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Authors Gregor C, Grimm F, Rehman J, Wurm CA, Egner A Journal Cells Citation Cells 2024, 13(8), 683. Abstract STED nanoscopy allows for the direct observation of dynamic processes in living cells and tissues with diffraction-unlimited resolution. Although fluorescent proteins can be used for STED imaging, these labels are often

Authors Oliveira da Silva MI, Santejo M, Babcock IW, Magalhães A, Minamide LS, Won SJ, Castillo E, Gerhardt E, Fahlbusch C, Swanson RA, Outeiro TF, Taipa R, Ruff M, Bamburg JR, Liz MA Journal Cell Death & Disease Citation Cell Death Dis. 2024 Apr 13;15(4):264. Abstract Cognitive dysfunction and dementia

Authors Meissner-Bernard C, Jenkins B, Rupprecht P, Arn Bouldoires E, Zenke F, Friedrich RW, Frank T Journal BioRxiv Citation bioRxiv 2024.04.09.588702. Abstract Structured connectivity in the brain organizes information by constraining neuronal dynamics. Theoretical models predict that memories are represented by balanced assemblies of excitatory and inhibitory neurons, but the

Authors Podoliak E, Lamm GHU, Marin E, Schellbach AV, Fedotov DA, Stetsenko A, Asido M, Maliar N, Bourenkov G, Balandin T, Baeken C, Astashkin R, Schneider TR, Bateman A, Wachtveitl J, Schapiro I, Busskamp V, Guskov A, Gordeliy V, Alekseev A, Kovalev K Journal Nature Communications Citation Nat Commun. 2024

Authors Höbartner C, Bohnsack KE, Bohnsack MT Journal Annual Review of Biochemistry Citation Annu Rev Biochem. 2024 Apr 10. Abstract Methylation of RNA nucleotides represents an important layer of gene expression regulation, and perturbation of the RNA methylome is associated with pathophysiology. In cells, RNA methylations are installed by RNA

Authors Gligonov I, Enderlein J Journal BioRxiv Citation bioRxiv 2024.04.06.588390. Abstract Zernike polynomials are a sequence of orthogonal polynomials that play a crucial role in optics and in particular in modeling microscopy systems. First introduced by Frits Zernike in 1934, they are particularly useful in expressing wavefront aberrations and thus

Authors Huet A, Mager T, Goßler C, Moser T Journal Annual Review of Neurosciences Citation Annu Rev Neurosci. 2024 Apr 9. Abstract The cochlear implant (CI) is considered the most successful neuroprosthesis as it enables speech comprehension in the majority of the million otherwise deaf patients. In hearing by electrical

Authors Gallea JI, Nevskyi O, Kazmierczak Z, Chen T, Miernikiewicz P, Chizhik A, Dabrowska K, Bates M, Enderlein J Journal BioRxiv Citation bioRxiv 2024.04.04.588072. Abstract In the burgeoning field of super-resolution fluorescence microscopy, significant efforts are being dedicated to expanding its applications into the three-dimensional domain. Various methodologies have been

Authors Outeiro TF, Kalia LV, Bezard E, Ferrario J, Lin CH, Salama M, Standaert DG, Taiwo L, Takahashi R, Vila M, Mollenhauer B, Svenningsson P; MDS Journal Movement Disorders Citation Mov Disord. 2024 Apr 4. Abstract Basic Science is crucial for the advancement of clinical care for Movement Disorders. Here,

Authors Bhatta A, Kuhle B, Yu RD, Spanaus L, Ditter K, Bohnsack KE, Hillen H Journal BioRxiv Citation bioRxiv 2024.04.04.588063. Abstract Eukaryotic transfer RNA (tRNA) precursors undergo sequential processing steps to become mature tRNAs. In humans, ELAC2 carries out 3’-end processing of both nucleus-encoded (nu-tRNAs) and mitochondria-encoded tRNAs (mt-tRNAs). ELAC2