Science Advances

Home >> Publications >> Journal >> Science Advances
Feature image not available
05.11.2025

Charting the nanotopography of inner hair cell synapses using MINFLUX nanoscopy

Authors Kapoor R, Kim H, Garlick E, Lima MADRBF, Esch K, Ruhwedel T, Möbius W, Wolf F, Moser T Journal Science Advances Citation Sci. Adv.11,eady4344(2025). Abstract The cochlea encodes sounds into neural signals at the synapses of inner hair cells (IHCs) and spiral ganglion neurons (SGNs) with remarkable fidelity. To
Learn More
Feature image not available
17.10.2025

Structure and function of otoferlin, a synaptic protein of sensory hair cells essential for hearing

Authors Chen H, Cretu C, Trebilcock A, Evdokimova N, Babai N, Feldmann L, Leidner F, Benseler F, Mutschall S, Esch K, Szabo CZK, Pena V, Pape C, Grubmüller H, Strenzke N, Brose N, Wichmann C, Preobraschenski J, Moser T Journal Sciende Advances Citation Sci Adv. 2025 Oct 17;11(42):eady8532. Abstract Hearing
Learn More
Feature image not available
11.07.2025

Autonomous bioluminescence emission from transgenic mice

Authors Kiszka KA, Dullin C, Steffens H, Koenen T, Rothermel E, Alves F, Gregor C Journal Science Advances Citation Sci Adv. 2025 Jul 11;11(28):eads0463. Abstract The bacterial bioluminescence system can be applied to produce autonomous bioluminescence in mammalian cells. Until now, the system has only been stably inserted into cells
Learn More
Feature image not available
04.07.2025

CryoRhodopsins: A comprehensive characterization of a group of microbial rhodopsins from cold environments

Authors Lamm GHU, Marin E, Alekseev A, Schellbach AV, Stetsenko A, Haro-Moreno JM, Bourenkov G, Borshchevskiy V, Asido M, Agthe M, Engilberge S, Rose SL, Caramello N, Royant A, Schneider TR, Bateman A, Mager T, Moser T, Rodriguez-Valera F, Wachtveitl J, Guskov A, Kovalev K Journal Science Advances Citation Sci
Learn More
Feature image not available
18.06.2025

Gating of hair cell Ca2+ channels governs the activity of cochlear neurons

Authors Karagulyan N, Thirumalai A, Michanski S, Qi Y, Fang Q, Wang H, Ortner NJ, Striessnig J, Strenzke N, Wichmann C, Hua Y, Moser T Journal Science Advances Citation Sci Adv. 2025 Jun 20;11(25):eadu7898. Abstract Our sense of hearing processes sound intensities spanning six orders of magnitude. In the ear,
Learn More
Feature image not available
23.04.2025

Synaptophysin accelerates synaptic vesicle fusion by expanding the membrane upon neurotransmitter loading

Authors Preobraschenski J, Kreutzberger AJB, Ganzella M, Münster-Wandowski A, Kreutzberger MAB, Oolsthorn LHM, Seibert S, Kiessling V, Riedel D, Witkowska A, Ahnert-Hilger G, Tamm LK, Jahn R Journal Science Advances Citation Sci Adv. 2025 Apr 25;11(17):eads4661. Abstract Synaptic transmission is mediated by the exocytotic release of neurotransmitters stored in synaptic
Learn More
Feature image not available
18.04.2025

Proteorhodopsin insights into the molecular mechanism of vectorial proton transport

Authors Bukhdruker S, Gushchin I, Shevchenko V, Kovalev K, Polovinkin V, Tsybrov F, Astashkin R, Alekseev A, Mikhaylov A, Bukhalovich S, Bratanov D, Ryzhykau Y, Kuklina D, Caramello N, Rokitskaya T, Antonenko Y, Rulev M, Stoev C, Zabelskii D, Round E, Rogachev A, Borshchevskiy V, Ghai R, Bourenkov G, Zeghouf
Learn More
Feature image not available
11.04.2025

Distinct transmission sites within a synapse for strengthening and homeostasis

Authors Yang Y, Wong MH, Huang X, Chiu DN, Liu YZ, Prabakaran V, Imran A, Panzeri E, Chen Y, Huguet P, Kunisky A, Ho J, Dong Y, Carter BC, Xu W, Schlüter OM Journal Science Advances Citation Sci Adv. 2025 Apr 11;11(15):eads5750. Abstract At synapses, miniature synaptic transmission forms the
Learn More
Feature image not available
07.06.2024

Mechanism of human PINK1 activation at the TOM complex in a reconstituted system

Authors Raimi OG, Ojha H, Ehses K, Dederer V, Lange SM, Rivera CP, Deegan TD, Chen Y, Wightman M, Toth R, Labib KPM, Mathea S, Ranson N, Fernández-Busnadiego R, Muqit MMK Journal Science Advances Citation Sci Adv. 2024 Jun 7;10(23):eadn7191. Abstract Loss-of-function mutations in PTEN-induced kinase 1 (PINK1) are a
Learn More
Feature image not available
25.08.2023

Modular architecture facilitates noise-driven control of synchrony in neuronal networks

Authors Yamamoto H, Spitzner FP, Takemuro T, Buendía V, Murota H, Morante C, Konno T, Sato S, Hirano-Iwata A, Levina A, Priesemann V, Muñoz MA, Zierenberg J, Soriano J Journal Science Advances Citation Sci Adv. 2023 Aug 25;9(34):eade1755. Abstract High-level information processing in the mammalian cortex requires both segregated processing
Learn More
X
EN DE
X
X