Nature Structural & Molecular Biology

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08.02.2024

Structural mechanisms of autoinhibition and substrate recognition by the ubiquitin ligase HACE1

Authors Düring J, Wolter M, Toplak JJ, Torres C, Dybkov O, Fokkens TJ, Bohnsack KE, Urlaub H, Steinchen W, Dienemann C, Lorenz S   Journal Nature Structural & Molecular Biology   Citation Nat Struct Mol Biol (2024).   Abstract Ubiquitin ligases (E3s) are pivotal specificity determinants in the ubiquitin system
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06.11.2023

Structure of the transcribing RNA polymerase II-Elongin complex

Authors Chen Y, Kokic G, Dienemann C, Dybkov O, Urlaub H, Cramer P Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol. 2023 Nov 6. Abstract Elongin is a heterotrimeric elongation factor for RNA polymerase (Pol) II transcription that is conserved among metazoa. Here, we report three cryo-EM
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07.08.2023

Structural conservation of antibiotic interaction with ribosomes

Authors Paternoga H, Crowe-McAuliffe C, Bock LV, Koller TO, Morici M, Beckert B, Myasnikov AG, Grubmüller H, Nováček J, Wilson DN Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol (2023). Abstract The ribosome is a major target for clinically used antibiotics, but multidrug resistant pathogenic bacteria are
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29.06.2023

Mechanisms of inward transmembrane proton translocation

Authors Kovalev K, Tsybrov F, Alekseev A, Shevchenko V, Soloviov D, Siletsky S, Bourenkov G, Agthe M, Nikolova M, von Stetten D, Astashkin R, Bukhdruker S, Chizhov I, Royant A, Kuzmin A, Gushchin I, Rosselli R, Rodriguez-Valera F, Ilyinskiy N, Rogachev A, Borshchevskiy V, Schneider TR, Bamberg E, Gordeliy V
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27.03.2023

Discrimination between cyclic-nucleotides by cyclic-nucleotide gated ion channels

Authors Pan Y, Pohjolainen E, Schmidpeter PAM, Vaiana AC, Nimigean CM, Grubmüller H, Scheuring S   Journal Nature Structural and Molecular Biology   Citation Nat Struct Mol Biol. 2023 Mar 27.   Abstract Cyclic nucleotide-gated ion channels are crucial in many physiological processes such as vision and pacemaking in the
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24.11.2022

Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II

Authors Rengachari S, Schilbach S, Kaliyappan T, Gouge J, Zumer K, Schwarz J, Urlaub H, Dienemann C, Vannini A, Cramer P Journal Nature Structural and Molecular Biology Citation Nat Struct Mol Biol. 2022 Nov 24. Abstract RNA polymerase II (Pol II) carries out transcription of both protein-coding and non-coding genes.
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21.11.2022

Structures of transcription preinitiation complex engaged with the +1 nucleosome

Authors Wang H, Schilbach S, Ninov M, Urlaub H, Cramer P Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol. 2022 Nov 21. Abstract The preinitiation complex (PIC) assembles on promoters of protein-coding genes to position RNA polymerase II (Pol II) for transcription initiation. Previous structural studies revealed
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17.05.2022

Histone H1 binding to nucleosome arrays depends on linker DNA length and trajectory

Authors Dombrowski M, Engeholm M, Dienemann C, Dodonova, S. Cramer P Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol 29, 493–501 (2022). Abstract Throughout the genome, nucleosomes often form regular arrays that differ in nucleosome repeat length (NRL), occupancy of linker histone H1 and transcriptional activity. Here,
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06.09.2021

Structural basis of RNA processing by human mitochondrial RNase P

Authors Bhatta A, Dienemann C, Cramer P, Hillen HS Journal Nature Structural and Molecular Biology Citation Nat Struct Mol Biol (2021). Abstract Human mitochondrial transcripts contain messenger and ribosomal RNAs flanked by transfer RNAs (tRNAs), which are excised by mitochondrial RNase (mtRNase) P and Z to liberate all RNA species.
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11.08.2021

Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis

Authors Kabinger F, Stiller C, Schmitzová J, Dienemann C, Kokic G, Hillen HS, Höbartner C, Cramer P Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol (2021). 2021 Aug 11. Abstract Molnupiravir is an orally available antiviral drug candidate currently in phase III trials for the treatment of
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