Research Alliance

Authors Zhang S, Aibara S, Vos SM, Agafonov DE, Lührmann R, Cramer P Journal Science Citation Science. 2021 Jan 15;371(6526):305-309. Abstract To initiate cotranscriptional splicing, RNA polymerase II (Pol II) recruits the U1 small nuclear ribonucleoprotein particle (U1 snRNP) to nascent precursor messenger RNA (pre-mRNA). Here, we report the cryo–electron

Authors So C, Cheng S, Schuh M Journal Trends in Cell Biology Citation Trends in Cell Biology, Jan 2021, online. Abstract Phase separation has emerged as a new key principle of intracellular organization. Phase-separated structures play diverse roles in various biological processes and pathogenesis of protein aggregation diseases. Recent work

Authors Cheret C, Ganzella M, Preobraschenski J, Jahn R, Ahnert-Hilger G Journal Cell Reports Citation Cell Rep. 2021 Jan 12;34(2):108623. Abstract Vesicular glutamate transporters (VGLUTs) fill synaptic vesicles with glutamate. VGLUTs were originally identified as sodium-dependent transporters of inorganic phosphate (Pi), but the physiological relevance of this activity remains unclear.

Authors Kokic G, Hillen HS, Tegunov D, Dienemann C, Seitz F, Schmitzova J, Farnung L, Siewert A, Höbartner C, Cramer P Journal Nature Communications Citation Nat Commun. 2021 Jan 12;12(1):279. Abstract Remdesivir is the only FDA-approved drug for the treatment of COVID-19 patients. The active form of remdesivir acts as

Authors Bonnin EA, Fornasiero EF, Lange F, Turck CW, Rizzoli SO Journal BMC Molecular and Cell Biology Citation BMC Mol and Cell Biol 22, 5 (2021). Abstract Background Most of the cells of the mammalian retina are terminally differentiated, and do not regenerate once fully developed. This implies that these

Authors Dominguez-Meijide A, Parrales V, Vasili E, González-Lizárraga F, König A, Lázaro DF, Lannuzel A, Haik S, Del Bel E, Chehín R, Raisman-Vozari R, Michel PP, Bizat N, Outeiro TF Journal Neurobiology of Disease Citation Neurobiol Dis. 2021 Jan 8;151:105256. Abstract Parkinson’s disease (PD) and dementia with Lewy bodies (DLB)

Authors Zimmermann WH Journal Circulation Research Citation Circ Res. 2021 Jan 8;128(1):39-41. Abstract No abstract available. DOI 10.1161/CIRCRESAHA.120.318494 Pubmed Link  

Authors Wrobel C, Zafeiriou MP, Moser T Journal EBioMedicine Citation EBioMedicine. 2021 Jan 7;63:103171. Abstract Sensorineural hearing impairment is the most frequent form of hearing impairment affecting 1–2 in 1000 newborns and another 1 in 1000 adolescents. More than 50% of congenital hearing impairment is of genetic origin and some

Authors Outeiro TF Journal Molecular Neurobiology Citation Mol Neurobiol. 2021 Jan 7. Abstract In protein aggregation disorders, we assume that, during the process of protein aggregation, different types of aggregated species (oligomers, protofibrils, fibrils, etc.) are formed, some of which can be toxic to cells/tissues/organs. Recent evidence from numerous studies

Authors Rankovic V, Vogl C, Dörje N M, Bahader I, Duque-Afonso C J, Thirumalai A, Weber T, Kusch K, Strenzke N, Moser T Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci. 13:600051. Abstract Hearing impairment is the most common sensory disorder in humans. So far, rehabilitation of profoundly deaf