized ribbon synapses with spiral ganglion neurons that tirelessly
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06.07.2023

ARS2 instructs early transcription termination-coupled RNA decay by recruiting ZC3H4 to nascent transcripts

Authors Rouvière JO, Salerno-Kochan A, Lykke-Andersen S, Garland W, Dou Y, Rathore O, Smidova Molska E, Wu G, Schmid M, Bugai A, Jakobsen L, Zumer K, Cramer P, Andersen JS, Conti E, Jensen TH Journal Molecular Cell Citation Mol Cell. 2023 Jul 6;83(13):2240-2257.e6. Abstract The RNA-binding ARS2 protein is centrally
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Dr. Andrea Markus (MPI-NAT), Prof. Dr. Frauke Alves (UMG and MPI-NAT), and Priv.-Doz. Dr. Christian Dullin (UMG). Photo: umg/spförtner

05.07.2023

Echtzeit-Diagnostik für klinischen Einsatz mit verbesserter Fluoreszenzbildgebung

Göttinger Forscher*innen, unter der Leitung von MBExC Mitglied Prof. Dr. Frauke Alves (Universitätsmedizin Göttingen und MPI für Multidisziplinäre Naturwissenschaften) sind beteiligt an einem europäischen Projekt zur Entwicklung einer neuen Generation von Fluoreszenzbildgebung im nahen Infrarotbereich. Kombiniert mit spezifischen optischen Sonden soll das Verfahren für die Bildgebung bei medizinischen Eingriffen und
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