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23.11.2022

Regulation of the mammalian-brain V-ATPase through ultraslow mode-switching

Authors Kosmidis E, Shuttle CG, Preobraschenski J, Ganzella M, Johnson PJ, Veshaguri S, Holmkvist J, Møller MP, Marantos O, Marcoline F, Grabe M, Pedersen JL, Jahn R, Stamou D Journal Nature Citation Nature. 2022 Nov;611(7937):827-834. Abstract Vacuolar-type adenosine triphosphatases (V-ATPases)1,2,3 are electrogenic rotary mechanoenzymes structurally related to F-type ATP synthases4,5.
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15.09.2021

Structural basis of human transcription–DNA repair coupling

Authors Kokic G, Wagner FR, Chernev A, Urlaub H, Cramer P Journal Nature Citation Nature 2021 Abstract Transcription-coupled DNA repair removes bulky DNA lesions from the genome and protects cells against ultraviolet (UV) irradiation. Transcription-coupled DNA repair begins when RNA polymerase II (Pol II) stalls at a DNA lesion and recruits
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01.04.2021

Structures of mammalian RNA polymerase II pre-initiation complexes

Authors Aibara S, Schilbach S, Cramer P Journal Nature Citation Nature. 2021 Apr 26. Abstract The initiation of transcription is a focal point for the regulation of gene activity during mammalian cell differentiation and development. To initiate transcription, RNA polymerase II (Pol II) assembles with general transcription factors into a
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16.12.2020

Small-molecule inhibitors of human mitochondrial DNA transcription

Authors Bonekamp NA, Peter B, Hillen HS, Felser A, Bergbrede T, Choidas A, Horn M, Unger A, Di Lucrezia R, Atanassov I, Li X, Koch U, Menninger S, Boros J, Habenberger P, Giavalisco P, Cramer P, Denzel MS, Nussbaumer P, Klebl B, Falkenberg M, Gustafsson CM, Larsson NG Journal Nature
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21.05.2020

Structure of replicating SARS-CoV-2 polymerase

Authors Hillen HS, Kokic G, Farnung L, Dienemann C, Tegunov D, Cramer P Journal Nature Citation Nature 584, 154–156 (2020). Abstract The new coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses an RNA-dependent RNA polymerase (RdRp) for the replication of its genome and the transcription of its genes1-3. Here
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22.04.2020

Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function

Authors Dodonova SO, Zhu F, Dienemann C, Taipale J, Cramer P Journal Nature Citation Nature 580, 669–672 (2020). Abstract ‘Pioneer’ transcription factors are required for stem-cell pluripotency, cell differentiation and cell reprogramming1,2. Pioneer factors can bind nucleosomal DNA to enable gene expression from regions of the genome with closed chromatin.
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11.03.2020

Structure of SWI/SNF chromatin remodeller RSC bound to a nucleosome

Authors Wagner FR, Dienemann C, Wang H, Stützer A, Tegunov D, Urlaub H, Cramer P Journal Nature Citation Nature 579, 448–451 (2020). Abstract Chromatin-remodelling complexes of the SWI/SNF family function in the formation of nucleosome-depleted, transcriptionally active promoter regions (NDRs). In the yeast Saccharomyces cerevisiae, the essential SWI/SNF complex RSC
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07.02.2020

Stress- And Ubiquitylation-Dependent Phase Separation Of The Proteasome

Authors Yasuda S, Tsuchiya H, Kaiho A, Guo Q, Ikeuchi K, Endo A, Arai N, Ohtake F, Murata S, Inada T, Baumeister W, Fernandez-Busnadiego R, Tanaka K, Saeki Y Journal Nature Citation Nature. 2020 Feb;578(7794):296-300. Abstract The proteasome is a major proteolytic machine that regulates cellular proteostasis through selective degradation
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01.01.2020

Structure of the transcription coactivator SAGA

Authors Wang H, Dienemann C, Stutzer A, Urlaub H, Cheung ACM, Cramer P Journal Nature Citation Nature. 2020 Jan;577(7792):717-720. Abstract Gene transcription by RNA polymerase II is regulated by activator proteins that recruit the coactivator complexes SAGA (Spt-Ada-Gcn5-acetyltransferase)(1,2) and transcription factor IID (TFIID)(2-4). SAGA is required for all regulated transcription(5)
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28.08.2019

Organization and regulation of gene transcription

Authors Cramer P Journal Nature Citation Nature. 2019 Sep;573(7772):45-54. Abstract The regulated transcription of genes determines cell identity and function. Recent structural studies have elucidated mechanisms that govern the regulation of transcription by RNA polymerases during the initiation and elongation phases. Microscopy studies have revealed that transcription involves the condensation
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