Research Alliance

Authors Sakata E, Eisele MR, Baumeister W Journal Biochimica et Biophysica Acta – Proteins and Proteomics Citation Biochim Biophys Acta Proteins Proteom. 2021 Mar;1869(3):140583. Epub 2020 Dec 13. Abstract In eukaryotic cells, the ubiquitin-proteasome system serves to remove proteins that are either dysfunctional or no longer needed. The 26S proteasome

Authors Outeiro TF Journal Acta Neuropathologica (Editorial) Citation Acta Neuropathol. 2021 Feb 24. Abstract No abstract available DOI 10.1007/s00401-021-02290-7 Pubmed Link  

Authors Yousefi R, Fornasiero EF, Cyganek L, Montoya J, Jakobs S, Rizzoli SO, Rehling P, Pacheu-Grau D Journal EMBO Reports Citation EMBO Rep. 2021 Feb 15:e51635. Abstract Mitochondria possess a small genome that codes for core subunits of the oxidative phosphorylation system and whose expression is essential for energy production.

Authors Brás IC, Outeiro TF Journal Cells Citation Cells 2021, 10(2), 375. Abstract The accumulation of misfolded alpha-synuclein (aSyn) throughout the brain, as Lewy pathology, is a phenomenon central to Parkinson’s disease (PD) pathogenesis. The stereotypical distribution and evolution of the pathology during disease is often attributed to the cell-to-cell

Authors Möbius W, Hümmert S, Ruhwedel T, Kuzirian A, Gould R Journal Life Citation Life. 2021; 11(2):136. Abstract Although myelinated nervous systems are shared among 60,000 jawed vertebrates, studies aimed at understanding myelination have focused more and more on mice and zebrafish. To obtain a broader understanding of the myelination

Authors Silbern I, Pan KT, Fiosins M, Bonn S, Rizzoli SO, Fornasiero EF, Urlaub H, Jahn R Journal Molecular & Cellular Proteomics Citation Mol Cell Proteomics. 2021 Feb 11:100061. Abstract Synaptic transmission is mediated by the regulated exocytosis of synaptic vesicles. When the presynaptic membrane is depolarized by an incoming

Authors Epple R, Krüger D, Berulava T, Brehm G, Ninov M, Islam R, Köster S, Fischer A Journal Molecular Neurobiology Citation Mol Neurobiol. 2021 Feb 10. Abstract Neurons are highly compartmentalized cells that depend on local protein synthesis. Messenger RNAs (mRNAs) have thus been detected in neuronal dendrites, and more

Authors Sertel SM, von Elling-Tammen MS, Rizzoli SO Journal Journal of Neuroscience Citation J Neurosci. 2021 Feb 10;41(6):1157-1173. Abstract The activity and the metabolism of the brain change rhythmically during the day/night cycle. Such rhythmicity is also observed in cultured neurons from the suprachiasmatic nucleus, which is a critical center

Authors Sawicka A, Villamil G, Lidschreiber M, Darzacq X, Dugast-Darzacq C, Schwalb B, Cramer P Journal EMBO Journal Citation EMBO J. 2021 Feb 8:e107015. Abstract Eukaryotic RNA polymerase II (Pol II) contains a tail-like, intrinsically disordered carboxy-terminal domain (CTD) comprised of heptad-repeats, that functions in coordination of the transcription cycle

Authors Ulmke PA, Xie Y, Sokpor G, Pham L, Shomroni O, Berulava T, Rosenbusch J, Basu U, Fischer A, Nguyen HP, Staiger JF, Tuoc T Journal Development Citation Development. 2021 Feb 8;148(3):dev188276. Abstract Fine-tuned gene expression is crucial for neurodevelopment. The gene expression program is tightly controlled at different levels,