Science Advances

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10.06.2022

Isotropic Three-Dimensional Dual-Color Super-Resolution Microscopy with Metal-Induced Energy Transfer

Authors Thiele JC, Jungblut M, Helmerich DA, Tsukanov R, Chizhik A, Chizhik AI, Schnermann MJ, Sauer M, Nevskyi O, Enderlein J Journal Science Advances Citation Sci Adv. 2022 Jun 10;8(23):eabo2506. Abstract Over the past two decades, super-resolution microscopy has seen a tremendous development in speed and resolution, but for most
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02.06.2022

Resolving the molecular architecture of the photoreceptor active zone by 3D-MINFLUX

Authors Grabner CP, Jansen I, Neef J, Weihs T, Schmidt R, Riedel D, Wurm CA, Moser T Journal Science Advances Citation Sci Adv. 2022 Jul 15;8(28):eabl7560. Abstract Cells assemble macromolecular complexes into scaffoldings that serve as substrates for catalytic processes. Years of molecular neurobiology indicate that neurotransmission depends on such
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15.04.2022

Cln5 represents a new type of cysteine-based S-depalmitoylase linked to neurodegeneration

Authors Luebben AV, Bender D, Becker S, Crowther LM, Erven I, Hofmann K, Söding J, Klemp H, Bellotti C, Stäuble A, Qiu T, Kathayat RS, Dickinson BC, Gärtner J, Sheldrick GM, Krätzner R, Steinfeld R Journal Science Advances Citation Sci Adv. 2022 Apr 15;8(15):eabj8633. Abstract Genetic CLN5 variants are associated
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17.09.2021

H3 acetylation selectively promotes basal progenitor proliferation and neocortex expansion

Authors Kerimoglu C, Pham L, Tonchev AB, Sakib MS, Xie Y, Sokpor G, Ulmke PA, Kaurani L, Abbas E, Nguyen H, Rosenbusch J, Michurina A, Capece V, Angelova M, Maricic N, Brand-Saberi B, Esgleas M, Albert M, Minkov R, Kovachev E, Teichmann U, Seong RH, Huttner WB, Nguyen HP, Stoykova
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09.06.2021

Stable but not rigid: Chronic in vivo STED nanoscopy reveals extensive remodeling of spines, indicating multiple drivers of plasticity

Authors Steffens H, Mott AC, Li S, Wegner W, Švehla P, Kan VWY, Wolf F, Liebscher S, Willig KI Journal Science Advances Citation Sci. Adv. 2021; 7 : eabf2806. Abstract Excitatory synapses on dendritic spines of pyramidal neurons are considered a central memory locus. To foster both continuous adaption and
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14.05.2021

Insights into the molecular mechanism of amyloid filament formation: Segmental folding of α-synuclein on lipid membranes

Authors Antonschmidt L, Dervişoğlu R, Sant V, Movellan KT, Mey I, Riedel D, Steinem C, Becker S, Andreas LB, Griesinger C Journal Science Advances Citation Sci Adv. 2021 May 14;7(20):eabg2174. Abstract Recent advances in the structural biology of disease-relevant α-synuclein fibrils have revealed a variety of structures, yet little is
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05.03.2021

Trans-synaptic assemblies link synaptic vesicles and neuroreceptors

Authors Martinez-Sanchez A, Laugks U, Kochovski Z, Papantoniou C, Zinzula L, Baumeister W, Lučić V Journal Science Advances Citation Sci Adv. 2021 Mar 5;7(10):eabe6204. Abstract   Synaptic transmission is characterized by fast, tightly coupled processes and complex signaling pathways that require a precise protein organization, such as the previously reported
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14.08.2020

Conformational dynamics of a G protein-coupled receptor helix 8 in lipid membranes

Authors Dijkman PM, Muñoz-García JC, Lavington SR, Kumagai PS, Dos Reis RI, Yin D, Stansfeld PJ, Costa-Filho AJ, Watts A Journal Science Advances Citation Sci Adv. 2020 Aug 14;6(33):eaav8207. Abstract G protein-coupled receptors (GPCRs) are the largest and pharmaceutically most important class of membrane proteins encoded in the human genome,
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08.12.2019

The long noncoding RNA neuroLNC regulates presynaptic activity by interacting with the neurodegeneration-associated protein TDP-43

Authors Keihani S, Kluever V, Mandad S, Bansal V, Rahman R, Fritsch E, Gomes LC, Gartner A, Kugler S, Urlaub H, Wren JD, Bonn S, Rizzoli SO, Fornasiero EF Journal Science Advances Citation Sci Adv. 2019 Dec 18;5(12):eaay2670. Abstract The cellular and the molecular mechanisms by which long noncoding RNAs
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