Nature

Authors Wolfram-Schauerte M, Pozhydaieva N, Grawenhoff J, Welp LM, Silbern I, Wulf A, Billau FA, Glatter T, Urlaub H, Jäschke A, Höfer K Journal Nature Citation Nature. 2023 Aug 16. Abstract The mechanisms by which viruses hijack the genetic machinery of the cells they infect are of current interest. When

Authors Schmitzová J, Cretu C, Dienemann C, Urlaub H, Pena V Journal Nature Citation Nature. 2023 May 10. Abstract Pre-mRNA splicing follows a pathway driven by ATP-dependent RNA helicases. A crucial event of the splicing pathway is the catalytic activation, which takes place at the transition between the activated Bact

Authors Kosmidis E, Shuttle CG, Preobraschenski J, Ganzella M, Johnson PJ, Veshaguri S, Holmkvist J, Møller MP, Marantos O, Marcoline F, Grabe M, Pedersen JL, Jahn R, Stamou D Journal Nature Citation Nature. 2022 Nov;611(7937):827-834. Abstract Vacuolar-type adenosine triphosphatases (V-ATPases)1,2,3 are electrogenic rotary mechanoenzymes structurally related to F-type ATP synthases4,5.

Authors Kokic G, Wagner FR, Chernev A, Urlaub H, Cramer P Journal Nature Citation Nature 2021 Abstract Transcription-coupled DNA repair removes bulky DNA lesions from the genome and protects cells against ultraviolet (UV) irradiation. Transcription-coupled DNA repair begins when RNA polymerase II (Pol II) stalls at a DNA lesion and recruits

Authors Aibara S, Schilbach S, Cramer P Journal Nature Citation Nature. 2021 Apr 26. Abstract The initiation of transcription is a focal point for the regulation of gene activity during mammalian cell differentiation and development. To initiate transcription, RNA polymerase II (Pol II) assembles with general transcription factors into a

Authors Bonekamp NA, Peter B, Hillen HS, Felser A, Bergbrede T, Choidas A, Horn M, Unger A, Di Lucrezia R, Atanassov I, Li X, Koch U, Menninger S, Boros J, Habenberger P, Giavalisco P, Cramer P, Denzel MS, Nussbaumer P, Klebl B, Falkenberg M, Gustafsson CM, Larsson NG Journal Nature

Authors Hillen HS, Kokic G, Farnung L, Dienemann C, Tegunov D, Cramer P Journal Nature Citation Nature 584, 154–156 (2020). Abstract The new coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses an RNA-dependent RNA polymerase (RdRp) for the replication of its genome and the transcription of its genes1-3. Here

Authors Dodonova SO, Zhu F, Dienemann C, Taipale J, Cramer P Journal Nature Citation Nature 580, 669–672 (2020). Abstract ‘Pioneer’ transcription factors are required for stem-cell pluripotency, cell differentiation and cell reprogramming1,2. Pioneer factors can bind nucleosomal DNA to enable gene expression from regions of the genome with closed chromatin.

Authors Wagner FR, Dienemann C, Wang H, Stützer A, Tegunov D, Urlaub H, Cramer P Journal Nature Citation Nature 579, 448–451 (2020). Abstract Chromatin-remodelling complexes of the SWI/SNF family function in the formation of nucleosome-depleted, transcriptionally active promoter regions (NDRs). In the yeast Saccharomyces cerevisiae, the essential SWI/SNF complex RSC

Authors Yasuda S, Tsuchiya H, Kaiho A, Guo Q, Ikeuchi K, Endo A, Arai N, Ohtake F, Murata S, Inada T, Baumeister W, Fernandez-Busnadiego R, Tanaka K, Saeki Y Journal Nature Citation Nature. 2020 Feb;578(7794):296-300. Abstract The proteasome is a major proteolytic machine that regulates cellular proteostasis through selective degradation